International Journal of Radiation Oncology * Biology * Physics
Volume 71, Issue 2 , Pages 371-376 , 1 June 2008

Does Adjuvant Radiation Therapy Improve Outcomes In pT1-3N0 Oral Cavity Cancer With Tumor-Free Margins and Perineural Invasion?

  • Chun-Ta Liao, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Joseph Tung-Chieh Chang, M.D., M.H.A.

      Affiliations

    • Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Hung-Ming Wang, M.D.

      Affiliations

    • Department of Medical Oncology, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Shu-Hang Ng, M.D.

      Affiliations

    • Department of Diagnostic Radiology, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Chuen Hsueh, M.D.

      Affiliations

    • Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Li-Yu Lee, M.D.

      Affiliations

    • Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Chih-Hung Lin, M.D.

      Affiliations

    • Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • I.-How Chen, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Shiang-Fu Huang, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Ann-Joy Cheng, Ph.D.

      Affiliations

    • Department of Medical Biotechnology, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Lai-Chu See, Ph.D.

      Affiliations

    • Department of Biostatistics Consulting Center/Department of Public Health, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • ,
  • Tzu-Chen Yen, M.D., Ph.D.

      Affiliations

    • Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Chang Gung University, Taoyuan, Taiwan
    • Corresponding Author InformationReprint requests to: Tzu-Chen Yen, MD, Ph.D., Department of Nuclear Medicine, Chang Gung Memorial Hospital at Taipei, 199, Tung Hwa North Road, Taipei 105, Taiwan, R.O.C. Tel: (+886) 3328-1200, ext. 2673; Fax: (+886) 3211-0052

Received 21 June 2007 ,Revised 30 August 2007 ,Accepted 9 October 2007.

References 

  1. Garzino-Demo P, Dell'Acqua A, Dalmasso P, et al. Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma. J Craniomaxillofac Surg. 2006;34:344–350
  2. Brandwein-Gensler M, Teixeira MS, Lewis CM, et al. Oral squamous cell carcinoma: Histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29:167–178
  3. Hinerman RW, Mendenhall WM, Morris CG, et al. Postoperative irradiation for squamous cell carcinoma of the oral cavity: 35-Year experience. Head Neck. 2004;26:984–994
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  16. Parsons JT, Mendenhall WM, Stringer SP, et al. An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity. Int J Radiat Oncol Biol Phys. 1997;39:137–148
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 Conflict of interest: none.

PII: S0360-3016(07)04429-X

doi: 10.1016/j.ijrobp.2007.10.015

International Journal of Radiation Oncology * Biology * Physics
Volume 71, Issue 2 , Pages 371-376 , 1 June 2008

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