International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 3 , Pages 685-692 , 1 March 2008

Outcomes of Risk-Adapted Fractionated Stereotactic Radiotherapy for Stage I Non–Small-Cell Lung Cancer

  • Frank J. Lagerwaard, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests to: Frank J. Lagerwaard, M.D., Ph.D., Department of Radiation Oncology, VU University Medical Center, de Boelelaan 1117, 1006 HV Amsterdam, The Netherlands. Tel: (+31) 20-4440414; Fax: (+31) 20-4440410
    • ,
  • Cornelis J.A. Haasbeek, M.D.

      Affiliations

    • Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Egbert F. Smit, M.D., Ph.D.

      Affiliations

    • Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Ben J. Slotman, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • S. Senan, M.R.C.P., F.R.C.R., Ph.D.

      Affiliations

    • Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands

Received 15 September 2007 ,Accepted 31 October 2007.

References 

  1. Mountain CF, Dresler CM. Regional lymph node classification for lung cancer staging. Chest. 1997;111:1718–1723
  2. Nesbitt JC, Putnam JB, Walsh GL, et al. Survival in early-stage non-small cell lung cancer. Ann Thorac Surg. 1995;60:466–472
  3. Damhuis R, Coonar A, Plaisier P, et al. A case-mix model for monitoring of postoperative mortality after surgery for lung cancer. Lung Cancer. 2006;51:123–129
  4. Little AG, Rusch VW, Bonner JA, et al. Patterns of surgical care of lung cancer patients. Ann Thorac Surg. 2005;80:2051–2056
  5. Allen MS, Darling GE, Pechet TT, et al. ACOSOG Z0030 Study Group Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial. Ann Thorac Surg. 2006;81:1013–1019
  6. Daniels JM, Eerenberg JP, Rijna H, et al. Mitotic index does not predict prognosis in stage IA non-small cell lung cancer. Lung Cancer. 2002;38:163–167
  7. Alexiou C, Beggs D, Onyeaka P, et al. Pneumonectomy for stage I (T1N0 and T2N0) nonsmall cell lung cancer has potent, adverse impact on survival. Ann Thorac Surg. 2003;76:1023–1028
  8. Wisnivesky JP, Bonomi M, Henschke C, et al. Radiation therapy for the treatment of unresected stage I-II non-small cell lung cancer. Chest. 2005;128:1461–1467
  9. Raz DJ, Zell JA, Ignatius Ou SH, et al. Natural history of stage I non-small cell lung cancer: Implications for early detection. Chest. 2007;132:193–199
  10. Uematsu M, Shioda A, Tahara K, et al. Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients: A preliminary experience. Cancer. 1998;82:1062–1070
  11. Wulf J, Hadinger U, Oppitz U, et al. Stereotactic radiotherapy of targets in the lung and liver. Strahlenther Onkol. 2001;177:645–655
  12. Hof H, Herfarth KK, Munter M, et al. Stereotactic single-dose radiotherapy of stage I non-small-cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 2003;56:335–341
  13. Timmerman R, Papiez L, McGarry R, et al. Extracranial stereotactic radioablation: Results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest. 2003;124:1946–1955
  14. Nyman J, Johansson KA, Hulten U. Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer-mature results for medically inoperable patients. Lung Cancer. 2006;51:97–103
  15. Onishi H, Shirato H, Nagata Y, et al. Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study. J Thorac Oncol. 2007;2(Suppl 3):S94–S100
  16. Lagerwaard FJ, Senan S, van Meerbeeck JP, et al. Has 3-D conformal radiotherapy (3D CRT) improved the local tumour control for stage I non-small cell lung cancer?. Radiother Oncol. 2002;63:151–157
  17. Underberg RW, Lagerwaard FJ, Cuijpers JP, et al. Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer. Int J Radiat Oncol Biol Phys. 2004;60:1283–1290
  18. Miller KL, Shafman TD, Anscher MS, et al. Bronchial stenosis: An underreported complication of high-dose external beam radiotherapy for lung cancer?. Int J Radiat Oncol Biol Phys. 2005;61:64–69
  19. Li F, Sone S, Abe H, et al. Malignant versus benign nodules at CT screening for lung cancer: Comparison of thin-section CT findings. Radiology. 2004;233:793–798
  20. Swensen SJ, Silverstein MD, Edell ES, et al. Solitary pulmonary nodules: Clinical prediction model versus physicians. Mayo Clin Proc. 1999;74:319–329
  21. Herder GJ, van Tinteren H, Golding RP, et al. Clinical prediction model to characterize pulmonary nodules: Validation and added value of 18F-fluorodeoxyglucose positron emission tomography. Chest. 2005;128:2490–2496
  22. van der Geld YG, Lagerwaard FJ, van Sornsen de Koste JR, et al. Reproducibility of target volumes generated using uncoached 4-dimensional CT scans for peripheral lung cancer. Radiat Oncol. 2006;1:43
  23. Haasbeek CJ, Lagerwaard FJ, Cuijpers JP, et al. Is adaptive treatment planning required for stereotactic radiotherapy of stage I non-small-cell lung cancer?. Int J Radiat Oncol Biol Phys. 2007;67:1370–1374
  24. Calhoun P, Feldman PS, Armstrong P, et al. The clinical outcome of needle aspirations of the lung when cancer is not diagnosed. Ann Thorac Surg. 1986;41:592–596
  25. Sawabata N, Ohta M, Matsumura A, et al. Thoracic Surgery Study Group of Osaka University Optimal distance of malignant negative margin in excision of nonsmall cell lung cancer: a multicenter prospective study. Ann Thorac Surg. 2004;77:415–420
  26. Sawada S, Yamashita M, Komori E, et al. Evaluation of resected tumors that were not diagnosed histologically but were suspected of lung cancer preoperatively. J Thorac Oncol. 2007;2(Suppl 4):S422
  27. Crestanello JA, Allen MS, Jett JR, et al. Thoracic surgical operations in patients enrolled in a computed tomographic screening trial. J Thorac Cardiovasc Surg. 2004;128:254–259
  28. Meyers BF, Haddad F, Siegel BA, et al. Cost-effectiveness of routine mediastinoscopy in computed tomography- and positron emission tomography-screened patients with stage I lung cancer. J Thorac Cardiovasc Surg. 2006;131:822–829
  29. Wisnivesky JP, Henschke CI, Yankelevitz DF. Diagnostic percutaneous transthoracic needle biopsy does not affect survival in stage I lung cancer. Am J Respir Crit Care Med. 2006;174:684–688
  30. Spira A, Beane JE, Shah V, et al. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med. 2007;13:361–366
  31. Qiao X, Tullgren O, Lax I, et al. The role of radiotherapy in treatment of stage I non-small cell lung cancer. Lung Cancer. 2003;41:1–11
  32. McGarry RC, Papiez L, Williams M, et al. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: phase I study. Int J Radiat Oncol Biol Phys. 2005;63:1010–1015
  33. Nagata Y, Takayama K, Matsuo Y, et al. Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int J Radiat Oncol Biol Phys. 2005;63:1427–1431
  34. Miyamoto T, Baba M, Yamamoto N, et al. Curative treatment of stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen. Int J Radiat Oncol Biol Phys. 2007;67:750–758
  35. Martini N, Bains MS, Burt ME, et al. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg. 1995;109:120–129
  36. Timmerman R, McGarry R, Yiannoutsos C, et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24:4833–4839
  37. Linden PA, Yeap BY, Chang MY, et al. Morbidity of lung resection after prior lobectomy: results from the Veterans Affairs National Surgical Quality Improvement Program. Ann Thorac Surg. 2007;83:425–431
  38. Perttunen K, Tasmuth T, Kalso E. Chronic pain after thoracic surgery: A follow-up study. Acta Anaesthesiol Scand. 1999;43:563–567
  39. Gotoda Y, Kambara N, Sakai T, et al. The morbidity, time course and predictive factors for persistent post-thoracotomy pain. Eur J Pain. 2001;5:89–96

 Note—An online CME test for this article can be taken at http://asro.astro.org under Continuing Education.

 Conflict of interest: none.

PII: S0360-3016(07)04468-9

doi: 10.1016/j.ijrobp.2007.10.053

International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 3 , Pages 685-692 , 1 March 2008

Article Tools

* Image Usage & Resolution