International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 4 , Pages 1229-1238 , 15 March 2008

Comparison of Different Strategies to Use Four-Dimensional Computed Tomography in Treatment Planning for Lung Cancer Patients

Received 9 August 2007 ,Revised 3 October 2007 ,Accepted 9 November 2007.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106–130
  2. Rosenzweig KE, Fox JL, Yorke E, et al. Results of a phase I dose-escalation study using three-dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma. Cancer. 2005;103:2118–2127
  3. Belderbos J, Heemsbergen W, Hoogeman M, et al. Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy. Radiother Oncol. 2005;75:157–164
  4. Seppenwoolde Y, Lebesque JV, De Jaeger K, et al. Comparing different NTCP models that predict the incidence of radiation pneumonitis. Normal tissue complication probability. Int J Radiat Oncol Biol Phys. 2003;55:724–735
  5. International Commission on Radiation Units and Measurements. ICRU report 62. Prescribing, recording and reporting photon beam therapy. Bethesda, MD: ICRU; 1999;
  6. Balter JM, Ten Haken RK, Lawrence TS, et al. Uncertainties in CT-based radiation therapy treatment planning associated with patient breathing. Int J Radiat Oncol Biol Phys. 1996;36:167–174
  7. Vedam SS, Keall PJ, Kini VR, et al. Acquiring a four-dimensional computed tomography dataset using an external respiratory signal. Phys Med Biol. 2003;48:45–62
  8. Ford EC, Mageras GS, Yorke E, et al. Respiration-correlated spiral CT: A method of measuring respiratory-induced anatomic motion for radiation treatment planning. Med Phys. 2003;30:88–97
  9. Wolthaus JW, van Herk M, Muller SH, et al. Fusion of respiration-correlated PET and CT scans: Correlated lung tumour motion in anatomical and functional scans. Phys Med Biol. 2005;50:1569–1583
  10. Rietzel E, Liu AK, Doppke KP, et al. Design of 4D treatment planning target volumes. Int J Radiat Oncol Biol Phys. 2006;66:287–295
  11. Keall PJ, Joshi S, Vedam SS, et al. Four-dimensional radiotherapy planning for DMLC-based respiratory motion tracking. Med Phys. 2005;32:942–951
  12. Engelsman M, Sharp GC, Bortfeld T, et al. How much margin reduction is possible through gating or breath hold?. Phys Med Biol. 2005;50:477–490
  13. Wolthaus JW, Schneider C, Sonke JJ, et al. Mid-ventilation CT scan construction from four-dimensional respiration-correlated CT scans for radiotherapy planning of lung cancer patients. Int J Radiat Oncol Biol Phys. 2006;65:1560–1571
  14. van Herk M, Remeijer P, Rasch C, et al. The probability of correct target dosage: Dose-population histograms for deriving treatment margins in radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47:1121–1135
  15. Nijkamp J, Wolthaus JWH, Sonke JJ, et al. Mid-ventilation determination with automatic four-dimensional rigid grey-value registration on respiration-correlated computed tomography scans with moving lung tumours. Presented at the XVth International Conference on the Use of Computers in Radiation Therapy; June 4–7, 2007; Toronto, Ontario, Canada.
  16. Sonke JJ, Lebesque JV, van Herk M. Variability of four dimensional CT patient models. Int J Radiat Oncol Biol Phys. 2008;70:590–598
  17. van Herk M, Witte M, van der Geer J, et al. Biologic and physical fractionation effects of random geometric errors. Int J Radiat Oncol Biol Phys. 2003;57:1460–1471
  18. Witte MG, van der Geer J, Schneider C, et al. The effects of target size and tissue density on the minimum margin required for random errors. Med Phys. 2004;31:3068–3079
  19. Borst GR, Sonke JJ, Betgen A, et al. Kilo-voltage cone-beam computed tomography setup measurements for lung cancer patients: First clinical results and comparison with electronic portal-imaging device. Int J Radiat Oncol Biol Phys. 2007;68:555–561
  20. Sonke JJ, Zijp L, Remeijer P, et al. Respiratory correlated cone beam CT. Med Phys. 2005;32:1176–1186
  21. Wink NM, McNitt-Gray MF, Solberg TD. Optimization of multi-slice helical respiration-correlated CT: The effects of table speed and rotation time. Phys Med Biol. 2005;50:5717–5729
  22. McKenzie A. Defining the PTV and PRV—New ideas about old problems. Radiat Oncol. 2004;73(Suppl. 1):203
  23. Underberg RW, Lagerwaard FJ, Slotman BJ, et al. Use of maximum intensity projections (MIP) for target volume generation in 4DCT scans for lung cancer. Int J Radiat Oncol Biol Phys. 2005;63:253–260
  24. Nelson C, Starkschall G, Chang JY. The potential for dose escalation in lung cancer as a result of systematically reducing margins used to generate planning target volume. Int J Radiat Oncol Biol Phys. 2006;65:573–586
  25. Berbeco RI, Nishioka S, Shirato H, et al. Residual motion of lung tumors in end-of-inhale respiratory gated radiotherapy based on external surrogates. Med Phys. 2006;33:4149–4156
  26. Cui Y, Dy JG, Sharp GC, et al. Robust fluoroscopic respiratory gating for lung cancer radiotherapy without implanted fiducial markers. Phys Med Biol. 2007;52:741–755
  27. Keall PJ, Todor AD, Vedam SS, et al. On the use of EPID-based implanted marker tracking for 4D radiotherapy. Med Phys. 2004;31:3492–3499
  28. Mageras GS, Yorke E. Deep inspiration breath hold and respiratory gating strategies for reducing organ motion in radiation treatment. Semin Radiat Oncol. 2004;14:65–75
  29. Keall PJ, Mageras GS, Balter JM, et al. The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med Phys. 2006;33:3874–3900
  30. Underberg RW, van Sornsen de Koste JR, Slotman BJ, et al. Advantages of respiration-gated radiotherapy for stage III lung cancer. [Abstract] Int J Radiat Oncol Biol Phys. 2005;63(Suppl. 1):S415
  31. Guckenberger M, Wilbert J, Meyer J, et al. Is a single respiratory correlated 4D-CT study sufficient for evaluation of breathing motion?. Int J Radiat Oncol Biol Phys. 2007;67:1352–1359
  32. Engelsman M, Damen EM, De Jaeger K, et al. The effect of breathing and set-up errors on the cumulative dose to a lung tumor. Radiother Oncol. 2001;60:95–105
  33. Seppenwoolde Y, Shirato H, Kitamura K, et al. Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. Int J Radiat Oncol Biol Phys. 2002;53:822–834
  34. Hemmendorff M, Andersson MT, Kronander T, et al. Phase-based multidimensional volume registration. IEEE Trans Med Imaging. 2002;21:1536–1543
  35. Wolthaus JWH, Sonke JJ, van Herk M, et al. Motion estimation and compensating in 4D CT images using phase-based constraint models. Presented at the XVth International Conference on the Use of Computers in Radiation Therapy; June 4–7, 2007; Toronto, Ontario, Canada.
  36. Korreman S, Juhler-Nottrup T, Boyer A. Respiratory gated beam delivery cannot facilitate margin reduction, unless combined with respiratory correlated image guidance. Radiat Oncol. 2007;84(Suppl. 1):S87
  37. Rossi M, Beek D, van Belderbos J, et al. Intrafraction motion during frameless stereotactic body radiotherapy of lung cancer patients. Radiat Oncol. 2007;84(Suppl. 1):102

 Supported by a grant from the Dutch Cancer Society (NKI 03-2943).

 Presented in part at the 2006 (Leipzig, Germany) and 2007 (Barcelona, Spain) Annual Meetings of the European Society for Therapeutic Radiology and Oncology (ESTRO).

 Conflict of interest: J.-J. Sonke is partly sponsored by Elekta Oncology Systems.

PII: S0360-3016(07)04592-0

doi: 10.1016/j.ijrobp.2007.11.042

International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 4 , Pages 1229-1238 , 15 March 2008

Article Tools

* Image Usage & Resolution