International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 4 , Pages 974-977 , 15 March 2008

Radiation Retinopathy Is Treatable With Anti–Vascular Endothelial Growth Factor Bevacizumab (Avastin)

  • Paul T. Finger, M.D.

      Affiliations

    • Corresponding Author InformationReprint requests to: Paul T. Finger, M.D., The New York Eye Cancer Center, 115 East 61st Street, New York, NY 10065. Tel: (212) 832-8170; Fax: (212) 888–4030

Received 27 November 2007 ,Revised 30 November 2007 ,Accepted 30 November 2007.

References 

  1. Finger PT. Radiation therapy for choroidal melanoma. Surv Ophthalmol. 1997;42:215–232
  2. Parsons JT, Bova FJ, Fitzgerald CR, et al. Radiation retinopathy after external-beam irradiation: analysis of time-dose factors. Int J Radiat Oncol Biol Phys. 1994;30:765–773
  3. Gardiner TA, Amoaku WM, Archer DB. The combined effect of diabetes and ionising radiation on the retinal vasculature of the rat. Curr Eye Res. 1993;12:1009–1014
  4. Finger PT, Murphree AL. Ophthalmic brachytherapy: Treatment of choroidal melanoma and retinoblastoma. In:  Peyman GA,  Meffert S,  Conway MD, et al. editor. Vitreoretinal surgical techniques. London: Martin Dunitz; 2001;p. 403–418
  5. Archer DB, Amoaku WM, Gardiner TA. Radiation retinopathy—clinical, histopathological, ultrastructural and experimental correlations. Eye. 1991;5(Pt 2):239–251
  6. Ferrara N. Vascular endothelial growth factor: Basic science and clinical progress. Endocr Rev. 2004;25:581–611
  7. Finger PT. Anti-VEGF bevacizumab (Avastin) for radiation optic neuropathy. Am J Ophthalmol. 2007;143:335–338
  8. Finger PT, Chin K. Anti-vascular endothelial growth factor bevacizumab (avastin) for radiation retinopathy. Arch Ophthalmol. 2007;125:751–756
  9. Rickham PP. Human experimentation. Code of ethics of the World Medical Association. Declaration of Helsinki. Br Med J. 1964;2:177
  10. Conn J. HIPPA, 10 years after. Modern Healthcare. 2006;36:26–28
  11. Haik B, Ainbinder DJ, Finger PT, et al. Part X: Ophthalmic sites [carcinoma of the eyelid, carcinoma of the conjunctiva, malignant melanoma of the conjunctiva, malignant melanoma of the uvea, retinoblastoma, carcinoma of the lacrimal gland, sarcoma of the orbit]. In:  Greene FL,  Page DL,  Fleming ID, et al. editor. AJCC cancer staging manual. 6th ed.. New York: Springer-Verlag; 2002;p. 347–384
  12. Finger PT, Berson A, Ng T, et al. Palladium-103 plaque radiotherapy for choroidal melanoma: An 11-year study. Int J Radiat Oncol Biol Phys. 2002;54:1438–1445
  13. Finger PT, Kurli M. Laser photocoagulation for radiation retinopathy after ophthalmic plaque radiation therapy. Br J Ophthalmol. 2005;89:730–738
  14. Levy RL, Miller NR. Hyperbaric oxygen therapy for radiation-induced optic neuropathy. Ann Acad Med Singapore. 2006;35:151–157
  15. Rosenfeld PJ, Schwartz SD, Blumenkranz MS, et al. Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration. Ophthalmology. 2005;112:1048–1053

 Supported by The EyeCare Foundation, New York, NY.

 Presented in part at The American Academy of Ophthalmology Annual Meeting, November 12, 2007, New Orleans, LA.

 Conflict of interest: none.

PII: S0360-3016(07)04662-7

doi: 10.1016/j.ijrobp.2007.11.045

International Journal of Radiation Oncology * Biology * Physics
Volume 70, Issue 4 , Pages 974-977 , 15 March 2008

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