International Journal of Radiation Oncology * Biology * Physics
Volume 71, Issue 5 , Pages 1322-1328 , 1 August 2008

Image Guidance Based on Prostate Position for Prostate Cancer Proton Therapy

  • Carlos Vargas, M.D.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
    • Corresponding Author InformationReprint requests to: Carlos Vargas, M.D., Department of Radiation Oncology, University of Florida Proton Therapy Institute, 2015 N. Jefferson St., Jacksonville, FL 32206. Tel: (904) 588-1800; Fax: (904) 588-1300
  • ,
  • Marcus Wagner, M.D.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • Daniel Indelicato, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
  • ,
  • Amber Fryer, B.S.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • David Horne, C.M.D.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • Angela Chellini, B.S.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • Craig McKenzie, C.M.D.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • Paula Lawlor, C.M.D.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • Chaitali Mahajan, M.D.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • Zuofeng Li, D.Sc.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • Liyong Lin, Ph.D.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL
  • ,
  • Sameer Keole, M.D.

      Affiliations

    • University of Florida Proton Therapy Institute, Jacksonville, FL

Received 25 June 2007 ,Revised 6 December 2007 ,Accepted 6 December 2007.

References 

  1. Yan D, Lockman D, Brabbins D, et al. An off-line strategy for constructing a patient-specific planning target volume in adaptive treatment process for prostate cancer. Int J Radiat Oncol Biol Phys. 2000;48:289–302
  2. Yan D, Xu B, Lockman D, et al. The influence of interpatient and intrapatient rectum variation on external beam treatment of prostate cancer. Int J Radiat Oncol Biol Phys. 2001;51:1111–1119
  3. Yan D, Lockman D, Martinez A, et al. Computed tomography guided management of interfractional patient variation. Semin Radiat Oncol. 2005;15:168–179
  4. Stasi M, Munoz F, Fiorino C, et al. Emptying the rectum before treatment delivery limits the variations of rectal dose–volume parameters during 3DCRT of prostate cancer. Radiother Oncol. 2006;80:363–370
  5. Schallenkamp JM, Herman MG, Kruse JJ, et al. Prostate position relative to pelvic bony anatomy based on intraprostatic gold markers and electronic portal imaging. Int J Radiat Oncol Biol Phys. 2005;63:800–811
  6. Meijer GJ, Rasch C, Remeijer P, et al. Three-dimensional analysis of delineation errors, setup errors, and organ motion during radiotherapy of bladder cancer. Int J Radiat Oncol Biol Phys. 2003;55:1277–1287
  7. Litzenberg DW, Balter JM, Hadley SW, et al. Influence of intrafraction motion on margins for prostate radiotherapy. Int J Radiat Oncol Biol Phys. 2006;65:548–553
  8. Kupelian PA, Langen KM, Zeidan OA, et al. Daily variations in delivered doses in patients treated with radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2006;66:876–882
  9. Kupelian P, Willoughby T, Mahadevan A, et al. Multi-institutional clinical experience with the Calypso system in localization and continuous, real-time monitoring of the prostate gland during external radiotherapy. Int J Radiat Oncol Biol Phys. 2007;67:1088–1098
  10. Fokdal L, Honore H, Hoyer M, et al. Impact of changes in bladder and rectal filling volume on organ motion and dose distribution of the bladder in radiotherapy for urinary bladder cancer. Int J Radiat Oncol Biol Phys. 2004;59:436–444
  11. Martinez A, Vargas C, Kestin L, et al. Interim results of a phase II dose escalating trial with image guided adaptive radiotherapy for the treatment of early to high risk prostate cancer patients: Improved outcome with increased EBRT doses. Int J Radiat Oncol Biol Phys. 2005;63:S305–S306
  12. Vargas C, Yan D, Kestin LL, et al. Phase II dose escalation study of image-guided adaptive radiotherapy for prostate cancer: Use of dose-volume constraints to achieve rectal isotoxicity. Int J Radiat Oncol Biol Phys. 2005;63:141–149
  13. Vargas C, Martinez A, Kestin LL, et al. Dose–volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:1297–1308
  14. Kupelian PA, Thakkar VV, Khuntia D, et al. Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Long-term outcomes. Int J Radiat Oncol Biol Phys. 2005;63:1463–1468
  15. Letourneau D, Martinez AA, Lockman D, et al. Assessment of residual error for online cone-beam CT-guided treatment of prostate cancer patients. Int J Radiat Oncol Biol Phys. 2005;62:1239–1246
  16. Moseley DJ, White EA, Wiltshire KL, et al. Comparison of localization performance with implanted fiducial markers and cone-beam computed tomography for on-line image-guided radiotherapy of the prostate. Int J Radiat Oncol Biol Phys. 2007;67:942–953
  17. Serago CF, Chungbin SJ, Buskirk SJ, et al. Initial experience with ultrasound localization for positioning prostate cancer patients for external beam radiotherapy. Int J Radiat Oncol Biol Phys. 2002;53:1130–1138
  18. Serago CF, Buskirk SJ, Igel TC, et al. Comparison of daily megavoltage electronic portal imaging or kilovoltage imaging with marker seeds to ultrasound imaging or skin marks for prostate localization and treatment positioning in patients with prostate cancer. Int J Radiat Oncol Biol Phys. 2006;65:1585–1592
  19. Madsen BL, Hsi RA, Pham HT, et al. Intrafractional stability of the prostate using a stereotactic radiotherapy technique. Int J Radiat Oncol Biol Phys. 2003;57:1285–1291
  20. Nederveen AJ, Dehnad H, van der Heide UA, et al. Comparison of megavoltage position verification for prostate irradiation based on bony anatomy and implanted fiducials. Radiother Oncol. 2003;68:81–88
  21. Scarbrough TJ, Golden NM, Ting JY, et al. Comparison of ultrasound and implanted seed marker prostate localization methods: Implications for image-guided radiotherapy. Int J Radiat Oncol Biol Phys. 2006;65:378–387
  22. Soete G, De Cock M, Verellen D, et al. X-ray-assisted positioning of patients treated by conformal arc radiotherapy for prostate cancer: Comparison of setup accuracy using implanted markers versus bony structures. Int J Radiat Oncol Biol Phys. 2007;67:823–827
  23. van den Huevel F, Powell T, Seppi E, et al. Independent verification of ultrasound based image-guided radiation treatment, using electronic portal imaging and implanted gold markers. Med Phys. 2003;30:2878–2887
  24. van der Heide UA, Kotte AN, Dehnad H, et al. Analysis of fiducial marker-based position verification in the external beam radiotherapy of patients with prostate cancer. Radiother Oncol. 2007;82:38–45
  25. Wu J, Haycocks T, Alasti H, et al. Positioning errors and prostate motion during conformal prostate radiotherapy using on-line isocentre set-up verification and implanted prostate markers. Radiother Oncol. 2001;61:127–133
  26. Willoughby TR, Kupelian PA, Pouliot J, et al. Target localization and real-time tracking using the Calypso 4D localization system in patients with localized prostate cancer. Int J Radiat Oncol Biol Phys. 2006;65:528–534
  27. Paganetti H. Monte Carlo calculations for absolute dosimetry to determine machine outputs for proton therapy fields. Phys Med Biol. 2006;51:2801–2812
  28. Lu HM, Kooy H. Optimization of current modulation function for proton spread-out Bragg peak fields. Med Phys. 2006;33:1281–1287
  29. Kempe J, Gudowska I, Brahme A. Depth absorbed dose and LET distributions of therapeutic 1H, 4He, 7Li, and 12C beams. Med Phys. 2007;34:183–192
  30. Palmans H, Verhaegen F. Assigning nonelastic nuclear interaction cross sections to Hounsfield units for Monte Carlo treatment planning of proton beams. Phys Med Biol. 2005;50:991–1000
  31. Schneider U, Pemler P, Besserer J, et al. Patient specific optimization of the relation between CT-Hounsfield units and proton stopping power with proton radiography. Med Phys. 2005;32:195–199
  32. Zhang X, Dong L, Lee AK, et al. Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatment. Int J Radiat Oncol Biol Phys. 2007;67:620–629
  33. Kestin L, Goldstein N, Vicini F, et al. Treatment of prostate cancer with radiotherapy: Should the entire seminal vesicles be included in the clinical target volume?. Int J Radiat Oncol Biol Phys. 2002;54:686–697
  34. van Herk M, Remeijer P, Lebesque JV. Inclusion of geometric uncertainties in treatment plan evaluation. Int J Radiat Oncol Biol Phys. 2002;52:1407–1422
  35. Ciangaru G, Polf JC, Bues M, et al. Benchmarking analytical calculations of proton doses in heterogeneous matter. Med Phys. 2005;32:3511–3523
  36. Dearnaley DP, Hall E, Lawrence D, et al. Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects. Br J Cancer. 2005;92:488–498
  37. Peeters ST, Heemsbergen WD, Koper PC, et al. Dose-response in radiotherapy for localized prostate cancer: Results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy. J Clin Oncol. 2006;24:1990–1996
  38. Pollack A, Zagars GK, Starkschall G, et al. Prostate cancer radiation dose response: Results of the M.D. Anderson phase III randomized trial. Int J Radiat Oncol Biol Phys. 2002;53:1097–1105
  39. Sathya JR, Davis IR, Julian JA, et al. Randomized trial comparing iridium implant plus external-beam radiation therapy with external-beam radiation therapy alone in node-negative locally advanced cancer of the prostate. J Clin Oncol. 2005;23:1192–1199
  40. Shipley WU, Verhey LJ, Munzenrider JE, et al. Advanced prostate cancer: The results of a randomized comparative trial of high dose irradiation boosting with conformal protons compared with conventional dose irradiation using photons alone. Int J Radiat Oncol Biol Phys. 1995;32:3–12
  41. Vargas CE, Martinez AA, Boike TP, et al. High-dose irradiation for prostate cancer via a high-dose-rate brachytherapy boost: Results of a phase I to II study. Int J Radiat Oncol Biol Phys. 2006;66:416–423
  42. Zietman AL, DeSilvio ML, Slater JD, et al. Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: A randomized controlled trial. JAMA. 2005;294:1233–1239
  43. Thomas SJ. Margins for treatment planning of proton therapy. Phys Med Biol. 2006;51:1491–1501
  44. van Herk M, Bruce A, Kroes AP, et al. Quantification of organ motion during conformal radiotherapy of the prostate by three dimensional image registration. Int J Radiat Oncol Biol Phys. 1995;33:1311–1320

 Conflict of interest: none.

PII: S0360-3016(07)04708-6

doi: 10.1016/j.ijrobp.2007.12.016

International Journal of Radiation Oncology * Biology * Physics
Volume 71, Issue 5 , Pages 1322-1328 , 1 August 2008