International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 1 , Pages 19-23 , 1 September 2008

Long-Term Survival in Patients With Synchronous, Solitary Brain Metastasis From Non–Small-Cell Lung Cancer Treated With Radiosurgery

  • Todd W. Flannery, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Mohan Suntharalingam, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • William F. Regine, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Lawrence S. Chin, M.D.

      Affiliations

    • Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Mark J. Krasna, M.D.

      Affiliations

    • Department of Thoracic Surgery, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Michael K. Shehata, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Kentucky School of Medicine, Lexington, KY
    • ,
  • Martin J. Edelman, M.D.

      Affiliations

    • Department of Medical Oncology, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Marnie Kremer, B.A.

      Affiliations

    • Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Roy A. Patchell, M.D.

      Affiliations

    • Department of Neurosurgery, University of Kentucky School of Medicine, Lexington, KY
    • ,
  • Young Kwok, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
    • Corresponding Author InformationReprint requests to: Young Kwok, M.D., Department of Radiation Oncology, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201. Tel: (410) 328-9134; Fax: (410) 328-5279

Received 8 November 2007 ,Revised 6 December 2007 ,Accepted 11 December 2007.

References 

  1. Gaspar L, Scott C, Rottman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology (RTOG) brain metastasis trials. Int J Radiat Oncol Biol Phys. 1997;37:745–751
  2. Posner JB. Management of brain metastases. Rev Neurol. 1992;148:477–487
  3. Wen PY, Loeffler JS. Management of brain metastasis. Oncology. 1999;13:941–954
  4. Schouten LJ, Rutten J, Huveneers HA, et al. Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, lung, and melanoma. Cancer. 2002;94:2698–2705
  5. Lagerwaard FJ, Levendag PC, Nowak PJ, et al. Identification of prognostic factors in patients with brain metastases: a review of 1292 patients. Int J Radiat Oncol Biol Phys. 1999;43:795–803
  6. Sorensen JB, Hansen HH, Hansen M, et al. Brain metastases in adenocarcinoma of the lung: frequency, risk groups and prognosis. J Clin Oncol. 1988;6:1474–1480
  7. Bonnette P, Puyo P, Gabriel C, et al. Surgical management of non-small cell lung cancer with synchronous brain metastases. Chest. 2001;119:1469–1475
  8. Billing PS, Miller DL, Allen MS, et al. Surgical treatment of primary lung cancer with synchronous brain metastases. J Thorac Cardiovasc Surg. 2001;122:548–553
  9. Lindquist C. Gamma knife radiosurgery. Semin Radiat Oncol. 1995;5:197–202
  10. Wu A, Lindner G, maitz AH, et al. Physics of gamma knife approach on convergent beams in stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 1990;18:941–949
  11. Hu C, Chang E, Hassenbusch SJ, et al. Nonsmall cell lung cancer presenting with synchronous solitary brain metastasis. Cancer. 2006;106:1998–2004
  12. Tendulkar RD, Liu SW, Barnett , et al. RPA classification has significant prognostic significance for surgically resected single brain metastasis. Int J Radiat Oncol Biol Phys. 2006;66:810–817
  13. Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single brain metastases to the brain. N Engl J Med. 1990;822:494–500
  14. Schellinger PD, Meinck HM, Thron A. Diagnostic accuracy of MRI compared to CCT in patients with brain metastases. J Neurooncol. 1999;44:275–281
  15. Schrevens L, Lorent N, Dooms C, et al. The role of PET scan in diagnosis, staging and management of non-small cell lung cancer. Oncologist. 2004;9:633–643

 Presented at the 48th Annual Meeting of the American Society of Therapeutic Radiology and Oncology (ASTRO), Philadelphia, PA, November 5–9, 2006.

 Conflict of interest: none.

PII: S0360-3016(07)04771-2

doi: 10.1016/j.ijrobp.2007.12.031

International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 1 , Pages 19-23 , 1 September 2008

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