International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 2 , Pages 390-397 , 1 October 2008

Hypofractionation Regimens for Stereotactic Radiotherapy for Large Brain Tumors

  • Jiankui Yuan, Ph.D.

      Affiliations

    • Department of Radiation Medicine, The Ohio State University, Columbus, OH
    • ,
  • Jian Z. Wang, Ph.D.

      Affiliations

    • Department of Radiation Medicine, The Ohio State University, Columbus, OH
    • Corresponding Author InformationReprint requests to: Jian Z. Wang, Ph.D., Department of Radiation Medicine, James Cancer Hospital and Solove Research Institute, The Ohio State University, 300 West 10th Ave., Rm. 094, Columbus, OH 43210. Tel: (614) 293-6502; Fax: (614) 293-4044
    • ,
  • Simon Lo, M.D.

      Affiliations

    • Department of Radiation Medicine, The Ohio State University, Columbus, OH
    • ,
  • John C. Grecula, M.D.

      Affiliations

    • Department of Radiation Medicine, The Ohio State University, Columbus, OH
    • ,
  • Mario Ammirati, M.D.

      Affiliations

    • Department of Neurosurgery, The Ohio State University, Columbus, OH
    • ,
  • Joseph F. Montebello, M.D.

      Affiliations

    • Department of Radiation Medicine, The Ohio State University, Columbus, OH
    • ,
  • Hualin Zhang, Ph.D.

      Affiliations

    • Department of Radiation Medicine, The Ohio State University, Columbus, OH
    • ,
  • Nilendu Gupta, Ph.D.

      Affiliations

    • Department of Radiation Medicine, The Ohio State University, Columbus, OH
    • ,
  • William T.C. Yuh, M.D., M.S.E.E.

      Affiliations

    • Department of Radiology, The Ohio State University, Columbus, OH
    • ,
  • Nina A. Mayr, M.D.

      Affiliations

    • Department of Radiation Medicine, The Ohio State University, Columbus, OH

Received 23 October 2007 ,Accepted 28 December 2007.

References 

  1. David WA, Charles BS, Paul WS, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomized trial. Lancet. 2004;363:1665–1672
  2. Elisa YS, Gustavo AV, Robson F, et al. Whole brain radiation therapy in management of brain metastasis: Results and prognostic factors. Radiat Oncol. 2006;1:20
  3. Sperduto PW. A review of stereotactic radiosurgery in the management of brain metastases. Technol Cancer Res Treat. 2003;2:105–110
  4. Stafinski T, Jhangri GS, Yan E, et al. Effectiveness of stereotactic radiosurgery alone or in combination with whole brain radiotherapy compared to conventional surgery and/or whole brain radiotherapy for the treatment of one or more brain metastases: A systematic review and meta-analysis. Cancer Treat Rev. 2006;32:203–213
  5. Vladimir I, Michael M, Ajay S, et al. Radiosurgical treatment of brain metastases in a community oncologic practice. Commun Oncol. 2004;1:149–158
  6. Edward S, Charles S, Luis S, et al. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: Final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys. 2000;47:291–298
  7. Jason S, Houglas K, John FL, et al. Radiosurgery for patients with metastasis to the brain. Techn Neurosurg. 2003;9:152–160
  8. Aoki M, Abe Y, Hatayama Y, et al. Clinical outcome of hypofractionated conventional conformation radiotherapy for patients with single and no more than three metastatic brain tumors, with noninvasive fixation of the skull without whole brain irradiation. Int J Radiat Oncol Biol Phys. 2006;64:414–418
  9. Aoyama H, Shirato H, Onimaru R, et al. Hypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastases using noninvasive fixation of the skull. Int J Radiat Oncol Biol Phys. 2003;56:793–800
  10. Lindvall P, Bergstrom P, Lofroth P, et al. Hypofractionated conformal stereotactic radiotherapy alone or in combination with whole-brain radiotherapy in patients with cerebral metastases. Int J Radiat Oncol Biol Phys. 2005;61:1460–1466
  11. Manning M, Cardinale R, Benedict S, et al. Hypofractionated stereotactic radiotherapy as an alternative to radiosurgery for the treatment of patients with brain metastases. Int J Radiat Oncol Biol Phys. 2000;47:603–608
  12. Nathan SF, Shiao YW, Bin ST, et al. Hypofractionated intensity-modulated radiotherapy for primary glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2004;58:721–726
  13. David RW. Applied radiobiology and bioeffect planning. Medical Physics Publishing; 2001;
  14. Webb S. Converting 3D dose to biological outcomes: Tumor control probabilities (TCP) and normal tissue complication probabilities (NTCP). In:  Mould RF,  Orton CG,  Spaan JAE, et al. editor. The physics of conformal radiotherapy: Advances in technology. Boca Raton, FL: CRC Press; 1997;p. 258–287
  15. Liu L, Bassano DA, Prasad SC, et al. The linear-quadratic model and fractionated stereotactic radiotherapy. Int J Radiat Oncol Biol Phys. 2003;57:827–832
  16. Brenner DJ, Martel MK, Hall EJ. Fractionated regimens for stereotactic radiotherapy of recurrent tumors in the brain. Int J Radiat Oncol Biol Phys. 1991;21:819–824
  17. Leibel SA, Gutin PH, Wara WM, et al. Survival and quality of life after interstitial implantation of removable high-activity iodine-125 sources for the treatment of patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 1989;17:1129–1139
  18. Dale R. The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy. Br J Radiol. 1985;58:515–528
  19. Dale R. Radiobiological assessment of permanent implants using tumor repopulation factors in linear-quadratic model. Br J Radiol. 1989;62:241–244
  20. Eric JH, Amato JG. Radiobiology for the radiologist. Philadelphia: Lippincott Williams & Wilkins; 2006;p. 391–393
  21. Niemierko A. Reporting and analyzing dose distribution: A concept of equivalent uniform dose. Med Phys. 1997;24:103–110
  22. Niemierko A. A generalized concept of equivalent uniform dose (EUD) (Abstract). Med Phys. 1999;26:1100
  23. Wu QW, Mohan R, Niemierko A, et al. Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose. Int J Radiat Oncol Biol Phys. 2002;224–235
  24. Wang JZ, Li XA. Evaluation of external beam radiotherapy and brachytherapy for localized prostate cancer using equivalent uniform dose. Med Phys. 2003;30:34–40
  25. Li XA, Wang JZ, Stewart RD, et al. Dose escalation in permanent brachytherapy for prostate cancer: dosimetric and biological considerations. Phys Med Biol. 2003;48:2753–2765
  26. Wang JZ, Li XA, D'Souza WD, et al. Impact of prolonged fraction delivery times on tumor control: A note of caution for intensity-modulated radiation therapy (IMRT). Int J Radiat Oncol Biol Phys. 2003;57:543–552
  27. Dennis CS, Lisa H, Kenneth B, et al. Dose fractionation in stereotactic radiotherapy for parasellae meningiomas: Radiobiological considerations of efficacy and optic nerve tolerance. J Neurosurg. 2004;101(Suppl. 3):390–395
  28. Kutcher GJ, Burman C. Calculation probability factors for non-uniform normal tissue irradiation: The effective volume method. Int J Radiat Oncol Biol Phys. 1989;16:1623–1630
  29. Lyman JT. Complication probability—As assessed from dose volume histograms. Radiat Res. 1985;104:S13–S19
  30. Emami B, Lyman J, Brown A, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 1991;21:109–122
  31. Kondziolka D, Patel A, Lunsford LD, et al. Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys. 1999;45:427–434
  32. Burman C, Kutcher GJ, Emami B, et al. Fitting of normal tissue tolerance data to an analytic function. Int J Radiat Oncol Biol Phys. 1991;21:123–135

 Conflict of interest: none.

PII: S0360-3016(08)00031-X

doi: 10.1016/j.ijrobp.2007.12.039

International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 2 , Pages 390-397 , 1 October 2008

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