International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 1 , Pages 15-23 , 1 January 2009

Radiotherapy and Survival in Prostate Cancer Patients: A Population-Based Study

  • Esther H. Zhou, M.D., Ph.D.

      Affiliations

    • Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH
    • Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH
    • Corresponding Author InformationReprint requests to: Esther Hang Zhou, M.D., Department of Urology, Case School of Medicine, 11100 Euclid Ave., Lakeside Room 4560, Cleveland, OH 44106-5046. Tel: (216) 844-5662; Fax: (216) 844-1900
    • ,
  • Rodney J. Ellis, M.D.

      Affiliations

    • Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH
    • Department of Radiology, Northeastern Ohio Universities College of Medicine, Rootstown, OH
    • ,
  • Edward Cherullo, M.D.

      Affiliations

    • Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH
    • ,
  • Valdir Colussi, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Case Western Reserve University School of Medicine, Cleveland, OH
    • ,
  • Fang Xu, M.S.

      Affiliations

    • Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH
    • ,
  • Wei-Dong Chen, M.D.

      Affiliations

    • Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH
    • Howard Hughes Medical Institute, Cleveland, OH
    • Case Comprehensive Cancer Center, Cancer-Aging Program, Cleveland, OH
    • ,
  • Sanjay Gupta, Ph.D.

      Affiliations

    • Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH
    • ,
  • Christopher C. Whalen, M.D.

      Affiliations

    • Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH
    • ,
  • Donald Bodner, M.D.

      Affiliations

    • Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH
    • ,
  • Martin I. Resnick, M.D.

      Affiliations

    • Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH
    • ,
  • Alfred A. Rimm, Ph.D.

      Affiliations

    • Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH
    • ,
  • Siran M. Koroukian, Ph.D.

      Affiliations

    • Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH
    • Case Comprehensive Cancer Center, Cancer-Aging Program, Cleveland, OH

Received 19 December 2007 ,Revised 6 March 2008 ,Accepted 25 April 2008.

References 

  1. American Cancer Society . Cancer facts and figures, 2007. Atlanta, GA: ACS; 2007;
  2. Thompson I, Thrasher JB, Aus G, et al. Guideline for the management of clinically localized prostate cancer: 2007 update. J Urol. 2007;177:2106–2131
  3. Wilt TJ, Macdonald R, Rutks I, et al. Systematic review: The comparative effectiveness and harms of treatments for clinically localized prostate cancer. Ann Intern Med. 2008;148:435–448
  4. D'Amico AV, Whittington R, Malkowicz SB, et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA. 1998;280:969–974
  5. Potters L, Klein EA, Kattan MW, et al. Monotherapy for stage T1-T2 prostate cancer: Radical prostatectomy, external beam radiotherapy, or permanent seed implantation. Radiother Oncol. 2004;71:29–33
  6. Ciezki JP, Klein EA, Angermeier K, et al. A retrospective comparison of androgen deprivation (AD) vs. no AD among low-risk and intermediate-risk prostate cancer patients treated with brachytherapy, external beam radiation therapy, or radical prostatectomy. Int J Radiat Oncol Biol Phys. 2004;60:1347–1350
  7. Roemeling S, Roobol MJ, Postma R, et al. Management and survival of screen-detected prostate cancer patients who might have been suitable for active surveillance. Eur Urol. 2006;50:475–482
  8. Bracarda S, de Cobelli O, Greco C, et al. Cancer of the prostate. Crit Rev Oncol Hematol. 2005;56:379–396
  9. Bill-Axelson A, Holmberg L, Ruutu M, et al. Radical prostatectomy versus watchful waiting in early CaP. N Engl J Med. 2005;352:1977–1984
  10. Steineck G, Helgesen F, Adolfsson J, et al. Quality of life after radical prostatectomy or watchful waiting. N Engl J Med. 2002;347:790–796
  11. Zeliadt SB, Potosky AL, Etzioni R, et al. Racial disparity in primary and adjuvant treatment for nonmetastatic prostate cancer: SEER-Medicare trends 1991 to 1999. Urology. 2004;64:1171–1176
  12. Denberg TD, Beaty BL, Kim FJ, et al. Marriage and ethnicity predict treatment in localized prostate carcinoma. Cancer. 2005;103:1819–1825
  13. Wong YN, Mitra N, Hudes G, et al. Survival associated with treatment vs observation of localized prostate cancer in elderly men. JAMA. 2006;296:2683–2693
  14. Lu-Yao G, Moore DF, Oleynick JU, et al. Population based study of hormonal therapy and survival in men with metastatic prostate cancer. J Urol. 2007;177:535–539
  15. Sylvester JE, Blasko JC, Grimm PD, et al. Ten-year biochemical relapse-free survival after external beam radiation and brachytherapy for localized prostate cancer: The Seattle experience. Int J Radiat Oncol Biol Phys. 2003;57:944–952
  16. Potters L, Morgenstern C, Calugaru E, et al. 12-year outcomes following permanent prostate brachytherapy in patients with clinically localized prostate cancer. J Urol. 2005;173:1562–1566
  17. Zelefsky MJ, Yamada Y, Fuks Z, et al. Long-term results of conformal radiotherapy for prostate cancer: Impact of dose escalation on biochemical tumor control and distant metastases-free survival outcomes. Int J Radiat Oncol Biol Phys. 2008;71:1028–1033
  18. International classification of disease, 9th revision, clinical modification. New York: McGraw Hill; 1994;
  19. Charlson ME, Sax FL, MacKenzie CR, et al. Morbidity during hospitalization: Can we predict it?. J Chronic Dis. 1987;40:705–712
  20. Holmberg L, Bill-Axelson A, Helgesen F, et al. A randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer. N Engl J Med. 2002;347:781–789
  21. Alibhai SM, Klotz LH. A systematic review of randomized trials in localized prostate cancer. Can J Urol. 2004;11:2110–2117
  22. Albertsen PC, Hanley JA, Fine J. 20-year outcomes following conservative management of clinically localized prostate cancer. JAMA. 2005;293:2095–2101
  23. Kulkarni GS, Lockwood G, Evans A, et al. Clinical predictors of Gleason score upgrading implications for patients considering watchful waiting, active surveillance, or brachytherapy. Cancer. 2007;109:2432–2438
  24. Klotz L. Active surveillance for favorable risk prostate cancer: What are the results, and how safe is it?. Semin Radiat Oncol. 2008;18:2–6
  25. Dall'era MA, Cooperberg MR, Chan JM, et al. Active surveillance for early-stage prostate cancer: Review of the current literature. Cancer. 2008;112:1650–1659
  26. Nilsson S, Norlén BJ, Widmark A. A systematic overview of radiation therapy effects in prostate cancer. Acta Oncol. 2004;43:316–381
  27. Ellis RJ, Zhou EH, Fu P, et al. Single photon emission computerized tomography and computerized tomography image set co-registration plus capromab pendetide independently predicts biochemical failure. J Urol. 2008;179:1768–1773discussion 1773–1774
  28. Stock RG, Ho A, Cesaretti JA, et al. Changing the patterns of failure for high-risk prostate cancer patients by optimizing local control. Int J Radiat Oncol Biol Phys. 2006;66:389–394
  29. Carter HB, Ferrucci L, Kettermann A, et al. Detection of life-threatening prostate cancer with prostate-specific antigen velocity during a window of curability. J Natl Cancer Inst. 2006;98:1521–1527
  30. Merrick GS, Butler WM, Galbreath RW, et al. Relationship between percent positive biopsies and biochemical outcome after permanent interstitial brachytherapy for clinically organ-confined carcinoma of the prostate gland. Int J Radiat Oncol Biol Phys. 2002;52:664–673
  31. Lau WK, Blute ML, Bostwick DG, et al. Prognostic factors for survival of patients with pathological Gleason score 7 prostate cancer: Differences in outcome between primary Gleason grades 3 and 4. J Urol. 2001;166:1692–1697
  32. Rohrmann S, Genkinger JM, Burke A, et al. Smoking and risk of fatal prostate cancer in a prospective U.S. study. Urology. 2007;69:721–725
  33. Park SY, Murphy SP, Wilkens LR, et al. Fat and meat intake and prostate cancer risk: The multiethnic cohort study. Int J Cancer. 2007;121:1339–1345
  34. Whittemore AS, Kolonel LN, Wu AH, et al. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst. 1995;87:652–661
  35. Smith EB, Frierson HF, Mills SE, et al. Gleason scores of prostate biopsy and radical prostatectomy specimens over the past 10 years: Is there evidence for systematic upgrading?. Cancer. 2002;94:2282–2287

 Supported by a Career Development Grant from the National Cancer Institute (K07 CA096705 to S.M.K.), and a National Institutes of Health Cancer-Aging Research Development Grant (P20 CA103736 to Dr. Nathan Berger, Case School of Medicine; S.M.K., pilot project investigator).

 Disclaimer: Cancer incidence data were obtained from the Ohio Cancer Incidence Surveillance System (OCISS), Ohio Department of Health. Use of these data does not imply that the Ohio Department of Health either agrees or disagrees with any presentation, analyses, interpretations, or conclusions. Information about the OCISS may be obtained at www.odh.ohio.gov/odhprograms/svio/ci_surv/ci_surv1.aspx.

 This article is dedicated to Dr. Martin I. Resnick, in memory of a beloved mentor and a devoted supporter of our research.

 Conflict of interest: none.

PII: S0360-3016(08)00547-6

doi: 10.1016/j.ijrobp.2008.04.001

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 1 , Pages 15-23 , 1 January 2009

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