International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 1 , Pages 30-38 , 1 January 2009

Bowel, Urinary, and Sexual Problems Among Long-Term Prostate Cancer Survivors: A Population-Based Study

  • Floortje Mols, Ph.D.

      Affiliations

    • CoRPS—Center of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands
    • Comprehensive Cancer Centre South (CCCS), Eindhoven Cancer Registry, Eindhoven, The Netherlands
    • Corresponding Author InformationReprint requests to: F. Mols, Ph.D., CoRPS, Department of Medical Psychology, Tilburg University, Tilburg, The Netherlands. Tel: (+31) 13-466-3482; Fax: (+31) 13-466-2067
    • ,
  • Ida J. Korfage, Ph.D.

      Affiliations

    • Department of Public Health, Erasmus MC—University Medical Center, Rotterdam, The Netherlands
    • ,
  • Ad J.J.M. Vingerhoets, Ph.D.

      Affiliations

    • Clinical Psychology Section, Tilburg University, Tilburg, The Netherlands
    • ,
  • Paul J.M. Kil, M.D.

      Affiliations

    • Department of Urology, Sint Elisabeth Hospital, Tilburg, The Netherlands
    • ,
  • Jan Willem W. Coebergh, Ph.D.

      Affiliations

    • Comprehensive Cancer Centre South (CCCS), Eindhoven Cancer Registry, Eindhoven, The Netherlands
    • Department of Public Health, Erasmus MC—University Medical Center, Rotterdam, The Netherlands
    • ,
  • Marie-Louise Essink-Bot, Ph.D.

      Affiliations

    • Department of Public Health, Erasmus MC—University Medical Center, Rotterdam, The Netherlands
    • Department of Social Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Lonneke V. van de Poll-Franse, Ph.D.

      Affiliations

    • CoRPS—Center of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands
    • Comprehensive Cancer Centre South (CCCS), Eindhoven Cancer Registry, Eindhoven, The Netherlands

Received 5 March 2008 ,Revised 4 April 2008 ,Accepted 7 April 2008.

References 

  1. Signaleringscommissie-Kanker. Kanker in Nederland. Trends, prognoses en implicaties voor zorgvraag. [Cancer in the Netherlands. Trends, prognosis and implications for health care.]. Amsterdam: KWF Kankerbestrijding; 2004;
  2. Post PN, Kil PJ, Crommelin MA, et al. Trends in incidence and mortality rates for prostate cancer before and after prostate-specific antigen introduction. A registry-based study in southeastern Netherlands, 1971–1995. Eur J Cancer. 1998;34:705–709
  3. Postma R, Schroder FH. Screening for prostate cancer. Eur J Cancer. 2005;41:825–833
  4. Janssen-Heijnen MLG, Louwman WJ, van de Poll-Franse LV, et al. Results of 50 years cancer registry in the South of the Netherlands: 1955–2004. [in Dutch] Eindhoven: Eindhoven Cancer Registry; 2005;
  5. Cancer facts and figures—2000. Atlanta, GA: American Cancer Society; 2000;
  6. Penson DF, Litwin MS, Aaronson NK. Health related quality of life in men with prostate cancer. J Urol. 2003;169:1653–1661
  7. Wei JT, Dunn RL, Sandler HM, et al. Comprehensive comparison of health-related quality of life after contemporary therapies for localized prostate cancer. J Clin Oncol. 2002;20:557–566
  8. Clark JA, Inui TS, Silliman RA, et al. Patients' perceptions of quality of life after treatment for early prostate cancer. J Clin Oncol. 2003;21:3777–3784
  9. Potosky AL, Legler J, Albertsen PC, et al. Health outcomes after prostatectomy or radiotherapy for prostate cancer: Results from the Prostate Cancer Outcomes Study. J Natl Cancer Inst. 2000;92:1582–1592
  10. Madalinska JB, Essink-Bot ML, de Koning HJ, et al. Health-related quality-of-life effects of radical prostatectomy and primary radiotherapy for screen-detected or clinically diagnosed localized prostate cancer. J Clin Oncol. 2001;19:1619–1628
  11. Lim AJ, Brandon AH, Fiedler J, et al. Quality of life: Radical prostatectomy versus radiation therapy for prostate cancer. J Urol. 1995;154:1420–1425
  12. Namiki S, Tochigi T, Kuwahara M, et al. Health related quality of life in Japanese men after radical prostatectomy or radiation therapy for localized prostate cancer. Int J Urol. 2004;11:619–627
  13. Korfage IJ, Essink-Bot ML, Borsboom GJ, et al. Five-year follow-up of health-related quality of life after primary treatment of localized prostate cancer. Int J Cancer. 2005;116:291–296
  14. Lubeck DP, Grossfeld GD, Carroll PR. The effect of androgen deprivation therapy on health-related quality of life in men with prostate cancer. Urology. 2001;58:94–100
  15. Helgason AR, Fredrikson M, Adolfsson J, et al. Decreased sexual capacity after external radiation therapy for prostate cancer impairs quality of life. Int J Radiat Oncol Biol Phys. 1995;32:33–39
  16. Incrocci L, Slob AK, Levendag PC. Sexual (dys)function after radiotherapy for prostate cancer: A review. Int J Radiat Oncol Biol Phys. 2002;52:681–693
  17. Miller DC, Sanda MG, Dunn RL, et al. Long-term outcomes among localized prostate cancer survivors: Health-related quality-of-life changes after radical prostatectomy, external radiation, and brachytherapy. J Clin Oncol. 2005;23:2772–2780
  18. Hamilton AS, Stanford JL, Gilliland FD, et al. Health outcomes after external-beam radiation therapy for clinically localized prostate cancer: Results from the Prostate Cancer Outcomes Study. J Clin Oncol. 2001;19:2517–2526
  19. Fransson P, Widmark A. Late side effects unchanged 4–8 years after radiotherapy for prostate carcinoma: A comparison with age-matched controls. Cancer. 1999;85:678–688
  20. Johnstone PA, Gray C, Powell CR. Quality of life in T1-3N0 prostate cancer patients treated with radiation therapy with minimum 10-year follow-up. Int J Radiat Oncol Biol Phys. 2000;46:833–838
  21. Potosky AL, Davis WW, Hoffman RM, et al. Five-year outcomes after prostatectomy or radiotherapy for prostate cancer: The prostate cancer outcomes study. J Natl Cancer Inst. 2004;96:1358–1367
  22. Meyer JP, Gillatt DA, Lockyer R, et al. The effect of erectile dysfunction on the quality of life of men after radical prostatectomy. BJU Int. 2003;92:929–931
  23. Hanlon AL, Watkins Bruner D, Peter R, et al. Quality of life study in prostate cancer patients treated with three-dimensional conformal radiation therapy: Comparing late bowel and bladder quality of life symptoms to that of the normal population. Int J Radiat Oncol Biol Phys. 2001;49:51–59
  24. Korfage IJ, Roobol M, De Koning HJ, et al. Does “normal” aging imply urinary, bowel and erectile dysfunction? A general population survey. Urology. 2008;72:3–9
  25. International Union Against Cancer . TNM atlas illustrated guide to the TNM/pTNM classification of malignant tumours. 4th ed., 2nd rev. ed.. Berlin: Springer Verlag; 1992;p. 141–144
  26. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chron Dis. 1987;40:373–383
  27. Wei JT, Dunn RL, Litwin MS, et al. Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer. Urology. 2000;56:899–905
  28. Korfage IJ, Essink-Bot ML, Madalinska JB, et al. Measuring disease specific quality of life in localized prostate cancer: The Dutch experience. Qual Life Res. 2003;12:459–464
  29. Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003;41:582–592
  30. Bacon CG, Giovannucci E, Testa M, et al. The association of treatment-related symptoms with quality-of-life outcomes for localized prostate carcinoma patients. Cancer. 2002;94:862–871
  31. Zelefsky MJ, Fuks Z, Happersett L, et al. Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer. Radiother Oncol. 2000;55:241–249
  32. Zelefsky MJ, Fuks Z, Hunt M, et al. High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer. J Urol. 2001;166:876–881
  33. Akakura K, Isaka S, Akimoto S, et al. Long-term results of a randomized trial for the treatment of Stages B2 and C prostate cancer: Radical prostatectomy versus external beam radiation therapy with a common endocrine therapy in both modalities. Urology. 1999;54:313–318
  34. Incrocci L. Sexual function after external-beam radiotherapy for prostate cancer: What do we know?. Crit Rev Oncol Hematol. 2006;57:165–173
  35. Hollenbeck BK, Dunn RL, Wei JT, et al. Determinants of long-term sexual health outcome after radical prostatectomy measured by a validated instrument. J Urol. 2003;169:1453–1457
  36. Potosky AL, Reeve BB, Clegg LX, et al. Quality of life following localized prostate cancer treated initially with androgen deprivation therapy or no therapy. J Natl Cancer Inst. 2002;94:430–437
  37. Schover LR, Fouladi RT, Warneke CL, et al. The use of treatments for erectile dysfunction among survivors of prostate carcinoma. Cancer. 2002;95:2397–2407

 Conflict of interest: none.

PII: S0360-3016(08)00643-3

doi: 10.1016/j.ijrobp.2008.04.004

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 1 , Pages 30-38 , 1 January 2009

Article Tools

* Image Usage & Resolution