International Journal of Radiation Oncology * Biology * Physics
Volume 71, Issue 5 , Pages 1293-1294 , 1 August 2008

Radiation-Induced Side Effects With or Without Systemic Therapies: Prime Time for Prediction of Individual Radiosensitivity

  • David Azria, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, CRLC Val d'Aurelle, Montpellier, France
    • Corresponding Author InformationReprint requests to: David Azria, M.D., Ph.D., Department of Radiation Oncology, Rue Croix Verte, CRLC Val d'Aurelle, 34298 Montpellier, France. Tel: (+33) 4-6761-8579; Fax: (+ 33) 4-6761-3135
    • ,
  • Barry S. Rosenstein, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY, and New York University School of Medicine, New York, NY
    • ,
  • Mahmut Ozsahin, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Received 4 February 2008 ,Revised 10 March 2008 ,Accepted 12 March 2008.

References 

  1. Bartelink H, Horiot JC, Poortmans P, et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-Year results of the randomized boost versus no boost EORTC 22881-10882 Trial. J Clin Oncol. 2007;25:3259–3265
  2. Koc M. What is the impact of tamoxifen on radiation-induced fibrosis in patients receiving breast-conserving therapy. J Clin Oncol. 2007;25:5841;author reply 5844–5845
  3. Colletta AA, Wakefield LM, Howell FV, et al. Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. Br J Cancer. 1990;62:405–409
  4. Canney PA, Dean S. Transforming growth factor beta: A promotor of late connective tissue injury following radiotherapy?. Br J Radiol. 1990;63:620–623
  5. Azria D, Gourgou S, Sozzi WJ, et al. Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients. Br J Cancer. 2004;91:1251–1260
  6. Ozsahin M, Crompton NE, Gourgou S, et al. CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced late toxicity: A prospective study in 399 patients. Clin Cancer Res. 2005;11:7426–7433
  7. Azria D, Pelegrin A, Dubois JB, et al. Radiation therapy and tamoxifen: Concurrent or sequential? It's no longer the question!. J Clin Oncol. 2005;23:4239–4241
  8. Ho AY, Atencio DP, Peters S, et al. Genetic predictors of adverse radiotherapy effects: The Gene-PARE project. Int J Radiat Oncol Biol Phys. 2006;65:646–655
  9. Carlson RW, Hudis CA, Pritchard KI. Adjuvant endocrine therapy in hormone receptor-positive postmenopausal breast cancer: Evolution of NCCN, ASCO, and St Gallen recommendations. J Natl Compr Canc Netw. 2006;4:971–979
  10. Azria D, Larbouret C, Cunat S, et al. Letrozole sensitizes breast cancer cells to ionizing radiation. Breast Cancer Res. 2005;7:R156–R163

 Conflict of interest: none.

PII: S0360-3016(08)00653-6

doi: 10.1016/j.ijrobp.2008.03.057

International Journal of Radiation Oncology * Biology * Physics
Volume 71, Issue 5 , Pages 1293-1294 , 1 August 2008

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