International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 3 , Pages 727-733 , 1 March 2009

Prognosis and Treatment of Spinal Cord Astrocytoma

  • Kiernan J. Minehan, M.D.

      Affiliations

    • Department of Radiation Oncology, Mayo Clinic, Rochester, MN
    • Section of Radiation Oncology, Franciscan Skemp Healthcare, Mayo Health System, La Crosse, WI
    • Corresponding Author InformationReprint requests to: Kiernan J. Minehan, M.D., Department of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905.
  • ,
  • Paul D. Brown, M.D.

      Affiliations

    • Department of Radiation Oncology, Mayo Clinic, Rochester, MN
  • ,
  • Bernd W. Scheithauer, M.D.

      Affiliations

    • Division of Anatomic Pathology, Mayo Clinic, Rochester, MN
  • ,
  • William E. Krauss, M.D.

      Affiliations

    • Division of Surgical Oncology, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN
  • ,
  • Michael P. Wright, B.S.

      Affiliations

    • Student, University of Washington School of Medicine, Seattle, WA

Received 11 February 2008 ,Revised 25 April 2008 ,Accepted 25 April 2008.

References 

  1. Abdel-Wahab M, Etuk B, Palermo J, et al. Spinal cord gliomas: A multi-institutional retrospective analysis. Int J Radiat Oncol Biol Phys. 2006;64:1060–1671Epub 2005 Dec 20
  2. Chun HC, Schmidt-Ullrich RK, Wolfson A, et al. External beam radiotherapy for primary spinal cord tumors. J Neurooncol. 1990;9:211–217
  3. Rodrigues GB, Waldron JN, Wong CS, et al. A retrospective analysis of 52 cases of spinal cord glioma managed with radiation therapy. Int J Radiat Oncol Biol Phys. 2000;48:837–842
  4. Santi M, Mena H, Wong K, et al. Spinal cord malignant astrocytomas: Clinicopathologic features in 36 cases. Cancer. 2003;98:554–561
  5. Cohen AR, Wisoff JH, Allen JC, et al. Malignant astrocytomas of the spinal cord. J Neurosurg. 1989;70:50–54
  6. Cooper PR, Epstein F. Radical resection of intramedullary spinal cord tumors in adults: Recent experience in 29 patients. J Neurosurg. 1985;63:492–499
  7. Epstein FJ, Farmer JP, Freed D. Adult intramedullary astrocytomas of the spinal cord. J Neurosurg. 1992;77:355–359
  8. Minehan KJ, Shaw EG, Scheithauer BW, et al. Spinal cord astrocytoma: Pathological and treatment considerations. J Neurosurg. 1995;83:590–595
  9. Reimer R, Onofrio BM. Astrocytomas of the spinal cord in children and adolescents. J Neurosurg. 1985;63:669–675
  10. Louis DN, Ohgaki H, Wiestler OD, et al. WHO classification of tumours of the central nervous system. 4th ed.. Geneva: WHO Press; 2007;
  11. Daumas-Duport C, Scheithauer B, O'Fallon J, et al. Grading of astrocytomas: A simple and reproducible method. Cancer. 1988;62:2152–2165
  12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  13. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 1966;50:163–170
  14. Cox DR. Regression models and life-tables. J R Stat Soc B. 1972;34:187–220
  15. Harrell FE, Lee KL, Califf RM, et al. Regression modelling strategies for improved prognostic prediction. Stat Med. 1984;3:143–152
  16. Sandler HM, Papadopoulos SM, Thornton AF, et al. Spinal cord astrocytomas: Results of therapy. Neurosurgery. 1992;30:490–493
  17. Willman KY, Cox RS, Donaldson SS. Radiation induced height impairment in pediatric Hodgkin's disease. Int J Radiat Oncol Biol Phys. 1994;28:85–92
  18. Cooper PR. Outcome after operative treatment of intramedullary spinal cord tumors in adults: Intermediate and long-term results in 51 patients. Neurosurgery. 1989;25:855–859
  19. Stupp R, Mason WP, van den Bent MJ, et al. European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and National Cancer Institute of Canada Clinical Trials Group Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987–996
  20. Mora J, Cruz O, Gala S, et al. Successful treatment of childhood intramedullary spinal cord astrocytomas with irinotecan and cisplatin. Neurooncology. 2007;9:39–46Epub 2006 Nov 15

 Presented at the 2007 American Society for Therapeutic Radiology and Oncology 49th Annual Meeting, Los Angeles, CA, October 28 to November 1, 2007, and the 12th Annual Scientific Meeting of the Society of Neurooncology, Dallas, TX, November 15–18, 2007.

 Conflict of interest: none.

PII: S0360-3016(08)00820-1

doi: 10.1016/j.ijrobp.2008.04.060

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 3 , Pages 727-733 , 1 March 2009