International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 3 , Pages 734-744 , 1 March 2009

Ten-Year Recurrence Rates in Young Women With Breast Cancer by Locoregional Treatment Approach

  • Beth M. Beadle, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Wendy A. Woodward, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • Corresponding Author InformationReprint requests to: Wendy A. Woodward, M.D., Ph.D., The University of Texas M. D. Anderson Cancer Center, Department of Radiation Oncology, 1515 Holcombe Blvd., Unit 1202, Houston, TX 77030. Tel: (713) 563-2300; Fax: (713) 563-6940
    • ,
  • Susan L. Tucker, Ph.D.

      Affiliations

    • Department of Biostatistics and Applied Mathematics, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Elesyia D. Outlaw, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Pamela K. Allen, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Julia L. Oh, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Eric A. Strom, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • George H. Perkins, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Welela Tereffe, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Tse-Kuan Yu, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Funda Meric-Bernstam, M.D.

      Affiliations

    • Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Jennifer K. Litton, M.D.

      Affiliations

    • Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Thomas A. Buchholz, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Received 29 February 2008 ,Revised 29 April 2008 ,Accepted 29 April 2008.

References 

  1. Nixon AJ, Neuberg D, Hayes DF, et al. Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol. 1994;12:888–894
  2. Kurtz JM, Spitalier JM, Amalric R, et al. Mammary recurrences in women younger than forty. Int J Radiat Oncol Biol Phys. 1988;15:271–276
  3. Kurtz JM, Amalric R, Brandone H, et al. Local recurrence after breast-conserving surgery and radiotherapy. Helv Chir Acta. 1989;55:837–842
  4. Recht A, Connolly JL, Schnitt SJ, et al. The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys. 1988;14:3–10
  5. Clark RM, Whelan T, Levine M, et al. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: An update. Ontario Clinical Oncology Group. J Natl Cancer Inst. 1996;88:1659–1664
  6. Kurtz JM, Jacquemier J, Amalric R, et al. Why are local recurrences after breast-conserving therapy more frequent in younger patients?. J Clin Oncol. 1990;8:591–598
  7. de la Rochefordiere A, Asselain B, Campana F, et al. Age as prognostic factor in premenopausal breast carcinoma. Lancet. 1993;341:1039–1043
  8. Kim SH, Simkovich-Heerdt A, Tran KN, et al. Women 35 years of age or younger have higher locoregional relapse rates after undergoing breast conservation therapy. J Am Coll Surg. 1998;187:1–8
  9. Coulombe G, Tyldesley S, Speers C, et al. Is mastectomy superior to breast-conserving treatment for young women?. Int J Radiat Oncol Biol Phys. 2007;67:1282–1290
  10. Albain KS, Allred DC, Clark GM. Breast cancer outcome and predictors of outcome: Are there age differentials?. J Natl Cancer Inst Monogr. 1994;35–42
  11. Leborgne F, Leborgne JH, Ortega B, et al. Breast conservation treatment of early stage breast cancer: Patterns of failure. Int J Radiat Oncol Biol Phys. 1995;31:765–775
  12. Matthews RH, McNeese MD, Montague ED, et al. Prognostic implications of age in breast cancer patients treated with tumorectomy and irradiation or with mastectomy. Int J Radiat Oncol Biol Phys. 1988;14:659–663
  13. Oh JL, Bonnen M, Outlaw ED, et al. The impact of young age on locoregional recurrence after doxorubicin-based breast conservation therapy in patients 40 years old or younger: How young is “young”?. Int J Radiat Oncol Biol Phys. 2006;65:1345–1352
  14. In:  Greene FL,  Page DL,  Fleming ID, et al. editor. AJCC cancer staging manual. 6th ed.. New York: Wiley-Liss; 2002;
  15. Elkhuizen PH, van de Vijver MJ, Hermans J, et al. Local recurrence after breast-conserving therapy for invasive breast cancer: High incidence in young patients and association with poor survival. Int J Radiat Oncol Biol Phys. 1998;40:859–867
  16. Voogd AC, Nielsen M, Peterse JL, et al. Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: Pooled results of two large European randomized trials. J Clin Oncol. 2001;19:1688–1697
  17. de Bock GH, van der Hage JA, Putter H, et al. Isolated loco-regional recurrence of breast cancer is more common in young patients and following breast conserving therapy: Long-term results of European Organisation for Research and Treatment of Cancer studies. Eur J Cancer. 2006;42:351–356
  18. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005;366:2087–2106
  19. Kronowitz SJ, Robb GL. Breast reconstruction with postmastectomy radiation therapy: Current issues. Plast Reconstr Surg. 2004;114:950–960
  20. Jugenburg M, Disa JJ, Pusic AL, et al. Impact of radiotherapy on breast reconstruction. Clin Plast Surg. 2007;34:29–37abstract v–vi
  21. van der Leest M, Evers L, van der Sangen MJ, et al. The safety of breast-conserving therapy in patients with breast cancer aged < or = 40 years. Cancer. 2007;109:1957–1964

 Presented at the 49th Annual Meeting of the American Society of Therapeutic Radiology and Oncology, Los Angeles, CA, Oct 28–Nov 1, 2007.

 Conflict of interest: none.

PII: S0360-3016(08)00823-7

doi: 10.1016/j.ijrobp.2008.04.078

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 3 , Pages 734-744 , 1 March 2009

Article Tools

* Image Usage & Resolution