International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 3 , Pages 685-691 , 1 March 2009

Role of Intensity-Modulated Radiotherapy in Reducing Toxicity in Dose Escalation for Localized Prostate Cancer

  • Abrahim Al-Mamgani, M.D.

      Affiliations

    • Department of Radiation Oncology, Erasmus Medical Center–Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    • Corresponding Author InformationReprint requests to: Abrahim Al-Mamgani, M.D., Department of Radiation Oncology, Erasmus Medical Center–Daniel den Hoed Cancer Center, Groene Hilledijk 301, Rotterdam 3075 EA The Netherlands. Tel: (+31) 10-7040-704; Fax: (+31) 10-7041-031
    • ,
  • Wilma D. Heemsbergen, Ph.D.

      Affiliations

    • The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • ,
  • Stephanie T.H. Peeters, M.D., Ph.D.

      Affiliations

    • The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • ,
  • Joos V. Lebesque, M.D., Ph.D.

      Affiliations

    • The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Received 3 March 2008 ,Revised 27 April 2008 ,Accepted 30 April 2008.

References 

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  3. Dearnaley DP, Hall E, Lawrence D, et al. Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects. B J Cancer. 2005;92:488–498
  4. Al-Mamgani A, van Putten WLJ, Heemsbergen WD, et al. Update of the Dutch multicenter dose escalation trial of radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. In press.
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  8. Bos LJ, Damen EMF, de Boer RW, et al. Reduction of rectal dose by integration of the boost in the large-field treatment plan for prostate irradiation. Int J Radiat Oncol Biol Phys. 2002;52:254–265
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  11. Peeters STH, Lebesque JV, Heemsbergen WD, et al. Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2006;64:1151–1161
  12. Peeters STH, Hoogeman MS, Heemsbergen WD, et al. Volume and hormonal effects for acute side effects of rectum and bladder during conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2005;63:1142–1152
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  14. Hoogeman MS, Peeters STH, de Bois J, et al. Absolute and relative dose-surface and dose-volume histograms of the bladder: which one is the most invariant under bladder filling changes?. Phys Med Biol. 2005;50:3589–3597
  15. Heemsbergen WD, Peeters STH, Koper PC, et al. Acute and late gastrointestinal toxicity after radiotherapy in prostate cancer patients: Consequential late damage. Int J Radiat Oncol Biol Phys. 2006;60:3–10
  16. Denham JW, O'Brien PC, Dunstan RH, et al. Is there more than one late radiation proctitis syndrome?. Radiother Oncol. 1999;51:43–53
  17. Zelefsky MJ, Levin EJ, Hunt M, et al. Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70:1124–1129
  18. Roach M, Hanks G, Thames H, et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys. 2006;65:965–974
  19. Michalski JM, Purdy JA, Winter K, et al. Preliminary report of toxicity following 3D radiation therapy for prostate cancer on 3DOG/RTOG 9406. Int J Radiat Oncol Biol Phys. 2000;46:391–402
  20. Cheung MR, Tucker SL, Dong L, et al. Investigation of bladder dose and volume factors influencing late urinary toxicity after external beam radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2007;67:1059–1065
  21. Koper PC, Jansen P, van Putten W, et al. Gastrointestinal and genitourinary morbidity after 3D conformal radiotherapy of prostate cancer: Observations of a randomized trial. Int J Radiat Oncol Biol Phys. 2004;73:1–9
  22. Bos LJ, van der Geer J, van Herk M, et al. The sensitivity of dose distributions for organ motion and set-up uncertainties in prostate IMRT. Radiother Oncol. 2005;76:18–26

 Supported by the Dutch Cancer Society (NKB Grants NKI 98-1830 and CKTO 96-10).

 Conflict of interest: none.

PII: S0360-3016(08)00829-8

doi: 10.1016/j.ijrobp.2008.04.063

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 3 , Pages 685-691 , 1 March 2009

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