International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 1 , Pages 34-40 , 1 September 2008

Unilateral and Bilateral Breast Cancer in Women Surviving Pediatric Hodgkin's Disease

  • Swati K. Basu, M.B.B.S., M.P.H., Ph.D.

      Affiliations

    • Department of Community and Preventive Medicine, James P. Wilmot Cancer Center at the University of Rochester, Rochester, NY
  • ,
  • Cindy Schwartz, M.D.

      Affiliations

    • Department of Hematology-Oncology, The Johns Hopkins Hospital, Baltimore, MD
  • ,
  • Susan G. Fisher, Ph.D.

      Affiliations

    • Department of Community and Preventive Medicine, James P. Wilmot Cancer Center at the University of Rochester, Rochester, NY
  • ,
  • Melissa M. Hudson, M.D.

      Affiliations

    • Department of Hematology–Oncology, St. Jude Children's Research Hospital, Memphis, TN
  • ,
  • Nancy Tarbell, M.D.

      Affiliations

    • Department of Pediatric Radiation Oncology, Massachusetts General Hospital, Boston, MA
  • ,
  • Ann Muhs, B.A.

      Affiliations

    • Department of Radiation Oncology, James P. Wilmot Cancer Center at the University of Rochester, Rochester, NY
  • ,
  • Karen J. Marcus, M.D.

      Affiliations

    • Department of Radiation Oncology, Brigham & Women's Hospital, Boston, MA
  • ,
  • Nancy Mendenhall, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida Medical Center, Gainesville, FL
  • ,
  • Peter Mauch, M.D.

      Affiliations

    • Department of Radiation Oncology, Brigham & Women's Hospital, Boston, MA
  • ,
  • Larry E. Kun, M.D.

      Affiliations

    • Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN
  • ,
  • Louis S. Constine, M.D.

      Affiliations

    • Department of Radiation Oncology, James P. Wilmot Cancer Center at the University of Rochester, Rochester, NY
    • Department of Pediatrics, James P. Wilmot Cancer Center at the University of Rochester, Rochester, NY
    • Corresponding Author InformationReprint requests to: Louis S. Constine, M.D., Departments of Radiation Oncology and Pediatrics, University of Rochester Medical Center, 601 Elmwood Avenue Box 647, Rochester, NY 14642. Tel: (585) 275-5622; Fax: (585) 275-1531

Received 1 November 2007 ,Revised 2 April 2008 ,Accepted 14 April 2008.

References 

  1. Dores GM, Metayer C, Curtis RE, et al. Second malignant neoplasms among long-term survivors of Hodgkin's disease: A population-based evaluation over 25 years. J Clin Oncol. 2002;20:3484–3494
  2. Ng AK, Bernardo MV, Weller E, et al. Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: Long-term risks and risk factors. Blood. 2002;100:1989–1996
  3. Aisenberg AC, Finkelstein DM, Doppke KP, et al. High risk of breast carcinoma after irradiation of young women with Hodgkin's disease. Cancer. 1997;79:1203–1210
  4. Henry-Amar M, Somers R. Survival outcome after Hodgkin's disease: A report from the international data base on Hodgkin's disease. Semin Oncol. 1990;17:758–768
  5. Hoppe RT. Hodgkin's disease: Complications of therapy and excess mortality. Ann Oncol. 1997;8(Suppl 1):115–118
  6. Bhatia S, Robison LL, Oberlin O, et al. Breast cancer and other second neoplasms after childhood Hodgkin's disease. N Engl J Med. 1996;334:745–751
  7. Neglia JP, Friedman DL, Yasui Y, et al. Second malignant neoplasms in five-year survivors of childhood cancer: Childhood Cancer Survivor Study. J Natl Cancer Inst. 2001;93:618–629
  8. van Leeuwen FE, Klokman WJ, Veer MB, et al. Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood. J Clin Oncol. 2000;18:487–497
  9. Tinger A, Wasserman TH, Klein EE, et al. The incidence of breast cancer following mantle field radiation therapy as a function of dose and technique. Int J Radiat Oncol Biol Phys. 1997;37:865–870
  10. Tarbell NJ, Gelber RD, Weinstein HJ, et al. Sex differences in risk of second malignant tumours after Hodgkin's disease in childhood. Lancet. 1993;341:1428–1432
  11. van Leeuwen FE, Somers R, Hart AA. Splenectomy in Hodgkin's disease and second leukaemias. Lancet. 1987;2:210–211
  12. Tura S, Fiacchini M, Zinzani PL, et al. Splenectomy and the increasing risk of secondary acute leukemia in Hodgkin's disease. J Clin Oncol. 1993;11:925–930
  13. Metayer C, Lynch CF, Clarke EA, et al. Second cancers among long-term survivors of Hodgkin's disease diagnosed in childhood and adolescence. J Clin Oncol. 2000;18:2435–2443
  14. van Leeuwen FE, Klokman WJ, Stovall M, et al. Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease. J Natl Cancer Inst. 2003;95:971–980
  15. Verhoog LC, Brekelmans CT, Seynaeve C, et al. Survival in hereditary breast cancer associated with germline mutations of BRCA2. J Clin Oncol. 1999;17:3396–3402
  16. Travis LB, Hill DA, Dores GM, et al. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA. 2003;290:465–475
  17. Travis LB. Second cancers: Methods and recent results among patients with Hodgkin's disease. Proc Am Soc Clin Oncol. 2004;425–433
  18. In:  Ries LAG,  Kosary CL,  Hankey BF, et al. editor. SEER cancer statistics review, 1973–1996. Bethesda, MD: National Cancer Institute; 1999;
  19. Miller AB, Howe GR, Sherman GJ, et al. Mortality from breast cancer after irradiation during fluoroscopic examinations in patients being treated for tuberculosis. N Engl J Med. 1989;321:1285–1289
  20. Mackenzie I. Breast cancer following multiple fluoroscopies. Br J Cancer. 1965;19:1–8
  21. Shore RE, Hildreth N, Woodard E, et al. Breast cancer among women given X-ray therapy for acute postpartum mastitis. J Natl Cancer Inst. 1986;77:689–696
  22. Tokunaga M, Land CE, Yamamoto T, et al. Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950–1980. Radiat Res. 1987;112:243–272
  23. Thompson DE, Mabuchi K, Ron E, et al. Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958–1987. Radiat Res. 1994;137(2 Suppl):S17–S67
  24. Guibout C, Adjadj E, Rubino C, et al. Malignant breast tumors after radiotherapy for a first cancer during childhood. J Clin Oncol. 2005;23:197–204
  25. Ang P, Garber JE. Genetic susceptibility for breast cancer—risk assessment and counseling. Semin Oncol. 2001;28:419–433
  26. Gaffney DK, Hemmersmeier J, Holden J, et al. Breast cancer after mantle irradiation for Hodgkin's disease: Correlation of clinical, pathologic, and molecular features including loss of heterozygosity at BRCA1 and BRCA2. Int J Radiat Oncol Biol Phys. 2001;49:539–546
  27. Nichols KE, Heath JA, Friedman D, et al. TP53, BRCA1, and BRCA2 tumor suppressor genes are not commonly mutated in survivors of Hodgkin's disease with second primary neoplasms. J Clin Oncol. 2003;21:4505–4509
  28. Offit K, Gilad S, Paglin S, et al. Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers. Clin Cancer Res. 2002;8:3813–3819
  29. Beaty O, Hudson MM, Greenwald C, et al. Subsequent malignancies in children and adolescents after treatment for Hodgkin's disease. J Clin Oncol. 1995;13:603–609
  30. Hancock SL, Tucker MA, Hoppe RT. Breast cancer after treatment of Hodgkin's disease. J Natl Cancer Inst. 1993;85:25–31
  31. Bhatia S, Yasui Y, Robison LL, et al. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: Report from the Late Effects Study Group. J Clin Oncol. 2003;21:4386–4394
  32. Kenney LB, Yasui Y, Inskip PD, et al. Breast cancer after childhood cancer: A report from the Childhood Cancer Survivor Study. Ann Intern Med. 2004;141:590–597
  33. Kriege M, Brekelmans CT, Boetes C, et al. Efficacy of MRI and mammography for breast–cancer screening in women with a familial or genetic predisposition. N Engl J Med. 2004;351:427–437
  34. Wolden SL, Lamborn KR, Cleary SF, Tate DJ, Donaldson SS. Second cancers following pediatric Hodgkin's disease. J Clin Oncol. 1998;16(2):536–544
  35. Yahalom J, Petrek JA, Biddinger PW, et al. Breast cancer in patients irradiated for Hodgkin's disease: A clinical and pathologic analysis of 45 events in 37 patients. J Clin Oncol. 1992;10:1674–1681
  36. Chaudary MA, Millis RR, Hoskins EO, et al. Bilateral primary breast cancer: A prospective study of disease incidence. Br J Surg. 1984;71:711–714
  37. Obedian E, Fischer DB, Haffty BG. Second malignancies after treatment of early-stage breast cancer: Lumpectomy and radiation therapy versus mastectomy. J Clin Oncol. 2000;18:2406–2412
  38. Harris RE, Lynch HT, Guirgis HA. Familial breast cancer: Risk to the contralateral breast. J Natl Cancer Inst. 1978;60:955–960
  39. Robson M, Gilewski T, Haas B, et al. BRCA-associated breast cancer in young women. J Clin Oncol. 1998;16:1642–1649
  40. Kuhl CK, Schrading S, Leutner CC, et al. Mammography, breast ultrasound, and magnetic resonance imaging for surveillance of women at high familial risk for breast cancer. J Clin Oncol. 2005;23:8469–8476
  41. Verhoog LC, Brekelmans CT, Seynaeve C, et al. Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1. Lancet. 1998;351:316–321
  42. Travis LB, Hill D, Dores GM, et al. Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst. 2005;97:1428–1437
  43. Hill DA, Gilbert E, Dores GM, et al. Breast cancer risk following radiotherapy for Hodgkin lymphoma: Modification by other risk factors. Blood. 2005;106:3358–3365

 Conflict of interest: none.

PII: S0360-3016(08)00838-9

doi: 10.1016/j.ijrobp.2008.04.068

International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 1 , Pages 34-40 , 1 September 2008