International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1077-1081 , 15 March 2009

A Matched-Pair Analysis Comparing Whole-Brain Radiotherapy Plus Stereotactic Radiosurgery Versus Surgery Plus Whole-Brain Radiotherapy and a Boost to the Metastatic Site for One or Two Brain Metastases

  • Dirk Rades, M.D.

      Affiliations

    • Department of Radiation Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
    • Department of Radiation Oncology, University Medical Center, Hamburg, Germany
    • Corresponding Author InformationReprint requests to: Dirk Rades, M.D., Department of Radiation Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, D-23538 Luebeck, Germany. Tel: (+49) 451-500-6661; Fax: (+49) 451-500-3324
    • ,
  • Jan-Dirk Kueter, M.D.

      Affiliations

    • Department of Radiation Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
    • ,
  • Andre Pluemer, M.D.

      Affiliations

    • Department of Radiation Oncology, University Medical Center, Hamburg, Germany
    • ,
  • Theo Veninga, M.D.

      Affiliations

    • Department of Radiation Oncology, Dr. Bernard Verbeeten Institute, Tilburg, The Netherlands
    • ,
  • Steven E. Schild, M.D.

      Affiliations

    • Department of Radiation Oncology, Mayo Clinic Scottsdale, Scottsdale, AZ

Received 23 March 2008 ,Revised 6 May 2008 ,Accepted 8 May 2008.

References 

  1. Nieder C, Nestle U, Motaref B, et al. Prognostic factors in brain metastases: Should patients be selected for aggressive treatment according to recursive partitioning analysis (RPA) classes?. Int J Radiat Oncol Biol Phys. 2000;46:297–302
  2. Weltman E, Salvajoli JV, Brandt RA, et al. Radiosurgery for brain metastases: A score index for predicting prognosis. Int J Radiat Oncol Biol Phys. 2000;46:1155–1161
  3. Schoggl A, Kitz K, Reddy M, et al. Defining the role of stereotactic radiosurgery versus microsurgery in the treatment of single brain metastases. Acta Neurochir (Wien). 2000;142:621–626
  4. O'Neill BP, Iturria NJ, Link MJ, et al. A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases. Int J Radiat Oncol Biol Phys. 2003;55:1169–1176
  5. Rades D, Pluemer A, Veninga T, et al. A boost in addition to whole-brain radiotherapy improves patient outcome after resection of 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients. Cancer. 2007;110:1551–1559
  6. Gaspar LE, Scott C, Rotman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 1997;37:745–751
  7. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  8. Trotti A, Byhardt R, Stetz J, et al. Common toxicity criteria: Version 2.0. An improved reference for grading the acute effects of cancer treatment: Impact on radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47:13–47
  9. Bruner DW, Wasserman T. The impact on quality of life by radiation late effects. Int J Radiat Oncol Biol Phys. 1995;31:1353–1355
  10. Vogelbaum MA, Suh JH. Resectable brain metastases. J Clin Oncol. 2006;24:1289–1294
  11. Khuntia D, Brown P, Li J, et al. Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol. 2006;24:1295–1304

 Conflict of interest: none.

PII: S0360-3016(08)00927-9

doi: 10.1016/j.ijrobp.2008.05.035

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1077-1081 , 15 March 2009

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