International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 1 , Pages 255-260 , 1 September 2008

Effect of Pretreatment Anemia on Treatment Outcome of Concurrent Radiochemotherapy in Patients With Head and Neck Cancer

  • André Fortin, M.D., M.Sc.

      Affiliations

    • Department of Radiation Oncology, L'Hôtel-Dieu de Québec, Québec, Canada
    • Corresponding Author InformationReprint requests to: André Fortin, M.D., M.Sc., Department of Radiation Oncology, CHUQ, L'Hotel-Dieu de Québec, 11 Côte du Palais, Québec, Québec, Canada G1R 2J6. Tel: (418) 691-5264, Fax: (418) 691-5268
  • ,
  • Chang Shu Wang, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, L'Hôtel-Dieu de Québec, Québec, Canada
  • ,
  • Éric Vigneault, M.D., M.Sc.

      Affiliations

    • Department of Radiation Oncology, L'Hôtel-Dieu de Québec, Québec, Canada

Received 21 March 2008 ,Revised 26 April 2008 ,Accepted 30 April 2008.

References 

  1. Varlotto J, Stevenson MA. Anemia, tumor hypoxemia, and the cancer patient. Int J Radiat Oncol Biol Phys. 2005;63:25–36
  2. Harrison L, Shasha D, Shiaova L, et al. Prevalence of anemia in cancer patients undergoing radiation therapy. Semin Oncol. 2001;28:54–59
  3. Lee WR, Berkey B, Marcial V, et al. Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: A secondary analysis of RTOG 85–27. Int J Radiat Oncol Biol Phys. 1998;42:1069–1075
  4. Dubray B, Mosseri V, Brunin F, et al. Anemia is associated with lower local-regional control and survival after radiation therapy for head and neck cancer: A prospective study. Radiology. 1996;201:553–558
  5. van de Pol SM, Doornaert PA, de Bree R, et al. The significance of anemia in squamous cell head and neck cancer treated with surgery and postoperative radiotherapy. Oral Oncol. 2006;42:131–138
  6. Prosnitz RG, Yao B, Farrell CL, et al. Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 2005;61:1087–1095
  7. Izaks GJ, Westendorp RG, Knook DL. The definition of anemia in older persons. JAMA. 1999;281:1714–1717
  8. Christensen E. Multivariate survival analysis using Cox's regression model. Hepatology. 1987;7:1346–1358
  9. Denis F, Garaud P, Bardet E, et al. Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol. 2004;22:69–76
  10. Wu WC, Rathore SS, Wang Y, et al. Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med. 2001;345:1230–1236
  11. Zakai NA, Katz R, Hirsch C, et al. A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study. Arch Intern Med. 2005;165:2214–2220
  12. Chaves PH, Xue QL, Guralnik JM, et al. What constitutes normal hemoglobin concentration in community-dwelling disabled older women?. J Am Geriatr Soc. 2004;52:1811–1816
  13. Kikuchi M, Inagaki T, Shinagawa N. Five-year survival of older people with anemia: Variation with hemoglobin concentration. J Am Geriatr Soc. 2001;49:1226–1228
  14. Fyles AW, Milosevic M, Pintilie M, et al. Anemia, hypoxia and transfusion in patients with cervix cancer: a review. Radiother Oncol. 2000;57:13–19
  15. Machtay M, Pajak TF, Suntharalingam M, et al. Radiotherapy with or without erythropoietin for anemic patients with head and neck cancer: A randomized trial of the Radiation Therapy Oncology Group (RTOG 99-03). Int J Radiat Oncol Biol Phys. 2007;69:1008–1017
  16. Henke M, Laszig R, Rube C, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial. Lancet. 2003;362:1255–1260
  17. Rades D, Stoehr M, Kazic N, et al. Locally advanced stage IV squamous cell carcinoma of the head and neck: Impact of pre-radiotherapy hemoglobin level and interruptions during radiotherapy. Int J Radiat Oncol Biol Phys. 2008;70:1108–1114
  18. Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 1996;379:88–91
  19. Kinoshita M, Johnson DL, Shatney CH, et al. Cancer cells surviving hypoxia obtain hypoxia resistance and maintain anti-apoptotic potential under reoxygenation. Int J Cancer. 2001;91:322–326
  20. Vaupel P, Mayer A. Hypoxia and anemia: effects on tumor biology and treatment resistance. Transfus Clin Biol. 2005;12:5–10
  21. Overgaard J, Hansen HS, Specht L, et al. Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial. Lancet. 2003;362:933–940(Erratum in Lancet 2003;362:1588)
  22. Rosenthal DI, Lewin JS, Eisbruch A. Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer. J Clin Oncol. 2006;24:2636–2643

 Conflict of interest: none.

PII: S0360-3016(08)00934-6

doi: 10.1016/j.ijrobp.2008.04.079

International Journal of Radiation Oncology * Biology * Physics
Volume 72, Issue 1 , Pages 255-260 , 1 September 2008