International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1049-1054 , 15 March 2009

Analysis of Factors Associated With Radiation-Induced Bronchiolitis Obliterans Organizing Pneumonia Syndrome After Breast-Conserving Therapy

  • Norihisa Katayama, M.D.

      Affiliations

    • Department of Radiology, Okayama University Hospital, Okayama, Japan
    • Corresponding Author InformationReprint requests to: Norihisa Katayama, M.D., Department of Radiology, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. Tel: (+81) 86-235-7313; Fax: (+81) 86-235-7316
    • ,
  • Shuhei Sato, M.D., Ph.D.

      Affiliations

    • Department of Radiology, Okayama University Hospital, Okayama, Japan
    • ,
  • Kuniaki Katsui, M.D., Ph.D.

      Affiliations

    • Department of Radiology, Fukuyama City Hospital, Fukuyama, Japan
    • ,
  • Mitsuhiro Takemoto, M.D., Ph.D.

      Affiliations

    • Department of Radiology, Okayama University Hospital, Okayama, Japan
    • ,
  • Toshihide Tsuda, M.D., Ph.D.

      Affiliations

    • Department of Environmental Epidemiology, Graduate School of Environmental Science, Okayama University Graduate School, Okayama, Japan
    • ,
  • Atsushi Yoshida, M.D., Ph.D.

      Affiliations

    • Department of Radiology, Kure Kyosai Hospital, Kure, Japan
    • ,
  • Tsuneharu Morito, M.D.

      Affiliations

    • Department of Radiology, Okayama Saiseikai General Hospital, Okayama, Japan
    • ,
  • Tomio Nakagawa, M.D., Ph.D.

      Affiliations

    • Department of Radiology, NHO Fukuyama Medical Center, Fukuyama, Japan
    • ,
  • Akifumi Mizuta, M.D., Ph.D.

      Affiliations

    • Department of Radiology, Chugoku Central Hospital, Fukuyama, Japan
    • ,
  • Takahiro Waki, M.D.

      Affiliations

    • Department of Radiology, NHO Okayama Medical Center, Okayama, Japan
    • ,
  • Harutaka Niiya, M.D., Ph.D.

      Affiliations

    • Department of Radiology, NHO Okayama Medical Center, Okayama, Japan
    • ,
  • Susumu Kanazawa, M.D., Ph.D.

      Affiliations

    • Department of Radiology, Okayama University Hospital, Okayama, Japan

Received 4 April 2008 ,Revised 26 May 2008 ,Accepted 27 May 2008.

References 

  1. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005;366:2087–2106
  2. Crestani B, Valeyre D, Roden S, et al. Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. Am J Respir Crit Care Med. 1998;158:1929–1935
  3. Takigawa N, Segawa Y, Saeki T, et al. Bronchiolitis obliterans organizing pneumonia syndrome in breast-conserving therapy for early breast cancer: Radiation-induced lung toxicity. Int J Radiat Oncol Biol Phys. 2000;48:751–755
  4. Miwa S, Morita S, Suda T, et al. The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiotherapy for breast cancer. Sarcoidosis Vasc Diffuse Lung Dis. 2004;21:212–218
  5. Abratt RP, Morgan GW. Lung toxicity following chest irradiation in patients with lung cancer. Lung Cancer. 2002;35:103–109
  6. Logan PM. Thoracic manifestations of external beam radiotherapy. AJR Am J Roentgenol. 1998;171:569–577
  7. Epler GR, Colby TV, McLoud TC, et al. Bronchiolitis obliterans organizing pneumonia. N Engl J Med. 1985;312:152–158
  8. Fraser RS, Muller NL, Colman N, et al. Diagnosis of disease of the chest. 4th ed.. Philadelphia: WB Saunders; 1999;p. 2344–2348
  9. Majori M, Poletti V, Curti A, et al. Bronchoalveolar lavage in bronchiolitis obliterans organizing pneumonia primed by radiation therapy to the breast. J Allergy Clin Immunol. 2000;105:239–244
  10. Crestani B, Kambouchner M, Soler P, et al. Migratory bronchiolitis obliterans organizing pneumonia after unilateral radiation therapy for breast carcinoma. Eur Respir J. 1995;8:318–321
  11. Prakash UB. Radiation-induced injury in the “nonirradiated” lung. Eur Respir J. 1999;13:715–717
  12. Dorr W, Bertmann S, Herrmann T. Radiation induced lung reactions in breast cancer therapy. Modulating factors and consequential effects. Strahlenther Onkol. 2005;181:567–573
  13. Koc M, Polat P, Suma S. Effects of tamoxifen on pulmonary fibrosis after cobalt-60 radiotherapy in breast cancer patients. Radiother Oncol. 2002;64:171–175
  14. Huang EY, Wang CJ, Chen HC, et al. Multivariate analysis of pulmonary fibrosis after electron beam irradiation for postmastectomy chest wall and regional lymphatics: Evidence for non-dosimetric factors. Radiother Oncol. 2000;57:91–96
  15. Colletta AA, Wakefield LM, Howell FV, et al. Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. Br J Cancer. 1990;62:405–409
  16. Anscher MS, Peter WP, Reisenbichler H, et al. Trans-forming growth factor beta 1 as a predictor of lung and liver fibrosis after autologous bone marrow transplantation for advanced breast cancer. N Engl J Med. 1993;328:1592–1598
  17. Lind PA, Marks LB, Hardenbergh PH, et al. Technical factors associated with radiation pneumonitis after local +/- regional radiation therapy for breast cancer. Int J Radiat Oncol Biol Phys. 2002;52:137–143
  18. Allen AM, Prosnitz RG, Ten Haken RK, et al. Body mass index predicts the incidence of radiation pneumonitis in breast cancer patients. Cancer J. 2005;11:390–398
  19. Lind PA, Wennberg B, Gagliardi G, et al. ROC curves and evaluation of radiation-induced pulmonary toxicity in breast cancer. Int J Radiat Oncol Biol Phys. 2006;64:765–770
  20. Kahán Z, Csenki M, Varga Z, et al. The risk of early and late lung sequelae after conformal radiotherapy in breast cancer patients. Int J Radiat Oncol Biol Phys. 2007;68:673–681
  21. Gagliardi G, Bjohle J, Lax I, et al. Radiation pneumonitis after breast cancer irradiation: Analysis of the complication probability using the relative seriality model. Int J Radiat Oncol Biol Phys. 2000;46:373–381
  22. Lingos TI, Recht A, Vicini F, et al. Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 1991;21:355–360
  23. Fernando IN, Powles TJ, Ashley S, et al. An acute toxicity study on the effects of synchronous chemotherapy and radiotherapy in early stage breast cancer after conservative surgery. Clin Oncol. 1996;8:234–238
  24. Lind PA, Gagliardi G, Wennberg B, et al. A descriptive study of pulmonary complications after postoperative radiation therapy in node-positive stage II breast cancer. Acta Oncol. 1997;36:509–515

 Presented at the 50th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Boston, Massachusetts, September 21–25, 2008.

 Conflict of interest: none.

PII: S0360-3016(08)00963-2

doi: 10.1016/j.ijrobp.2008.05.050

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1049-1054 , 15 March 2009

Article Tools