International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1055-1060 , 15 March 2009

Outcomes After Breast Conservation Treatment With Radiation in Women With Prior Nonbreast Malignancy and Subsequent Invasive Breast Carcinoma

  • Deepika Nemani, B.S.

      Affiliations

    • Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA
  • ,
  • Neha Vapiwala, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA
    • Corresponding Author InformationReprint requests to: Neha Vapiwala, M.D., Department of Radiation Oncology, 2 Donner Building, 3400 Spruce Street, Hospital of University of Pennsylvania, Philadelphia, PA 19104. Tel: (215) 662-2337; Fax: (215) 349-5445
  • ,
  • Wei-Ting Hwang, Ph.D.

      Affiliations

    • Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA
  • ,
  • Lawrence J. Solin, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA

Received 30 March 2008 ,Revised 20 May 2008 ,Accepted 28 May 2008.

References 

  1. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–1241
  2. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005;366:2087–2106
  3. Schwartz GF, Veronesi U, Clough KB, et al. Proceedings of the consensus conference on breast conservation, Milan, Italy, April 28–May 1, 2005. Int J Radiat Oncol Biol Phys. 2006;65:1281–1288
  4. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–1232
  5. Fowble B, Hanlon A, Freedman G, et al. Second cancers after conservative surgery and radiation for Stages I–II breast cancer: Identifying a subset of women at increased risk. Int J Radiat Oncol Biol Phys. 2001;51:679–690
  6. Kirova YM, Gambotti L, De Rycke Y, et al. Risk of second malignancies after adjuvant radiotherapy for breast cancer: A large-scale, single-institution review. Int J Radiat Oncol Biol Phys. 2007;68:359–363
  7. Hill-Kayser CE, Harris EE, Hwang WT, et al. Twenty-year incidence and patterns of contralateral breast cancer after breast conservation treatment with radiation. Int J Radiat Oncol Biol Phys. 2006;66:1313–1319
  8. Yadav BS, Sharma SC, Patel FD, et al. Second primary in the contralateral breast after treatment of breast cancer. Radiother Oncol. 2008;86:171–176
  9. Santiago RJ, Harris EE, Qin L, et al. Similar long-term results of breast-conservation treatment for Stage I and II invasive lobular carcinoma compared with invasive ductal carcinoma of the breast: The University of Pennsylvania experience. Cancer. 2005;103:2447–2454
  10. Santiago RJ, Wu L, Harris E, et al. Fifteen-year results of breast-conserving surgery and definitive irradiation for Stage I and II breast carcinoma: The University of Pennsylvania experience. Int J Radiat Oncol Biol Phys. 2004;58:233–240
  11. Fowble BL, Solin LJ, Schultz DJ, et al. Ten year results of conservative surgery and irradiation for stage I and II breast cancer. Int J Radiat Oncol Biol Phys. 1991;21:269–277
  12. Fowble B, Solin LJ, Schultz DJ. Conservative surgery and radiation for early breast cancer. In:  Fowble B,  Goodman RL,  Glick JH editor. Breast cancer treatment: A comprehensive guide to management. St. Louis, MO: Mosby Year Book; 1991;p. 105–149
  13. In:  Fleming ID,  Cooper JS,  Henson DE, et al. editor. AJCC Cancer Staging Manual. (ed 5). Philadelphia, PA: Lippincott-Raven; 1997;p. 171–180
  14. Social Security Death Index (SSDI) Interactive Search. RootsWeb. Available at: http://ssdi.rootsweb.ancestry.com/cgi-bin/ssdi.cgi. Accessed March 5, 2008.
  15. Kaplan EL MP. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  16. Greenwood M. The errors of sampling the survivorship tables. Rep Public Health Stat Subjects. 1926;33:1–26
  17. Touboul E, Buffat L, Belkacemi Y, et al. Local recurrences and distant metastases after breast-conserving surgery and radiation therapy for early breast cancer. Int J Radiat Oncol Biol Phys. 1999;43:25–38
  18. Doyle T, Schultz DJ, Peters C, et al. Long-term results of local recurrence after breast conservation treatment for invasive breast cancer. Int J Radiat Oncol Biol Phys. 2001;51:74–80
  19. Komoike Y, Akiyama F, Iino Y, et al. Ipsilateral breast tumor recurrence (IBTR) after breast-conserving treatment for early breast cancer: Risk factors and impact on distant metastases. Cancer. 2006;106:35–41
  20. Morrow M, Strom EA, Bassett LW, et al. Standard for breast conservation therapy in the management of invasive breast carcinoma. CA Cancer J Clin. 2002;52:277–300
  21. Fowble B, Hanlon A, Freedman G, et al. Second cancers after conservative surgery and radiation for stages I–II breast cancer: Identifying a subset of women at increased risk. Int J Radiat Oncol Biol Phys. 2001;51:679–690
  22. Galper S, Gelman R, Recht A, et al. Second nonbreast malignancies after conservative surgery and radiation therapy for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2002;52:406–414

 Presented in part at the First Annual Breast Cancer Symposium of the American Society of Clinical Oncology (ASCO), September 8, 2007, San Francisco, CA.

 Supported in part by a grant from The Breast Cancer Research Foundation.

 Conflict of interest: none.

PII: S0360-3016(08)00964-4

doi: 10.1016/j.ijrobp.2008.05.049

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1055-1060 , 15 March 2009