International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 2 , Pages 325-326 , 1 February 2009

Predicting Pathologic Stage, Nomograms, and Clinical Judgment: Don't Miss the Forest for the Trees!

  • Mack Roach III, M.D., F.A.C.R.

      Affiliations

    • Professor and Chair Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
    • Corresponding Author InformationReprint requests to: Mack Roach III, M.D., Department of Radiation Oncology, University of California San Francisco Comprehensive Cancer Center, Suite 1031-H, 1600 Divisadero Street, San Francisco, CA. Tel: (415) 353–7175; Fax: (415) 353–9883

Received 23 May 2008 ,Accepted 23 May 2008.

References 

  1. Roach M. Equations for predicting the pathologic stage of men with localized prostate cancer using the preoperative prostate specific antigen (PSA) and Gleason score. J Urol. 1993;150:1923–1924
  2. Seaward SA, Weinberg V, Lewis P, et al. Improved freedom from PSA failure with whole pelvic irradiation for high-risk prostate cancer. Int J Radiat Oncol Biol Phys. 1998;42:1055–1062
  3. Roach M, DeSilvio M, Lawton C, et al. Phase III trial comparing whole-pelvic versus prostate-only radiotherapy and neoadjuvant versus adjuvant combined androgen suppression: Radiation Therapy Oncology Group 9413. J Clin Oncol. 2003;21:1904–1911
  4. Nguyen PL, D'Amico AV. Targeting pelvic lymph nodes in men with intermediate- and high-risk prostate cancer despite two negative randomized trials. J Clin Oncol. 2008;26:2055–2056author reply 2056–2057
  5. Heidenreich A, Varga Z, Von Knobloch R. Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: High incidence of lymph node metastasis. J Urol. 2002;167:1681–1686
  6. Briganti A, Chun FK, Salonia A, et al. Critical assessment of ideal nodal yield at pelvic lymphadenectomy to accurately diagnose prostate cancer nodal metastasis in patients undergoing radical retropubic prostatectomy. Urology. 2007;69:147–151
  7. Pagliarulo V, Hawes D, Brands FH, et al. Detection of occult lymph node metastases in locally advanced node-negative prostate cancer. J Clin Oncol. 2006;24:2735–2742
  8. Ferrari AC, Stone NN, Kurek R, et al. Molecular load of pathologically occult metastases in pelvic lymph nodes is an independent prognostic marker of biochemical failure after localized prostate cancer treatment. J Clin Oncol. 2006;24:3081–3088
  9. Shariat SF, Kattan MW, Erdamar S, et al. Detection of clinically significant, occult prostate cancer metastases in lymph nodes using a splice variant-specific rt-PCR assay for human glandular kallikrein. J Clin Oncol. 2003;21:1223–1231
  10. Miyake H, Hara I, Kurahashi T, et al. Quantitative detection of micrometastases in pelvic lymph nodes in patients with clinically localized prostate cancer by real-time reverse transcriptase-PCR. Clin Cancer Res. 2007;13:1192–1197

 Conflict of interest: none.

PII: S0360-3016(08)02458-9

doi: 10.1016/j.ijrobp.2008.05.056

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 2 , Pages 325-326 , 1 February 2009

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