International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1069-1076 , 15 March 2009

Motexafin Gadolinium Combined With Prompt Whole Brain Radiotherapy Prolongs Time to Neurologic Progression in Non–Small-Cell Lung Cancer Patients With Brain Metastases: Results of a Phase III Trial

  • Minesh P. Mehta, M.D.

      Affiliations

    • Department of Human Oncology, University of Wisconsin, Madison, WI
    • Corresponding Author InformationReprint requests to: Minesh P. Mehta, M.D., Department of Human Oncology, Radiation Oncology, University of Wisconsin–Madison, K4/B100, 600 Highland Ave., Madison, WI 53792. Tel: (608) 263-8500; Fax: (608) 263-9167
    • ,
  • William R. Shapiro, M.D.

      Affiliations

    • Barrow Neurological Institute, Phoenix, AZ
    • ,
  • See C. Phan, M.D.

      Affiliations

    • Clinical Development, Pharmacyclics, Sunnyvale, CA
    • ,
  • Radj Gervais, M.D.

      Affiliations

    • Centre François Baclesse, Caen, France
    • ,
  • Christian Carrie, M.D.

      Affiliations

    • Centre Léon-Bérard, Lyon, France
    • ,
  • Pierre Chabot, M.D.

      Affiliations

    • Hôpital Maisonneuve-Rosemont, Montreal, QB, Canada
    • ,
  • Roy A. Patchell, M.D.

      Affiliations

    • University of Kentucky, Lexington, KY
    • ,
  • Michael J. Glantz, M.D.

      Affiliations

    • University of Massachusetts, Hinsdale, MA
    • ,
  • Lawrence Recht, M.D.

      Affiliations

    • Stanford University, Palo Alto, CA
    • ,
  • Corey Langer, M.D.

      Affiliations

    • Fox Chase Cancer Center, Philadelphia, PA
    • ,
  • Ranjan K. Sur, M.D., Ph.D.

      Affiliations

    • Juravinski Cancer Centre at Hamilton Regional Cancer Centre, Hamilton, ON, Canada
    • ,
  • Wilson H. Roa, M.D.

      Affiliations

    • Cross Cancer Institute, Edmonton, AB, Canada
    • ,
  • Marc A. Mahe, M.D.

      Affiliations

    • Centre René Gauducheau, Nantes-St. Herblain, France
    • ,
  • Andre Fortin, M.D.

      Affiliations

    • Hotel-Dieu de Québec, Québec, QB, Canada
    • ,
  • Carsten Nieder, M.D.

      Affiliations

    • Klinikum rechts der Isar der Technischen Universität Műnchen, Munich, Germany
    • ,
  • Christina A. Meyers, Ph.D.

      Affiliations

    • University of Texas M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Jennifer A. Smith, Ph.D.

      Affiliations

    • Clinical Development, Pharmacyclics, Sunnyvale, CA
    • ,
  • Richard A. Miller, M.D.

      Affiliations

    • Clinical Development, Pharmacyclics, Sunnyvale, CA
    • ,
  • Markus F. Renschler, M.D.

      Affiliations

    • Clinical Development, Pharmacyclics, Sunnyvale, CA

Received 25 March 2008 ,Revised 19 May 2008 ,Accepted 20 May 2008.

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 Supported by Pharmacyclics, Inc., Sunnyvale, CA.

 Conflict of interest: the study was sponsored by Pharmacyclics, Inc.; the following authors are (or were during the study period) employees and shareholders of Pharmacyclics, Inc.: See-Chun Phan, M.D., Jennifer Smith, Ph.D., Richard Miller, M.D., and Markus Renschler, M.D.

PII: S0360-3016(08)02953-2

doi: 10.1016/j.ijrobp.2008.05.068

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1069-1076 , 15 March 2009

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