International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1352-1357 , 1 April 2009

Radiographic and Histopathologic Observations After Combined EGFR Inhibition and Hypofractionated Stereotactic Radiosurgery in Patients With Recurrent Malignant Gliomas

  • Amanda L. Schwer, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Denver, Aurora, CO
    • ,
  • Brian D. Kavanagh, M.D., M.P.H.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Denver, Aurora, CO
    • ,
  • Robert McCammon, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Denver, Aurora, CO
    • ,
  • Laurie E. Gaspar, M.D., M.B.A.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Denver, Aurora, CO
    • ,
  • B.K. Kleinschmidt-De Masters, M.D.

      Affiliations

    • Department of Pathology, University of Colorado Denver, Aurora, CO
    • ,
  • Kelly Stuhr, M.S.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Denver, Aurora, CO
    • ,
  • Changhu Chen, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado Denver, Aurora, CO
    • Corresponding Author InformationReprint requests to: Changhu Chen, M.D., Department of Radiation Oncology, University of Colorado Denver, 1665 N. Ursula St., Suite 1032, Mail Stop F-706, P.O. Box 6510, Aurora, CO 80045-0508. Tel: (720) 848-0116; Fax: (720) 848-0222

Received 22 March 2008 ,Revised 5 May 2008 ,Accepted 23 June 2008.

References 

  1. Schwer AL, Damek DM, Kavanagh BD, et al. A phase I dose escalation study of fractionated stereotactic radiosurgery (SRS) in combination with gefitinib in patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2008;70:993–1001
  2. Shinoda J, Yano H, Ando H, et al. Radiological response and histological changes in malignant astrocytic tumors after stereotactic radiosurgery. Brain Tumor Pathol. 2003;19:83–92
  3. Kondziolka D, Flickinger JC, Bissonetter DJ, et al. Survival benefit of stereotactic radiosurgery for patients with malignant glial neoplasms. Neurosurgery. 1997;41:776–783
  4. Hall WA, Djalilian HR, Sperduto PW, et al. Stereotactic radiosurgery for recurrent malignant gliomas. J Clin Oncol. 1995;13:1642–1648
  5. Forsyth PA, Kelly PJ, Cascino TL, et al. Radiation necrosis or glioma recurrence: Is computer assisted stereotactic biopsy useful?. J Neurosurg. 1995;82:436–444
  6. McGirt MJ, Bulsara KR, Cummings TJ, et al. Prognostic value of magnetic resonance imaging-guided stereotactic biopsy in the evaluation of recurrent malignant astrocytoma compared with a lesion due to radiation effect. J Neurosurg. 2003;98:14–20
  7. Zamorano L, Katanick D, Dujovny M, et al. Tumor recurrence vs. radionecrosis: An indication for multitrajectory serial stereotactic biopsies. Acta Neurochir Suppl. 1989;46:90–93
  8. Graves EE, Nelson SJ, Vigneron DB, et al. Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. Am J Neuroradiol. 2001;22:598–599
  9. Kimura T, Sako K, Tanaka K, et al. Evaluation of the response of metastatic brain tumors to stereotactic radiosurgery by proton magnetic resonance spectroscopy, 201T1C1 single-photon emission computerized tomography, and gadolinium-enhanced magnetic resonance imaging. J Neurosurg. 2004;100:835–841
  10. Rabinov JD, Lee PL, Barker FG, et al. In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: Initial experience. Radiology. 2002;225:871–879
  11. Hein PA, Eskey CJ, Dunn JF, et al. Diffusion-weighted imaging in the follow-up of treated high-grade gliomas: Tumor recurrence versus radiation injury. Am J Neuroradiol. 2004;25:201–209
  12. Batchelor TT, Sorenson AG, diTomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007;11:83–95
  13. Belda-Iniesta C, de Castro Carpeno J, Casado Saenz E, et al. Long term responses with cetuximab therapy in glioblastoma multiforme. Cancer Biol Ther. 2006;5:912–914
  14. Pope WB, Lai A, Nghiemphu P, et al. MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology. 2006;66:1258–1260

 Preliminary results presented at the 2007 American Society for Therapeutic Radiology and Oncology Annual Meeting, October 28 to November 1, Los Angeles, CA.

 Conflict of interest: none.

PII: S0360-3016(08)02954-4

doi: 10.1016/j.ijrobp.2008.06.1919

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1352-1357 , 1 April 2009

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