International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1319-1325 , 1 April 2009

No Detectable Hypoxia in Malignant Salivary Gland Tumors: Preliminary Results

  • Karien I.E.M. Wijffels, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Deventer Hospital, Deventer, The Netherlands
    • ,
  • Ilse J. Hoogsteen, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Jasper Lok, B.Sc.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Paulus F.J.W. Rijken, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Henri A.M. Marres, M.D., Ph.D.

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Peter C.M. de Wilde, M.D., Ph.D.

      Affiliations

    • Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Albert J. van der Kogel, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Johannes H.A.M. Kaanders, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Corresponding Author InformationReprint requests to: J. H. A. M. Kaanders, M.D., Ph.D., Department of Radiation Oncology, 874, Radboud University Nijmegen Medical Centre, P.O. Box 9101, Nijmegen 6500 HB The Netherlands. Tel: (31) 243614515; Fax: (31) 243610792

Received 31 March 2008 ,Revised 23 June 2008 ,Accepted 23 June 2008.

References 

  1. Harris AL. Hypoxia—A key regulatory factor in tumour growth. Nat Rev Cancer. 2002;2:38–47
  2. Le QT, Denko NC, Giaccia AJ. Hypoxic gene expression and metastasis. Cancer Metastasis Rev. 2004;23:293–310
  3. Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 1996;379:88–91
  4. Hoogsteen IJ, Marres HA, van der Kogel AJ, et al. The hypoxic tumour microenvironment, patient selection and hypoxia-modifying treatments. Clin Oncol (R Coll Radiol). 2007;19:385–396
  5. Vaupel P, Mayer A, Hockel M. Tumor hypoxia and malignant progression. Methods Enzymol. 2004;381:335–354
  6. Vaupel P, Mayer A. Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev. 2007;26:225–239
  7. Kaanders JH, Bussink J, van der Kogel AJ. Clinical studies of hypoxia modification in radiotherapy. Semin Radiat Oncol. 2004;14:233–240
  8. Schlingemann RO, Dingjan GM, Emeis JJ, et al. Monoclonal antibody PAL-E specific for endothelium. Lab Invest. 1985;52:71–76
  9. Rijken PF, Bernsen HJ, van der Kogel AJ. Application of an image analysis system to the quantitation of tumor perfusion and vascularity in human glioma xenografts. Microvasc Res. 1995;50:141–153
  10. Jakobsson PA, Eneroth CM. Variations in radiosensitivity of various types of malignant salivary-gland tumour. Acta Otolaryngol Suppl. 1969;263:186–188
  11. Hara S, Nakashiro K, Klosek SK, et al. Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells. Oral Oncol. 2006;42:593–598
  12. Lindsley KL, Cho P, Stelzer KJ, et al. Clinical trials of neutron radiotherapy in the United States. Bull Cancer Radiother. 1996;83(Suppl.):78s–86s
  13. Wambersie A, Hendry J, Gueulette J, et al. Radiobiological rationale and patient selection for high-LET radiation in cancer therapy. Radiother Oncol. 2004;73(Suppl. 2):S1–S14
  14. Kleiter MM, Thrall DE, Malarkey DE, et al. A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker. Int J Radiat Oncol Biol Phys. 2006;64:592–602
  15. Kaanders JH, Wijffels KI, Marres HA, et al. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Res. 2002;62:7066–7074
  16. Hoskin PJ, Sibtain A, Daley FM, et al. The immunohistochemical assessment of hypoxia, vascularity and proliferation in bladder carcinoma. Radiother Oncol. 2004;72:159–168
  17. Arcasoy MO, Amin K, Karayal AF, et al. Functional significance of erythropoietin receptor expression in breast cancer. Lab Invest. 2002;82:911–918
  18. Rijken PF, Peters JP, Van der Kogel AJ. Quantitative analysis of varying profiles of hypoxia in relation to functional vessels in different human glioma xenograft lines. Radiat Res. 2002;157:626–632
  19. Yuan H, Schroeder T, Bowsher JE, et al. Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med. 2006;47:989–998
  20. Lal A, Peters H, St Croix B, et al. Transcriptional response to hypoxia in human tumors. J Natl Cancer Inst. 2001;93:1337–1343
  21. Zhang JZ, Behrooz A, Ismail-Beigi F. Regulation of glucose transport by hypoxia. Am J Kidney Dis. 1999;34:189–202
  22. Sly WS, Hu PY. Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995;64:375–401
  23. Ishibashi H, Shiratuchi T, Nakagawa K, et al. Hypoxia-induced angiogenesis of cultured human salivary gland carcinoma cells enhances vascular endothelial growth factor production and basic fibroblast growth factor release. Oral Oncol. 2001;37:77–83
  24. Wijffels KI, Marres HA, Peters JP, et al. Tumour cell proliferation under hypoxic conditions in human head and neck squamous cell carcinomas. Oral Oncol. 2008;44:335–344
  25. Hoogsteen IJ, Marres HA, Wijffels KI, et al. Colocalization of carbonic anhydrase 9 expression and cell proliferation in human head and neck squamous cell carcinoma. Clin Cancer Res. 2005;11:97–106
  26. Raleigh JA, Zeman EM, Calkins DP, et al. Distribution of hypoxia and proliferation associated markers in spontaneous canine tumors. Acta Oncol. 1995;34:345–349
  27. Wykoff CC, Beasley NJ, Watson PH, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res. 2000;60:7075–7083
  28. Ang KK, Berkey BA, Tu X, et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res. 2002;62:7350–7356
  29. Vered M, Braunstein E, Buchner A. Immunohistochemical study of epidermal growth factor receptor in adenoid cystic carcinoma of salivary gland origin. Head Neck. 2002;24:632–636
  30. Agulnik M, Cohen EW, Cohen RB, et al. Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands. J Clin Oncol. 2007;25:3978–3984
  31. Psyrri A, Yu Z, Weinberger PM, et al. Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res. 2005;11:5856–5862
  32. Lo HW, Xia W, Wei Y, et al. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res. 2005;65:338–348
  33. Lin SY, Makino K, Xia W, et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol. 2001;3:802–808
  34. Wang SC, Nakajima Y, Yu YL, et al. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol. 2006;8:1359–1368
  35. Dittmann K, Mayer C, Kehlbach R, et al. The radioprotector Bowman-Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport. Radiother Oncol. 2008;86:375–382

 Supported by Grant KUN 98-1814 from the Dutch Cancer Society.

 Conflict of interest: none.

PII: S0360-3016(08)02976-3

doi: 10.1016/j.ijrobp.2008.06.1927

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1319-1325 , 1 April 2009

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