International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 1 , Pages 67-72 , 1 May 2009

Does Adjuvant Radiotherapy Suppress Liver Regeneration After Partial Hepatectomy?

  • Jin-Hwa Choi, M.D.

      Affiliations

    • Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Kyubo Kim, M.D.

      Affiliations

    • Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Eui Kyu Chie, M.D.

      Affiliations

    • Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    • Corresponding Author InformationReprint requests to: Eui Kyu Chie, M.D., Department of Radiation Oncology, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea. Tel: +82-2-2072-3705; Fax: +82-2-765-3317
    • ,
  • Jin-Young Jang, M.D.

      Affiliations

    • Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Sun Whe Kim, M.D.

      Affiliations

    • Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Do-Youn Oh, M.D.

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Seock-Ah Im, M.D.

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Tae-You Kim, M.D.

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Yung-Jue Bang, M.D.

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Sung W. Ha, M.D.

      Affiliations

    • Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    • Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea

Received 30 April 2008 ,Revised 11 June 2008 ,Accepted 12 June 2008.

References 

  1. Gores GJ. Cholangiocarcinoma: Current concepts and insights. Hepatology. 2003;37:961–969
  2. Shaib Y, El-Serag HB. The epidemiology of cholangiocarcinoma. Semin Liver Dis. 2004;24:115–125
  3. Jarnagin WR, Shoup M. Surgical management of cholangiocarcinoma. Semin Liver Dis. 2004;24:189–199
  4. Fausto N. Liver regeneration. J Hepatol. 2000;32(Suppl 1):19–31
  5. Mangnall D, Bird NC, Majeed AW. The molecular physiology of liver regeneration following partial hepatectomy. Liver Int. 2003;23:124–138
  6. Michalopoulos GK, DeFrances MC. Liver regeneration. Science. 1997;276:60–66
  7. Miyagawa S, Kawasaki S, Noike T, et al. Liver regeneration after extended right hemihepatectomy in patients with hilar or diffuse bile duct carcinoma. Hepato-gastroenterology. 1999;46:364–368
  8. Nagino M, Ando M, Kamiya J, et al. Liver regeneration after major hepatectomy for biliary cancer. Br J Surg. 2001;88:1084–1091
  9. Nagasue N, Yukaya H, Ogawa Y, Kohno H, Nakamura T. Human liver regeneration after major hepatic resection. A study of normal liver and livers with chronic hepatitis and cirrhosis. Ann Surg. 1987;206:30–39
  10. Ogasawara K, Une Y, Nakajima Y, Uchino J. The significance of measuring liver volume using computed tomographic images before and after hepatectomy. Surg Today. 1995;25:43–48
  11. Shimada M, Matsumata T, Maeda T, et al. Hepatic regeneration following right lobectomy: Estimation of regenerative capacity. Surg Today. 1994;24:44–48
  12. Yamanaka N, Okamoto E, Kawamura E, et al. Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function. Hepatology. 1993;18:79–85
  13. Mosteller RD. Simplified calculation of body-surface area. N Engl J Med. 1987;317:1098
  14. Pomfret EA, Pomposelli JJ, Gordon FD, et al. Liver regeneration and surgical outcome in donors of right-lobe liver grafts. Transplantation. 2003;76:5–10
  15. Gragg RL, Humphrey RM, Thames HD, Meyn RE. The response of Chinese hamster ovary cells to fast neutron radiotherapy beams. III. Variation in biological effectiveness with position in the cell cycle. Radiat Res. 1978;76:283–291
  16. Leeper DB, Schneiderman MH, Dewey WC. Radiation-induced cycle delay in synchronized Chinese hamster cells: Comparison between DNA synthesis and division. Radiat Res. 1973;53:326–337
  17. Ngo FQ, Blakely EA, Tobias CA, Chang PY, Lommel L. Sequential exposures of mammalian cells to low- and high-LET radiations. II. As a function of cell cycle stages. Radiat Res. 1988;115:54–69
  18. Kil WJ, Kim DY, Kim TH, et al. Geometric shifting of the porta hepatis during posthepatectomy radiotherapy for biliary tract cancer. Int J Radiat Oncol Biol Phys. 2006;66:212–216
  19. Pan CC, Krishnan U, Normolle D, Lawrence TS. Ten Haken RK. Liver regeneration in patients with intrahepatic malignancies treated with focal liver radiation therapy. [Abstract] Int J Radiat Oncol Biol Phys. 2007;69(Suppl):S81
  20. Nagasue N, Kobayashi M, Iwaki A, et al. Effect of 5-fluorouracil on liver regeneration and metabolism after partial hepatectomy in the rat. Cancer. 1978;41:435–443
  21. McDermott WJ, Greenberger N, Isselbacher K, et al. Major hepatic resection: Diagnostic techniques and metabolic problems. Surgery. 1963;54:56–66
  22. Pack GT, Islami AH, Hubbard JC, Brasfield RD. Regeneration of human liver after major hepatectomy. Surgery. 1962;52:617–623
  23. Millikan KW, Silverstein JC, Timmerman G, Economou SG. Fractionated irradiation on the regenerated rat liver. J Surg Res. 1995;59:229–235
  24. Cardoso JE, Trivillin VA, Heber EM, et al. Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases. Int J Radiat Biol. 2007;83:699–706

 J.H. Choi and K. Kim contributed equally to this study.

 Presented at the 49th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Los Angeles, CA, Oct 27–Nov 1, 2007.

 Conflict of interest: none.

PII: S0360-3016(08)03051-4

doi: 10.1016/j.ijrobp.2008.06.1941

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 1 , Pages 67-72 , 1 May 2009

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