International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 1 , Pages 47-54 , 1 May 2009

Dose–Response Relationship for Image-Guided Stereotactic Body Radiotherapy of Pulmonary Tumors: Relevance of 4D Dose Calculation

  • Matthias Guckenberger, M.D.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany
    • Corresponding Author InformationReprint requests to: Dr. Matthias Guckenberger, Department of Radiation Oncology, University of Wuerzburg, Josef-Schneider-St. 11, 97080 Wuerzburg, Germany. Tel: (+49) 931-201-28884; Fax: (+49) 931-201-28221
  • ,
  • Joern Wulf, M.D.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany
    • Department of Radiooncology, Lindenhofspital, Bern, Switzerland
  • ,
  • Gerd Mueller, M.D.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany
  • ,
  • Thomas Krieger, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany
  • ,
  • Kurt Baier, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany
  • ,
  • Manuela Gabor, M.S.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany
  • ,
  • Anne Richter, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany
  • ,
  • Juergen Wilbert, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany
  • ,
  • Michael Flentje, M.D.

      Affiliations

    • Department of Radiation Oncology, Julius-Maximilians University, Wuerzburg, Germany

Received 3 April 2008 ,Revised 11 June 2008 ,Accepted 12 June 2008.

References 

  1. McGarry RC, Papiez L, Williams M, et al. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: Phase I study. Int J Radiat Oncol Biol Phys. 2005;63:1010–1015
  2. Xia T, Li H, Sun Q, et al. Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable Stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2006;66:117–125
  3. Zimmermann FB, Geinitz H, Schill S, et al. Stereotactic hypofractionated radiation therapy for stage I non-small cell lung cancer. Lung Cancer. 2005;48:107–114
  4. Wulf J, Haedinger U, Oppitz U, et al. Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: A noninvasive treatment approach in medically inoperable patients. Int J Radiat Oncol Biol Phys. 2004;60:186–196
  5. Nyman J, Johansson KA, Hulten U. Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer—Mature results for medically inoperable patients. Lung Cancer. 2006;51:97–103
  6. Onishi H, Kuriyama K, Komiyama T, et al. Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: Patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner. Lung Cancer. 2004;45:45–55
  7. Uematsu M, Shioda A, Suda A, et al. Computed tomography-guided frameless stereotactic radiotherapy for stage I non-small cell lung cancer: A 5-year experience. Int J Radiat Oncol Biol Phys. 2001;51:666–670
  8. Beitler JJ, Badine EA, El-Sayah D, et al. Stereotactic body radiation therapy for nonmetastatic lung cancer: An analysis of 75 patients treated over 5 years. Int J Radiat Oncol Biol Phys. 2006;65:100–106
  9. Lee SW, Choi EK, Park HJ, et al. Stereotactic body frame based fractionated radiosurgery on consecutive days for primary or metastatic tumors in the lung. Lung Cancer. 2003;40:309–315
  10. Lagerwaard FJ, Haasbeek CJ, Smit EF, et al. Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2008;70:685–692
  11. Hof H, Muenter M, Oetzel D, et al. Stereotactic single-dose radiotherapy (radiosurgery) of early stage nonsmall-cell lung cancer (NSCLC). Cancer. 2007;110:148–155
  12. Keall PJ, Mageras GS, Balter JM, et al. The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med Phys. 2006;33:3874–3900
  13. Haedinger U, Krieger T, Flentje M, et al. Influence of calculation model on dose distribution in stereotactic radiotherapy for pulmonary targets. Int J Radiat Oncol Biol Phys. 2005;61:239–249
  14. Wulf J, Hadinger U, Oppitz U, et al. Impact of target reproducibility on tumor dose in stereotactic radiotherapy of targets in the lung and liver. Radiother Oncol. 2003;66:141–150
  15. Guckenberger M, Meyer J, Wilbert J, et al. Cone-beam CT based image-guidance for extracranial stereotactic radiotherapy of intrapulmonary tumors. Acta Oncol. 2006;45:897–906
  16. Guckenberger M, Wilbert J, Meyer J, et al. Is a single respiratory correlated 4D-CT study Sufficient for Evaluation of Breathing Motion?. Int J Radiat Oncol Biol Phys. 2007;67:1352–1359
  17. Guckenberger M, Wilbert J, Krieger T, et al. Four-dimensional treatment planning for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2007;69:276–285
  18. Guckenberger M, Heilman K, Wulf J, et al. Pulmonary injury and tumor response after stereotactic body radiotherapy (SBRT): Results of a serial follow-up CT study. Radiother Oncol. 2007;85:435–442
  19. Kallman P, Agren A, Brahme A. Tumour and normal tissue responses to fractionated non-uniform dose delivery. Int J Radiat Biol. 1992;62:249–262
  20. Krieger T, Sauer OA. Monte Carlo- versus pencil-beam-/collapsed-cone-dose calculation in a heterogeneous multi-layer phantom. Phys Med Biol. 2005;50:859–868
  21. Purdie TG, Bissonnette JP, Franks K, et al. Cone-beam computed tomography for on-line image guidance of lung stereotactic radiotherapy: Localization, verification, and intrafraction tumor position. Int J Radiat Oncol Biol Phys. 2007;68:243–252
  22. Guckenberger M, Meyer J, Wilbert J, et al. Intra-fractional uncertainties in cone-beam CT based image-guided radiotherapy (IGRT) of pulmonary tumors. Radiother Oncol. 2007;83:57–64
  23. Uematsu M, Shioda A, Suda A, et al. Intrafractional tumor position stability during computed tomography (CT)-guided frameless stereotactic radiation therapy for lung or liver cancers with a fusion of CT and linear accelerator (FOCAL) unit. Int J Radiat Oncol Biol Phys. 2000;48:443–448
  24. Korreman SS, Juhler-Nottrup T, Boyer AL. Respiratory gated beam delivery cannot facilitate margin reduction, unless combined with respiratory correlated image guidance. Radiother Oncol. 2008;86:61–68
  25. van der Geld YG, Lagerwaard FJ, van Sornsen de Koste JR, et al. Reproducibility of target volumes generated using uncoached 4-dimensional CT scans for peripheral lung cancer. Radiat Oncol. 2006;1:43
  26. Haasbeek CJ, Lagerwaard FJ, Cuijpers JP, et al. Is adaptive treatment planning required for stereotactic radiotherapy of stage I non-small-cell lung cancer?. Int J Radiat Oncol Biol Phys. 2007;67:1370–1374
  27. Wulf J, Baier K, Mueller G, et al. Dose-response in stereotactic irradiation of lung tumors. Radiother Oncol. 2005;77:83–87
  28. Willner J, Baier K, Caragiani E, et al. Dose, volume, and tumor control prediction in primary radiotherapy of non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2002;52:382–389
  29. Martel MK, Ten Haken RK, Hazuka MB, et al. Estimation of tumor control probability model parameters from 3-D dose distributions of non-small cell lung cancer patients. Lung Cancer. 1999;24:31–37
  30. Onishi H, Shirato H, Nagata Y, et al. Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study. J Thorac Oncol. 2007;2:S94–S100
  31. Onimaru R, Fujino M, Yamazaki K, et al. Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy. Int J Radiat Oncol Biol Phys. 2008;70:374–381
  32. Casamassima F, Masi L, Bonucci I, et al. Relevance of biologically equivalent dose values in outcome evaluation of stereotactic radiotherapy for lung nodules. Int J Radiat Oncol Biol Phys. 2008;71:145–151
  33. Zimmermann FB, Geinitz H, Schill S, et al. Stereotactic hypofractionated radiotherapy in stage I (T1-2 N0 M0) non-small-cell lung cancer (NSCLC). Acta Oncol. 2006;45:796–801
  34. Ohta Y, Oda M, Wu J, et al. Can tumor size be a guide for limited surgical intervention in patients with peripheral non-small cell lung cancer? Assessment from the point of view of nodal micrometastasis. J Thorac Cardiovasc Surg. 2001;122:900–906
  35. Viney RC, Boyer MJ, King MT, et al. Randomized controlled trial of the role of positron emission tomography in the management of stage I and II non-small-cell lung cancer. J Clin Oncol. 2004;22:2357–2362

 Conflict of interest: none.

PII: S0360-3016(08)03053-8

doi: 10.1016/j.ijrobp.2008.06.1939

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 1 , Pages 47-54 , 1 May 2009