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Volume 73, Issue 5 , Pages 1383-1390 , 1 April 2009

The Effect of Radiation Dose and Chemotherapy on Overall Survival in 237 Patients With Stage III Non–Small-Cell Lung Cancer

Li Wang, M.D. Ph.D.
- Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI
- Department of Radiation Oncology, Cancer Center, Fudan University, Shanghai, China
Candace R. Correa, M.D.
- Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI
Lujun Zhao, M.D. Ph.D.
- Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI
James Hayman, M.D.
- Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI
Gregory P. Kalemkerian, M.D.
- Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI
Susan Lyons, M.D. Ph.D.
- Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI
Kemp Cease, M.D.
- Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI
Dean Brenner, M.D.
- Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI
Feng-Ming Kong, M.D. Ph.D.
- Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI
- Department of Radiation Oncology, Veterans Administration Health Center, Ann Arbor, MI
- Address reprint requests to: Feng-Ming (Spring) Kong, M.D., Ph.D., University of Michigan, Department of Radiation Oncology, UH-B2C490, Box 0010, 1500 E. Medical Center Dr., Ann Arbor, MI 48109. Tel: (734) 936-7810; Fax: (734) 763-7370

Received 28 March 2008 ,Revised 29 April 2008 ,Accepted 9 June 2008.

Overall survival. (a) Overall survival of the entire study group. (b) Overall survival curves by weight loss (<5% vs. ≥5%) with a significant difference in survival between the two groups (log-rank te

Overall survival. (a) Overall survival of the entire study group. (b) Overall survival curves by weight loss (<5% vs. ≥5%) with a significant difference in survival between the two groups (log-rank test, p = 0.0001).
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Chemotherapy and overall survival. (a) A significant difference in overall survival between radiation alone vs. chemoradiation (log-rank test, p < 0.001). (b) Overall survival of patients treated with

Chemotherapy and overall survival. (a) A significant difference in overall survival between radiation alone vs. chemoradiation (log-rank test, p < 0.001). (b) Overall survival of patients treated with sequential chemoradiation or concurrent chemoradiation vs. radiation alone (log-rank test, p < 0.001).
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Radiation dose and overall survival. (a) The distribution of bioequivalent dose (BED) in patients treated with radiation alone, sequential chemoradiation, or concurrent chemoradiation. (b) The relatio

Radiation dose and overall survival. (a) The distribution of bioequivalent dose (BED) in patients treated with radiation alone, sequential chemoradiation, or concurrent chemoradiation. (b) The relationship of survival over BED for all individual patients, showing that BED was a significant factor for overall survival (Cox-regression analysis, continuous covariate, p < 0.001). CI = confidence interval.
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Note—An online CME test for this article can be taken at http://asro.astro.org under Continuing Education.

The study was presented at the 49th annual American Society for Therapeutic Radiology and Oncology (ASTRO) meeting, held October 30, 2007, in Los Angeles. It was named “Best of ASTRO 2007,” and was quoted at the third Annual Mid-Atlantic ASTRO Review Course on January 10, 2008, at the University of Maryland.

Conflict of interest: none.

PII: S0360-3016(08)03057-5

doi: 10.1016/j.ijrobp.2008.06.1935

« Previous Next » International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1383-1390 , 1 April 2009