International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1414-1424 , 1 April 2009

Microscopic and Macroscopic Tumor and Parenchymal Effects of Liver Stereotactic Body Radiotherapy

  • C.C. Olsen, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado, Denver, Aurora, CO
  • ,
  • J. Welsh, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Arizona, Tucson, AZ
  • ,
  • B.D. Kavanagh, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado, Denver, Aurora, CO
  • ,
  • W. Franklin, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado, Denver, Aurora, CO
  • ,
  • M. McCarter, M.D.

      Affiliations

    • Department of Surgery, University of Colorado, Denver, Aurora, CO
  • ,
  • H.R. Cardenes, M.D.

      Affiliations

    • Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN
  • ,
  • L.E. Gaspar, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado, Denver, Aurora, CO
  • ,
  • T.E. Schefter, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Colorado, Denver, Aurora, CO
    • Corresponding Author InformationReprint requests to: Tracey E. Schefter, M.D., Department of Radiation Oncology, University of Colorado Denver, 1665 N. Ursula St., Suite 1032, Aurora, CO 80045-000508. Tel: (720) 848-0116; Fax: (720) 848-0238

Received 29 May 2008 ,Accepted 3 July 2008.

References 

  1. Blomgren H, Lax I, Goranson He, et al. Radiosurgery for tumors in the body: Clinical experience using a new method. J Radiosurg. 1998;1:63–74
  2. Herfarth KK, Debus J, Lohr F, et al. Stereotactic single dose radiation therapy of liver tumors: Results of a phase I/II trial. J Clin Oncol. 2001;19:164–170
  3. Wulf J, Hadinger U, Oppitz U, et al. Stereotactic radiotherapy of targets in the lung and liver. Strahlenther Onkol. 2001;177:645–655
  4. Kavanagh BD, Schefter TE, Cardenes HR, et al. Interim analysis of a prospective phase I/II trial of SBRT for liver metastases. Acta Oncol. 2006;45:848–855
  5. Ingold JA, Reed GB, Kaplan HS, et al. Radiation hepatitis. AJR Am J Roentgenol. 1965;93:200–208
  6. Reed GB, Cox AJ. The human liver after radiation injury. Am J Pathol. 1966;48:597–611
  7. Lawrence TS, Robertson JM, Anscher MS, et al. Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys. 1995;31:1237–1248
  8. Hakin R, Zervas N, Hakim F, et al. Initial characterization of the dosimetry and radiobiology of a device for administering interstitial stereotactic radiosurgery. Neurosurgery. 1997;40:510–517
  9. Unger EC, Lee JKT, Weyman PJ. CT and MR imaging of radiation hepatitis. J Comput Assist Tomogr. 1987;11:264–268
  10. Okumura T, Itai Y, Tsuji H, et al. Focused radiation hepatitis after Bragg-peak proton therapy for hepatocellular carcinoma: CT findings. J Comput Assist Tomogr. 1994;18:821–823
  11. Willemart S, Nicaise N, Struyven J, et al. Acute radiation-induced hepatic injury: Evaluation by triphasic contrast enhanced helical CT. Br J Radiol. 2000;73:544–546
  12. Jeffrey RB, Moss AA, Quivey JM, et al. CT of radiation-induced hepatic injury. AJR Am J Roentgenol. 1980;135:445–448
  13. Herfarth KK, Holfer H, Bahner ML, et al. Assessment of focal liver reaction by multiphasic CT after stereotactic singe-dose radiotherapy of liver tumors. Int J Radiat Oncol Biol Phys. 2003;57:444–451
  14. Schefter TE, Kavanagh BD, Timmerman RD, et al. Phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases. Int J Radiat Oncol Biol Phys. 2005;62:1371–1378
  15. Mendez Romero A, Wunderink W, Hussain SM, et al. Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase I-II study. Acta Oncol. 2006;45:831–837
  16. McCammon R, Schefter TE, Zaemisch R, et al. Observation of a dose-control relationship for extra-cranial tumors after stereotactic body radiation therapy (SBRT). Int J Radiat Oncol Biol Phys. 2009;73:112–118
  17. Fajardo LF, Berthrong M, Anderson RE. Liver. In:  Fajardo LF,  Berthrong M,  Anderson RE editor. Radiation pathology. Oxford: Oxford University Press; 2001;p. 249–257
  18. Shah SA, Bromberg R, Coates A, et al. Survival after liver resection for metastatic colorectal carcinoma in a large population. J Am Coll Surg. 2007;205:676–683
  19. González HD, Figueras J. Practical questions in liver metastases of colorectal cancer: General principles of treatment. HPB (Oxford). 2007;9:251–258
  20. Giraudo G, Greget M, Oussoultzoglou E, et al. Preoperative contralateral portal vein embolization before major hepatic resection is a safe and efficient procedure: A large single institution experience. Surgery. 2008;143:476–482
  21. Anscher MS, Peters WP, Reisenbichler H, et al. Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer. N Engl J Med. 1993;328:1592–1598

 Partially presented at the 2007 Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Los Angeles, CA.

 Conflict of interest: none.

PII: S0360-3016(08)03171-4

doi: 10.1016/j.ijrobp.2008.07.032

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1414-1424 , 1 April 2009