International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1313-1318 , 1 April 2009

Outcome Prediction After Surgery and Chemoradiation of Squamous Cell Carcinoma in the Oral Cavity, Oropharynx, and Hypopharynx: Use of Baseline Perfusion CT Microcirculatory Parameters vs. Tumor Volume

  • Sotirios Bisdas, M.D.

      Affiliations

    • Department of Radiology, Medical University of South Carolina, Charleston, SC
  • ,
  • Shaun A. Nguyen, M.D., M.A.

      Affiliations

    • Department of Radiology, Medical University of South Carolina, Charleston, SC
    • Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, SC
  • ,
  • Sharma K. Anand, M.D.

      Affiliations

    • Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC
  • ,
  • Gordana Glavina, M.D.

      Affiliations

    • Department of Radiology, Medical University of South Carolina, Charleston, SC
  • ,
  • Terry Day, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, SC
  • ,
  • Zoran Rumboldt, M.D.

      Affiliations

    • Department of Radiology, Medical University of South Carolina, Charleston, SC
    • Corresponding Author InformationReprint requests to: Zoran Rumboldt, MD, Department of Radiology, Medical University of South Carolina, 169 Ashley Avenue, SC, 29425. Tel: (843) 792-1573; Fax: (843) 792-1705

Received 22 February 2008 ,Revised 15 June 2008 ,Accepted 23 June 2008.

References 

  1. Lavaf A, Genden EM, Cesaretti JA, et al. Adjuvant radiotherapy improves overall survival for patients with lymph node-positive head and neck squamous cell carcinoma. Cancer. 2008;112:535–543
  2. Million RR. Squamous cell carcinoma of the head and neck: combined therapy: Surgery and postoperative irradiation. Int J Radiat Oncol Biol Phys. 1979;5:2161–2162
  3. Winquist E, Oliver T, Gilbert R. Postoperative chemoradiotherapy for advanced squamous cell carcinoma of the head and neck: A systematic review with meta-analysis. Head Neck. 2007;29:38–46
  4. Baghi M, Mack MG, Hambek M, et al. Usefulness of MRI volumetric evaluation in patients with squamous cell cancer of the head and neck treated with neoadjuvant chemotherapy. Head Neck. 2007;29:104–108
  5. Ljumanovic R, Langendijk JA, Schenk B, et al. Supraglottic carcinoma treated with curative radiation therapy: Identification of prognostic groups with MR imaging. Radiology. 2004;232:440–448
  6. Schmitt P, Kotas M, Tobermann A, et al. Quantitative tissue perfusion measurements in head and neck carcinoma patients before and during radiation therapy with a non-invasive MR imaging spin-labeling technique. Radiother Oncol. 2003;67:27–34
  7. Zima A, Carlos R, Gandhi D, et al. Can pretreatment CT perfusion predict response of advanced squamous cell carcinoma of the upper aerodigestive tract treated with induction chemotherapy?. AJNR Am J Neuroradiol. 2007;28:328–334
  8. Hermans R, Meijerink M, Van den Bogaert W, et al. Tumor perfusion rate determined noninvasively by dynamic computed tomography predicts outcome in head-and-neck cancer after radiotherapy. Int J Radiat Oncol Biol Phys. 2003;57:1351–1356
  9. Gandhi D, Chepeha DB, Miller T, et al. Correlation between initial and early follow-up CT perfusion parameters with endoscopic tumor response in patients with advanced squamous cell carcinomas of the oropharynx treated with organ-preservation therapy. AJNR Am J Neuroradiol. 2006;27:101–106
  10. Breiman RS, Beck JW, Korobkin M, et al. Volume determinations using computed tomography. AJR Am J Roentgenol. 1982;138:329–333
  11. Christensen E. Multivariate survival analysis using Cox's regression model. Hepatology. 1987;7:1346–1358
  12. Walters SJ, Campbell MJ. The use of bootstrap methods for analysing health-related quality of life outcomes (particularly the SF-36). Health Qual Life Outcomes. 2004;2:70
  13. Mancuso AA, Mukherji SK, Schmalfuss I, et al. Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. J Clin Oncol. 1999;17:631–637
  14. Hermans R, Van den Bogaert W, Rijnders A, et al. Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys. 1999;44:755–765
  15. Keberle M, Hoppe F, Dotzel S, et al. [Prognostic value of pretreatment CT regarding local control in oropharyngeal cancer after primary surgical resection]. Rofo. 2003;175:61–66
  16. Kurek R, Kalogera-Fountzila A, Muskalla K, et al. Usefulness of tumor volumetry as a prognostic factor of survival in head and neck cancer. Strahlenther Onkol. 2003;179:292–297
  17. Hermans R, Op de beeck K, Van den Bogaert W, et al. The relation of CT-determined tumor parameters and local and regional outcome of tonsillar cancer after definitive radiation treatment. Int J Radiat Oncol Biol Phys. 2001;50:37–45
  18. Nathu RM, Mancuso AA, Zhu TC, et al. The impact of primary tumor volume on local control for oropharyngeal squamous cell carcinoma treated with radiotherapy. Head Neck. 2000;22:1–5
  19. Kao J, Lavaf A, Teng MS, et al. Adjuvant radiotherapy and survival for patients with node-positive head and neck cancer: an analysis by primary site and nodal stage. Int J Radiat Oncol Biol Phys. 2008;71:362–370
  20. Rumboldt Z, Al-Okaili R, Deveikis JP. Perfusion CT for head and neck tumors: Pilot study. AJNR Am J Neuroradiol. 2005;26:1178–1185
  21. Bisdas S, Baghi M, Smolarz A, et al. Quantitative measurements of perfusion and permeability of oropharyngeal and oral cavity cancer, recurrent disease, and associated lymph nodes using first-pass contrast-enhanced computed tomography studies. Invest Radiol. 2007;42:172–179
  22. Hermans R, Lambin P, Van der Goten A, et al. Tumoural perfusion as measured by dynamic computed tomography in head and neck carcinoma. Radiother Oncol. 1999;53:105–111
  23. Tannock IF. Experimental chemotherapy and concepts related to the cell cycle. Int J Radiat Biol Relat Stud Phys Chem Med. 1986;49:335–355
  24. Cao Y, Nagesh V, Hamstra D, et al. The extent and severity of vascular leakage as evidence of tumor aggressiveness in high-grade gliomas. Clin Cancer Res. 2006;66:8912–8917
  25. Martone T, Rosso P, Albera R, et al. Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome. Oral Oncol. 2005;41:147–155
  26. Calvin DP, Hammond ME, Pajak TF, et al. Microvessel density > or =60 does not predict for outcome after radiation treatment for locally advanced head and neck squamous cell carcinoma: Results of a correlative study from the Radiation Therapy Oncology Group (RTOG) 90-03 Trial. Am J Clin Oncol. 2007;30:406–419
  27. Claffey KP, Brown LF, del Aguila LF, et al. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res. 1996;56:172–181
  28. Bisdas S, Konstantinou GN, Lee PS, et al. Dynamic contrast-enhanced CT of head and neck tumors: Perfusion measurements using a distributed-parameter tracer kinetic model. Initial results and comparison with deconvolution-based analysis. Phys Med Biol. 2007;52:6181–6196

 Conflicts of interest: none

PII: S0360-3016(08)03184-2

doi: 10.1016/j.ijrobp.2008.06.1956

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1313-1318 , 1 April 2009