International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 2 , Pages 377-382 , 1 June 2009

Variation in the Definition of Clinical Target Volumes for Pelvic Nodal Conformal Radiation Therapy for Prostate Cancer

  • Colleen A.F. Lawton, M.D.

      Affiliations

    • Medical College of Wisconsin, Milwaukee, WI
    • Corresponding Author InformationReprint requests to: Colleen A. Lawton, M.D., Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee WI 53226. Tel: (414) 805-4472; Fax: (414) 805-4369
    • ,
  • Jeff Michalski, M.D.

      Affiliations

    • Washington University, St Louis, MO
    • ,
  • Issam El-Naqa, Ph.D.

      Affiliations

    • Mallinckrodt Institute of Radiology, St. Louis, MO
    • ,
  • Deborah Kuban, M.D.

      Affiliations

    • MD Anderson, Houston, TX
    • ,
  • W. Robert Lee, M.D.

      Affiliations

    • Wake Forest University School of Medicine, Winston-Salem, NC
    • ,
  • Seth A. Rosenthal, M.D.

      Affiliations

    • Radiation Oncology Center, Radiological Associates of Sacramento, Sacramento, CA
    • ,
  • Anthony Zietman, M.D.

      Affiliations

    • Massachusetts General Hospital, Boston, MA
    • ,
  • Howard Sandler, M.D.

      Affiliations

    • University of Michigan Medical Center, Ann Arbor, MI
    • ,
  • William Shipley, M.D.

      Affiliations

    • Massachusetts General Hospital, Boston, MA
    • ,
  • Mark Ritter, M.D.

      Affiliations

    • University of Wisconsin School of Medicine and Public Health, Madison, WI
    • ,
  • Richard Valicenti, M.D.

      Affiliations

    • Thomas Jefferson University, Philadelphia, PA
    • ,
  • Charles Catton, M.D.

      Affiliations

    • Princess Margaret Hospital, Ontario, CANADA
    • ,
  • Mack Roach III, M.D.

      Affiliations

    • UCSF Comprehensive Cancer Center, San Francisco, CA
    • ,
  • Thomas M. Pisansky, M.D.

      Affiliations

    • Mayo Clinic, Rochester, MN
    • ,
  • Michael Seider, M.D.

      Affiliations

    • Akron City Hospital, Akron, OH

Received 18 June 2008 ,Revised 30 July 2008 ,Accepted 2 August 2008.

References 

  1. Pilepich M, Winter K, Lawton C, et al. Androgen suppression adjuvant to definitive radiotherapy in prostate carcinoma long term results of phase III RTOG 85-31. Int J Radiat Oncol Biol Phys. 2005;61:1285–1290
  2. Roach M, Bae K, Speight J, et al. Short term neoadjuvant androgen deprivation therapy and external beam radiotherapy for locally advanced prostate cancer: Long term results of RTOG 8610 a Phase III prospective randomized trial. J Clin Oncol. 2008;26:585–591
  3. Bolla M, Collette L, Blank L, et al. Long term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study, a phase III randomized trial). Lancet. 2002;360:103–108
  4. Horwitz E, Bae K, Hanks G, et al. Ten-year follow-up of RTOG 92-02: A phase III trial of the duration of elective androgen deprivation in locally advanced prostate cancer. J Clin Oncol. 2008;26:2497–2504
  5. Lawton C, DeSilvio M, Roach M, et al. An update of the phase III trial comparing whole-pelvic (WP) to prostate only (PO) radiotherapy and neoadjuvant to adjuvant total androgen suppression (TAS): Updated analysis of RTOG 94-13, with emphasis on unexpected hormone/radiation interactions. Int J Radiat Oncol Biol Phys. 2007;69:646–655
  6. Roach M, DeSilvio M, Valicenti R, et al. Whole-pelvis, “mini-pelvis,” or prostate-only external beam radiotherapy after neoadjuvant and concurrent hormonal therapy in patients treated in the Radiation Therapy Oncology Group 9413 trial. Int J Radiat Oncol Biol Phys. 2006;66:647–653
  7. Seaward SA, Weinberg V, Lewis P, et al. Improved freedom from PSA failure with whole pelvic irradiation for high risk prostate cancer. Int J Radiat Oncol Biol Phys. 1998;42:1055–1062
  8. RTOG 05-21: A phase III protocol of androgen suppression (AS) and 3D CRT/IMRT vs AS and 3D CRT/IMRT followed by chemotherapy with docetaxel and prednisone for localized high risk prostate cancer. Available at: http://rtog.org. Accessed September 10, 2008.
  9. RTOG 05-34: A phase III trial of short term androgen deprivation with pelvic lymph node or prostate bed only radiotherapy (SPPORT) in prostate cancer patients with a rising PSA after radical prostatectomy. Available at: http://rtog.org. Accessed September 10, 2008.
  10. Fleiss JL. Statistical methods for rates and proportions. 2nd ed.. New York: Wiley; 1981;
  11. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–174
  12. Warfield SK, Zou KH, Wells WM. Simultaneous truth and performance level estimation (STAPLE): an algorithm for the validation of image segmentation. IEEE Trans Med Imaging. 2004;23:903–921

 Supported by NIH U24 grant CA81647, “Advanced Technology QA Center.”

 Conflict of interest: none

PII: S0360-3016(08)03267-7

doi: 10.1016/j.ijrobp.2008.08.003

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 2 , Pages 377-382 , 1 June 2009

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