International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 1 , Pages 49-55 , 1 September 2009

Potential for Higher Treatment Failure in Obese Patients: Correlation of Elevated Body Mass Index and Increased Daily Prostate Deviations From the Radiation Beam Isocenters in an Analysis of 1,465 Computed Tomographic Images

  • James R. Wong, M.D.

      Affiliations

    • Department of Radiation Oncology, The Carol G. Simon Cancer Center, Morristown Memorial Hospital, Morristown, NJ
    • Corresponding Author InformationReprint requests to: James R. Wong, M.D., Department of Radiation Oncology, The Carol G. Simon Cancer Center, Morristown Memorial Hospital, Morristown, NJ 07962. Tel: (973) 971-6233; Fax: (973) 290-7393
  • ,
  • Zhanrong Gao, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The Carol G. Simon Cancer Center, Morristown Memorial Hospital, Morristown, NJ
  • ,
  • Scott Merrick, B.Sc.

      Affiliations

    • Department of Radiation Oncology, The Carol G. Simon Cancer Center, Morristown Memorial Hospital, Morristown, NJ
  • ,
  • Paula Wilson, B.Sc.

      Affiliations

    • Department of Radiation Oncology, The Carol G. Simon Cancer Center, Morristown Memorial Hospital, Morristown, NJ
  • ,
  • Minoru Uematsu, M.D.

      Affiliations

    • Radiation Oncology, Uematsu-Atsuchi-Serendipity Oncology Center, Terukuni, Kagoshima, Japan
  • ,
  • Kevin Woo, B.Sc.

      Affiliations

    • Department of Radiation Oncology, The Carol G. Simon Cancer Center, Morristown Memorial Hospital, Morristown, NJ
  • ,
  • Chee-Wai Cheng, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The Carol G. Simon Cancer Center, Morristown Memorial Hospital, Morristown, NJ

Received 3 April 2008 ,Revised 28 July 2008 ,Accepted 31 July 2008.

References 

  1. Stroup SP, Cullen J, Auge BK, et al. Effect of obesity on prostate-specific antigen recurrence after radiation therapy for localized prostate cancer as measured by the 2006 Radiation Therapy Oncology Group–American Society for Therapeutic Radiation and Oncology (RTOG-ASTRO) Phoenix consensus definition. Cancer. 2007;110:1003–1009
  2. Efstathiou JA, Chen MH, Renshaw AA, et al. Influence of body mass index on prostate-specific antigen failure after androgen suppression and radiation therapy for localized prostate cancer. Cancer. 2007;109:1493–1498
  3. Strom SS, Kamat AM, Gruschkus SK, et al. Influence of obesity on biochemical and clinical failure after external-beam radiotherapy for localized prostate cancer. Cancer. 2006;107:631–639
  4. Merrick GS, Galbreath RW, Butler WM, et al. Obesity is not predictive of overall survival following permanent prostate brachytherapy. Am J Clin Oncol. 2007;30:588–596
  5. Merrick GS, Butler WM, KWallner KE, et al. Influence of Body Mass Index on Biochemical Outcome After Permanent Prostate Brachytherapy. Urology. 2005;65:95–100
  6. Freedland SJ, Grubb KA, Yiu SK, et al. Obesity and risk of biochemical progression following radical prostatectomy at a tertiary care referral center. J Urol. 2005;174:919–922
  7. Amling CL, Riffenburgh RH, Sun L, et al. Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy. J Clin Oncol. 2004;22:439–445
  8. Siddiqui SA, Inman BA, Sengupta S, et al. Obesity and survival after radical prostatectomy: A 10-year prospective cohort study. Cancer. 2006;107:521–529
  9. Millender LE, Aubin M, Pouliot J, et al. Daily electronic portal imaging for morbidly obese men undergoing radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2004;59:6–10
  10. Yan D, Lockman D. Organ/patient geometric variation in external beam radiotherapy and its effects. Med Phys. 2001;28:593–602
  11. Wong JR, Grimm L, Uematsu M, et al. Image-guided radiotherapy for prostate cancer by CT-linear accelerator combination: Prostate movements and dosimetric considerations. Int J Radiat Oncol Biol Phys. 2005;61:561–569
  12. Crook JM, Raymond Y, Salhani D, et al. Prostate motion during standard radiotherapy as assessed by fiducial markers. Radiother Oncol. 1995;37:35–42
  13. Bayley AJ, Catton CN, Haycocks T, et al. A randomized trial of supine vs. prone positioning in patients undergoing escalated dose conformal radiotherapy for prostate cancer. Radiother Oncol. 2004;70:37–44
  14. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295:1549–1555
  15. Cheng CW, Wong J, Grimm L, et al. Commissioning and clinical implementation of a sliding gantry CT scanner installed in an existing treatment room and early clinical experience for precise tumor localization. Am J Clin Oncol. 2003;26:e28–e36
  16. Wong JR, Gao Z, Merrick S, et al. Interfractional prostate shifts—review of 1870 CT scans obtained during image guided radiation therapy using a CT-on-rails for the treatment of prostate cancer. Int J Radiat Oncol Biol Phys. 2008;72:1396–1401
  17. Lehmann EL. Nonparametrics: Statistical methods based on ranks, revised facsimile. Englewood Cliffs, NJ: Prentice-Hall; 1998;
  18. Wu J, Haycocks T, Alasti H, et al. Positioning errors and prostate motion during conformal prostate radiotherapy using on-line isocentre set-up verification and implanted prostate markers. Radiother Oncol. 2001;61:127–133
  19. van Herk M, Bruce A, Kroes AP, et al. Quantification of organ motion during conformal radiotherapy of the prostate by three dimensional image registration. Int J Radiat Oncol Biol Phys. 1995;33:1311–1320
  20. Huang E, Dong L, Chandra A, et al. Intrafraction prostate motion during IMRT for prostate cancer. Int J Radiat Oncol Biol Phys. 2002;53:261–268
  21. Alasti H, Petric MP, Catton CN, et al. Portal imaging for evaluation of daily on-line setup errors and off-line organ motion during conformal irradiation of carcinoma of the prostate. Int J Radiat Oncol Biol Phys. 2001;49:869–884
  22. Mackie TR, Kapatoes J, Ruchala K, et al. Image guidance for precise conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2003;56:89–105
  23. Jaffray DA, Siewerdsen JH, Wong JW, et al. Flat-panel cone-beam computed tomography for image-guided radiation therapy. Int J Radiat Oncol Biol Phys. 2002;53:1337–1349
  24. Serago CF, Chungbin SJ, Buskirk SJ, et al. Initial experience with ultrasound localization for positioning prostate cancer patients for external beam radiotherapy. Int J Radiat Oncol Biol Phys. 2002;53:1130–1138

 Conflict of interest: none.

PII: S0360-3016(08)03281-1

doi: 10.1016/j.ijrobp.2008.07.049

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 1 , Pages 49-55 , 1 September 2009