International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 1 , Pages 55-59 , 1 May 2009

Use of Molecular Imaging to Predict Clinical Outcome in Patients With Rectal Cancer After Preoperative Chemotherapy and Radiation

  • Andre Konski, M.D., M.B.A., M.A.

      Affiliations

    • Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA
    • Corresponding Author InformationReprint requests to: Andre Konski, M.D., M.B.A., M.A., Department of Radiation Oncology, 333 Cottman Ave. Philadelphia, PA 19111. Tel: (215) 728-2916; Fax: (215) 214-1629
    • ,
  • Tianyu Li, M.S.

      Affiliations

    • Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA
    • ,
  • Elin Sigurdson, M.D.

      Affiliations

    • Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA
    • ,
  • Steven J. Cohen, M.D.

      Affiliations

    • Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA
    • ,
  • William Small Jr., M.D.

      Affiliations

    • Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
    • ,
  • Stewart Spies, M.D.

      Affiliations

    • Department of Nuclear Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
    • ,
  • Jian Q. Yu, M.D.

      Affiliations

    • Nuclear Medicine, Department of Diagnostic Imaging, Fox Chase Cancer Center, Philadelphia, PA
    • ,
  • Andrew Wahl, M.D.

      Affiliations

    • Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
    • ,
  • Steven Stryker, M.D.

      Affiliations

    • Department of Surgery, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
    • ,
  • Neal J. Meropol, M.D.

      Affiliations

    • Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA

Received 14 March 2008 ,Revised 28 July 2008 ,Accepted 31 July 2008.

References 

  1. Konski A, Hoffman J, Sigurdson E, et al. Can molecular imaging predict response to preoperative chemoradiation in patients with rectal cancer? A Fox Chase Cancer Center prospective experience. Semin Oncol. 2005;32:S63–S67
  2. Konski A, Doss M, Milestone B, et al. The integration of 18-fluoro-deoxy-glucose positron emission tomography and endoscopic ultrasound in the treatment-planning process for esophageal carcinoma. Int J Radiat Oncol Biol Phys. 2005;61:1123–1128
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  8. Oku S, Nakagawa K, Momose T, et al. FDG-PET after radiotherapy is a good prognostic indicator of rectal cancer. Ann Nucl Med. 2002;16:409–416
  9. Amthauer H, Denecke T, Rau B, et al. Response prediction by FDG-PET after neoadjuvant radiochemotherapy and combined regional hyperthermia of rectal cancer: Correlation with endorectal ultrasound and histopathology. Eur J Nucl Med Mol Imaging. 2004;31:811–819
  10. Denecke T, Rau B, Hoffmann KT, et al. Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: Is there a benefit in using functional imaging?. Eur Radiol. 2005;15:1658–1666
  11. Guillem JG, Moore HG, Akhurst T, et al. Sequential preoperative fluorodeoxyglucose-positron emission tomography assessment of response to preoperative chemoradiation: A means for determining longterm outcomes of rectal cancer. J Am Coll Surg. 2004;199:1–7
  12. Guillem JG, Puig-La Calle J, Akhurst T, et al. Prospective assessment of primary rectal cancer response to preoperative radiation and chemotherapy using 18-fluorodeoxyglucose positron emission tomography. Dis Colon Rectum. 2000;43:18–24
  13. Capirci C, Rubello D, Chierichetti F, et al. Restaging after neoadjuvant chemoradiotherapy for rectal adenocarcinoma: Role of F18-FDG PET. Biomed Pharmacother. 2004;58:451–457
  14. Moore HG, Gittleman AE, Minsky BD, et al. Rate of pathologic complete response with increased interval between preoperative combined modality therapy and rectal cancer resection. Dis Colon Rectum. 2004;47:279–286
  15. Habr-Gama A, Perez RO, Nadalin W, et al. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: Long-term results. Ann Surg. 2004;240:711–717discussion 717–718
  16. Capirci C, Rubello D, Chierichetti F, et al. Long-term prognostic value of 18F-FDG PET in patients with locally advanced rectal cancer previously treated with neoadjuvant radiochemotherapy. AJR Am J Roentgenol. 2006;187:W202–W208
  17. Cascini GL, Avallone A, Delrio P, et al. 18F-FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer. J Nucl Med. 2006;47:1241–1248

 Presented at the 88th Annual Meeting of the American Radium Society, May 7th-10, 2006

 Conflict of interest: none.

PII: S0360-3016(08)03283-5

doi: 10.1016/j.ijrobp.2008.07.050

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 1 , Pages 55-59 , 1 May 2009

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