International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 1 , Pages 1-8 , 1 May 2009

Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of a Nonrandomized Prospective Study Using a Standardized Follow-Up Program

  • Marije R. Vergeer, M.D.

      Affiliations

    • Department of Radiation Oncology, VU University Medical Center, Amsterdam, the Netherlands
    • Corresponding Author InformationReprint requests to: Marije R. Vergeer, M.D., Department of Radiation Oncology, University Hospital VU University, PO Box 7057, 1007 MB Amsterdam, The Netherlands. Tel: (+31) 20-4440413; Fax: (+31) 20-4440410l
    • ,
  • Patricia A.H. Doornaert, M.D.

      Affiliations

    • Department of Radiation Oncology, VU University Medical Center, Amsterdam, the Netherlands
    • ,
  • Derek H.F. Rietveld, M.D.

      Affiliations

    • Department of Radiation Oncology, VU University Medical Center, Amsterdam, the Netherlands
    • ,
  • C. René Leemans, M.D., Ph.D.

      Affiliations

    • Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam, the Netherlands
    • ,
  • Ben J. Slotman, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, VU University Medical Center, Amsterdam, the Netherlands
    • ,
  • Johannes A. Langendijk, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands

Received 17 March 2008 ,Revised 13 June 2008 ,Accepted 28 July 2008.

References 

  1. Bjordal K, Kaasa S, Mastekaasa A. Quality of life in patients treated for head and neck cancer: A follow-up study 7 to 11 years after radiotherapy. Int J Radiat Oncol Biol Phys. 1994;28:847–856
  2. Xia P, Fu KK, Wong GW, et al. Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2000;48:329–337
  3. Roesink JM, Moerland MA, Battermann JJ, et al. Quantitative dose-volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region. Int J Radiat Oncol Biol Phys. 2001;51:938–946
  4. Eisbruch A, Ten Haken RK, Kim HM, et al. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys. 1999;45:577–587
  5. Eisbruch A, Ship JA, Dawson LA, et al. Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer. World J Surg. 2003;27:832–837
  6. de Arruda FF, Puri DR, Zhung J, et al. Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: The Memorial Sloan-Kettering Cancer Center experience. Int J Radiat Oncol Biol Phys. 2006;64:363–373
  7. Chao KS, Majhail N, Huang CJ, et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: A comparison with conventional techniques. Radiother Oncol. 2001;61:275–280
  8. Pow EH, Kwong DL, McMillan AS, et al. Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys. 2006;66:981–991
  9. Parliament MB, Scrimger RA, Anderson SG, et al. Preservation of oral health-related quality of life and salivary flow rates after inverse-planned intensity- modulated radiotherapy (IMRT) for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2004;58:663–673
  10. Jabbari S, Kim HM, Feng M, et al. Matched case-control study of quality of life and xerostomia after intensity-modulated radiotherapy or standard radiotherapy for head-and-neck cancer: Initial report. Int J Radiat Oncol Biol Phys. 2005;63:725–731
  11. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 1995;31:1341–1346
  12. Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–376
  13. Bjordal K, Ahlner-Elmqvist M, Tollesson E, et al. Development of a European Organization for Research and Treatment of Cancer (EORTC) questionnaire module to be used in quality of life assessments in head and neck cancer patients. EORTC Quality of Life Study Group. Acta Oncol. 1994;33:879–885
  14. Gregoire V, Coche E, Cosnard G, et al. Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience. Radiother Oncol. 2000;56:135–150
  15. Fogliata A, Cozzi L, Bieri S, Bernier J. Critical appraisal of a conformal head and neck cancer irradiation avoiding electron beams and field matching. Int J Radiat Oncol Biol Phys. 1999;45:1331–1338
  16. Jellema AP, Slotman BJ, Doornaert P, et al. Impact of radiation induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer. Int J Radiat Oncol Biol Phys. 2007;69:751–760
  17. Graff P, Lapeyre M, Desandes E, et al. Impact of intensity-modulated radiotherapy on health-related quality of life for head and neck cancer patients: Matched-pair comparison with conventional radiotherapy. Int J Radiat Oncol Biol Phys. 2007;67:1309–1317
  18. Eisbruch A, Kim HM, Terrell JE, et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;50:695–704
  19. Jellema AP, Doornaert P, Slotman BJ, et al. Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?. Radiother Oncol. 2005;77:164–171
  20. Meirovitz A, Murdoch-Kinch CA, Schipper M, et al. Grading xerostomia by physicians or by patients after intensity-modulated radiotherapy of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2006;66:445–453
  21. Vissink A, Burlage FR, Spijkervet FK, et al. Prevention and treatment of the consequences of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003;14:213–225
  22. Levendag PC, Teguh DN, Voet P, et al. Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: A dose-effect relationship. Radiother Oncol. 2007;85:64–73
  23. Eisbruch A, Schwartz M, Rasch C, et al. Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT?. Int J Radiat Oncol Biol Phys. 2004;60(5):1425–1439
  24. Rosenthal DI, Chambers MS, Fuller CD, et al. Beam path toxicities to non-target structures during intensity-modulated radiation therapy for head and neck cancer. Int J Radiat Oncol Biol Phys. May 1, 2008;[Epub ahead of print]
  25. Cannon DM, Lee NY. Recurrence in region of spared parotid gland after definitive intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 2008;70:657–659
  26. Schoenfeld GO, Amdur RJ, Morris CG, et al. Patterns of failure and toxicity after intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 2008;71:377–385

 Presented in part at the European Society for Therapeutic Radiology and Oncology International Meeting on innovative approaches in head and neck oncology, Barcelona, Spain, February 22–24, 2007 (oral presentation); the First World Congress of the International Academy of Oral Oncology, Amsterdam, the Netherlands, May 17–20, 2007 (oral presentation); and the American Society for Therapeutic Radiology and Oncology 49th Annual Meeting, Los Angeles, November 27–December 01, 2007 (poster presentation).

 Conflict of interest: none.

PII: S0360-3016(08)03311-7

doi: 10.1016/j.ijrobp.2008.07.059

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 1 , Pages 1-8 , 1 May 2009

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