International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 2 , Pages 412-418 , 1 June 2009

Simultaneous Multitarget Irradiation Using Helical Tomotherapy for Advanced Hepatocellular Carcinoma With Multiple Extrahepatic Metastases

  • Jeong Won Jang, M.D.

      Affiliations

    • Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, Korea
    • Corresponding Author InformationReprint requests to: Jeong Won Jang, M.D., Department of Internal Medicine, Catholic University of Korea College of Medicine, No. 665 Bupyeong-dong, Bupyeong-gu, Incheon, 403-720 South Korea. Tel: (+82) 32-510-5682; Fax: (+82) 32-510-5683
    • ,
  • Chul Seung Kay, M.D.

      Affiliations

    • Department of Radiation Oncology, Catholic University of Korea College of Medicine, Seoul, Korea
    • Corresponding Author InformationChul Seung Kay, M.D., Department of Radiation Oncology, Catholic University of Korea College of Medicine, No. 665 Bupyeong-dong, Bupyeong-gu, Incheon, 403-720 South Korea. Tel: (+82) 32-510-5682; Fax: (+82) 32-510-5683
    • ,
  • Chan Ran You, M.D.

      Affiliations

    • Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, Korea
    • ,
  • Chang Wook Kim, M.D.

      Affiliations

    • Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, Korea
    • ,
  • Si Hyun Bae, M.D.

      Affiliations

    • Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, Korea
    • ,
  • Jong Young Choi, M.D.

      Affiliations

    • Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, Korea
    • ,
  • Seung Kew Yoon, M.D.

      Affiliations

    • Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, Korea
    • ,
  • Chi Wha Han, M.D.

      Affiliations

    • Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, Korea
    • ,
  • Hyun Suk Jung, M.D.

      Affiliations

    • Department of Radiology, Catholic University of Korea College of Medicine, Seoul, Korea
    • ,
  • Ihl Bong Choi, M.D.

      Affiliations

    • Department of Radiation Oncology, Catholic University of Korea College of Medicine, Seoul, Korea

Received 17 June 2008 ,Accepted 5 August 2008.

References 

  1. Lo CM, Ngan H, Tso WK, et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology. 2002;35:1164–1171
  2. Llovet JM, Real MI, Montana X, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial. Lancet. 2002;359:1734–1739
  3. Uka K, Aikata H, Takaki S, et al. Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma. World J Gastroenterol. 2007;13:414–420
  4. Okusaka T, Okada S, Ishii H, et al. Prognosis of hepatocellular carcinoma patients with extrahepatic metastases. Hepatogastroenterology. 1997;44:251–257
  5. Stillwagon GB, Order SE, Guse C, et al. 194 Hepatocellular cancers treated by radiation and chemotherapy combinations: Toxicity and response—A Radiation Therapy Oncology Group study. Int J Radiat Oncol Biol Phys. 1989;17:1223–1229
  6. Cheng JC, Chuang VP, Cheng SH, et al. Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2000;47:435–442
  7. Ben-Josef E, Normolle D, Ensminger WD, et al. Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies. J Clin Oncol. 2005;23:8739–8747
  8. Seong J, Park HC, Han KH, et al. Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: A retrospective study of 158 patients. Int J Radiat Oncol Biol Phys. 2003;55:329–336
  9. Liu MT, Li SH, Chu TC, et al. Three-dimensional conformal radiation therapy for unresectable hepatocellular carcinoma patients who had failed with or were unsuited for transcatheter arterial chemoembolization. Jpn J Clin Oncol. 2004;34:532–539
  10. Mackie TR, Balog J, Ruchala K, et al. Tomotherapy. Semin Radiat Oncol. 1999;9:108–117
  11. Hong TS, Welsh JS, Ritter MA, et al. Megavoltage computed tomography: An emerging tool for image-guided radiotherapy. Am J Clin Oncol. 2007;30:617–623
  12. Zeng ZC, Tang ZY, Fan J, et al. Consideration of role of radiotherapy for lymph node metastases in patients with HCC: Retrospective analysis for prognostic factors from 125 patients. Int J Radiat Oncol Biol Phys. 2005;63:1067–1076
  13. Ishii H, Furuse J, Kinoshita T, et al. Extrahepatic spread from hepatocellular carcinoma: Who are candidates for aggressive anti-cancer treatment?. Jpn J Clin Oncol. 2004;34:733–739
  14. Seong J, Koom WS, Park HC. Radiotherapy for painful bone metastases from hepatocellular carcinoma. Liver Int. 2005;25:261–265
  15. Jang JW, Park YM, Bae SH, et al. Therapeutic efficacy of multimodal combination therapy using transcatheter arterial infusion of epirubicin and cisplatin, systemic infusion of 5-fluorouracil, and additional percutaneous ethanol injection for unresectable hepatocellular carcinoma. Cancer Chemother Pharmacol. 2004;54:415–420
  16. Therasse P, Arbuck SG, Eisenhauer EA, et al. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst. 2000;92:205–216
  17. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 1995;31:1341–1346
  18. Trotti A, Byhardt R, Stetz J, et al. Common Toxicity Criteria, version 2.0: An improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47:13–47
  19. Jang JW, Choi JY, Bae SH, et al. Transarterial chemo-lipiodolization can reactivate hepatitis B virus replication in patients with hepatocellular carcinoma. J Hepatol. 2004;41:427–435
  20. Jang JW, Choi JY, Bae SH, et al. A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo-lipiodolization. Hepatology. 2006;43:233–240
  21. Natsuizaka M, Omura T, Akaike T, et al. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol. 2005;20:1781–1787
  22. Park KW, Park JW, Choi JI, et al. Survival analysis of 904 patients with hepatocellular carcinoma in a hepatitis B virus-endemic area. J Gastroenterol Hepatol. 2008;23:900–907
  23. Zeng ZC, Tang ZY, Fan J, et al. Radiation therapy for adrenal gland metastases from hepatocellular carcinoma. Jpn J Clin Oncol. 2005;35:61–67
  24. Lam CM, Lo CM, Yuen WK, et al. Prolonged survival in selected patients following surgical resection for pulmonary metastasis from hepatocellular carcinoma. Br J Surg. 1998;85:1198–1200
  25. Kurachi K, Suzuki S, Yokoi Y, et al. A 5-year survivor after resection of peritoneal metastases from pedunculated-type hepatocellular carcinoma. J Gastroenterol. 2002;37:571–574
  26. Nakayama H, Takayama T, Makuuchi M, et al. Resection of peritoneal metastases from hepatocellular carcinoma. Hepatogastroenterology. 1999;46:1049–1052
  27. Chang L, Chen YL, Kao MC. Intracranial metastasis of hepatocellular carcinoma: Review of 45 cases. Surg Neurol. 2004;62:172–177
  28. Zeng ZC, Tang ZY, Fan J, et al. A comparison of chemoembolization combination with and without radiotherapy for unresectable hepatocellular carcinoma. Cancer J. 2004;10:307–316
  29. Kim DY, Park W, Lim DH, et al. Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma. Cancer. 2005;103:2419–2426
  30. Zeng ZC, Fan J, Tang ZY, et al. A comparison of treatment combinations with and without radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombus. Int J Radiat Oncol Biol Phys. 2005;61:432–443
  31. Park YJ, Lim do H, Paik SW, et al. Radiation therapy for abdominal lymph node metastasis from hepatocellular carcinoma. J Gastroenterol. 2006;41:1099–1106
  32. Yamashita H, Nakagawa K, Shiraishi K, et al. Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: Retrospective study. J Gastroenterol Hepatol. 2007;22:523–527
  33. Li B, Yu J, Wang L, et al. Study of local three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for patients with stage III hepatocellular carcinoma. Am J Clin Oncol. 2003;26:e92–e99
  34. Yamada K, Izaki K, Sugimoto K, et al. Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2003;57:113–119
  35. Jang JW, Bae SH, Choi JY, et al. A combination therapy with transarterial chemo-lipiodolization and systemic chemo-infusion for large extensive hepatocellular carcinoma invading portal vein in comparison with conservative management. Cancer Chemother Pharmacol. 2007;59:9–15

 Conflict of interest: none.

PII: S0360-3016(08)03350-6

doi: 10.1016/j.ijrobp.2008.08.034

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 2 , Pages 412-418 , 1 June 2009

Article Tools

* Image Usage & Resolution