International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 1 , Pages 3-5 , 1 January 2009

Chronobiology in Oncology

  • Erhard Haus, M.D., Ph.D.

      Affiliations

    • Corresponding Author InformationReprint requests to: Dr. Erhard Haus, University of Minnesota, HealthPartners Medical Group, Regions Hospital, St. Paul, Minnesota, 55101. Tel: (651) 254-9630; (651) 254-2741

Received 4 August 2008 ,Revised 29 August 2008 ,Accepted 29 August 2008.

References 

  1. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002;418:935–941
  2. Fu L, Lee CC. The circadian clock: Pacemaker and tumour suppressor. Nat Rev Cancer. 2003;3:350–361
  3. Haus E. Chronobiology of the mammalian response to ionizing radiation, potential applications in oncology. Chronobiol Int. 2002;19:77–100
  4. Collis SJ, Boulton SJ. Emerging links between the biological clock and the DNA damage response. Chromosoma. 2007;116:331–339
  5. Matsuo T, Yamaguchi S, Mitsui S, et al. Control mechanism of the circadian clock for timing of cell division in vivo. Science. 2003;302:255–259
  6. Levi F, Focan C, Karaboue A, et al. Implications of circadian clocks for the rhythmic delivery of cancer therapeutics. Adv Drug Deliv Rev. 2007;59:1015–1035
  7. Bjarnason GA, MacKenzie RG, Nabid A, et al. A comparison of toxicity associated with early morning vs late afternoon radiotherapy in patients with head and neck cancer: A prospective randomized trial of the National Cancer Institute of Canada Clinical Trials Group (HN3). Int J Radiat Oncol Biol Phys. 2009;73:166–172
  8. Smaaland R, Sothern RB, Laerum OD, Abrahamsen JF. Rhythms in human bone marrow and blood cells. Chronobiol Internat. 2002;19:101–127
  9. Mormont M-C, Waterhouse J, Bleuzen P, et al. Marked 24-h rest/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status. Clin Cancer Res. 2000;6:3038–3045
  10. Clairambault J. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance. Adv Drug Deliv Rev. 2007;59:1054–1068

 Conflict of interest: none.

PII: S0360-3016(08)03425-1

doi: 10.1016/j.ijrobp.2008.08.045

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 1 , Pages 3-5 , 1 January 2009

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