International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 4 , Pages 1027-1032, 15 July 2009

Development of Dose–Volume Relation Model for Gamma Knife Surgery of Non-Skull Base Intracranial Meningiomas

  • Hyun-Tai Chung, Ph.D.

      Affiliations

    • Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    • ,
  • Dong Gyu Kim, M.D., Ph.D.

      Affiliations

    • Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    • Corresponding Author InformationReprint requests to: Dong Gyu Kim, M.D., Ph.D., Department of Neurosurgery, Seoul National University College of Medicine, 28 Yeongeon-dong Jongno-gu, Seoul 110-744 Korea. Tel: (+82) 22-072-2350; Fax: (+82) 2744-8459
    • ,
  • Sun Ha Paek, M.D.

      Affiliations

    • Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    • ,
  • Hee-Won Jung, M.D.

      Affiliations

    • Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Korea

Received 12 May 2008; received in revised form 1 September 2008; accepted 5 September 2008. published online 03 December 2008.

Purpose

To provide a dose–volume relationship for gamma knife surgery (GKS) of non-skull base intracranial meningiomas.

Methods and Materials

The radiologic outcomes of GKS of 82 imaging-defined benign meningiomas located at non-skull base areas were analyzed. A total of 80 patients were included and all underwent treatment with GKS as the first and the only treatment modality. The mean patient age was 55.0 years (range, 26–78) and the mean tumor volume was 5.6 cm3 (range, 0.5–16.8). On average, 14.6 Gy (range, 10–20) was applied to the 50% isodose surface. The binary logistic regression method was applied to find prognostic factors of signal change (SC) on T2-weighted magnetic resonance imaging after GKS.

Results

The actuarial tumor control rate was 91.6% at 5 years. A total of 29 lesions (35.4%) showed newly developed or aggravated SCs. The volume irradiated ≥14 Gy was the only statistically significant (p < .01) prognostic factor of SC. A dose–volume relation model obtained from the cases without SC estimated a 12.2% SC probability.

Conclusion

This model can be used in GKS to treat small- to medium-size (<9.2 cm3) non-skull base meningiomas.

Radiosurgery, Meningioma, Complications, Radiation dose, Radiation injury

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 Supported in part by the Korea Ministry of Education, Science and Technology (Study No. M20704000057-08M0400-05712).

 Preliminary results presented at the 13th International Meeting of the Leksell Gamma Knife Society, Seoul, Korea, May 2006.

 Conflict of interest: none.

PII: S0360-3016(08)03430-5

doi:10.1016/j.ijrobp.2008.09.007

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 4 , Pages 1027-1032, 15 July 2009

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