International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 4 , Pages 1108-1113 , 15 July 2009

Factors Associated With Severe Acute Esophagitis From Hyperfractionated Radiotherapy With Concurrent Chemotherapy for Limited-Stage Small-Cell Lung Cancer

  • John M. Watkins, M.D.

      Affiliations

    • Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Amy E. Wahlquist, M.S.

      Affiliations

    • Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Keisuke Shirai, M.D.

      Affiliations

    • Department of Medicine, Division of Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Elizabeth Garrett-Mayer, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina
    • Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Eric G. Aguero, M.D.

      Affiliations

    • Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • John A. Fortney, M.D.

      Affiliations

    • Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Carol A. Sherman, M.D.

      Affiliations

    • Department of Medicine, Division of Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Anand K. Sharma, M.D.

      Affiliations

    • Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina
    • Corresponding Author InformationReprint requests to: Anand K. Sharma, M.D., Medical University of South Carolina, Department of Radiation Oncology, 169 Ashley Avenue, Charleston SC 29425; Tel: (843) 792-3271; Fax: (843) 792-5498

Received 13 June 2008 ,Revised 26 August 2008 ,Accepted 17 September 2008.

References 

  1. Turrisi AT, Kim K, Blum R, et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. New Engl J Med. 1999;340:265–271
  2. Werner-Wasik M, Pequignot E, Leeper D, et al. Predictors of severe esophagitis include use of concurrent chemotherapy, but not the length of irradiated esophagus: A multivariate analysis of patients with lung cancer treated with non-operative therapy. Int J Radiat Oncol Biol Phys. 2000;48:689–696
  3. Singh AK, Lockett MA, Bradley JD. Predictors of radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2003;55:337–341
  4. Choi NC, Herndon JE, Rosenman J, et al. Phase I study to determine the maximum-tolerated dose of radiation in standard daily and hyperfractionated-accelerated twice-daily radiation schedules with concurrent chemotherapy for limited-stage small-cell lung cancer. J Clin Oncol. 1998;16:3528–3536
  5. In:  Bonate P,  Howard D editor. Pharmacokinetics in drug development: clinical study design and analysis. New York: Springer Publishing Company; 2005;
  6. Qiao W-B, Zhao Zhao Y-H, Zhao Y-B, et al. Clinical and dosimetric factors of radiation-induced esophageal injury: Radiation-induced esophageal toxicity. World J Gastroenterol. 2005;11:2626–2639
  7. Belderbos J, Heemsbergen W, Hoogeman M, et al. Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy. Radiother Oncol. 2005;75:157–164
  8. Patel AB, Edelman MJ, Kwok Y, et al. Predictors of acute esophagitis in patients with non-small-cell lung carcinoma treated with concurrent chemotherapy and hyperfractionated radiotherapy followed by surgery. Int J Radiat Oncol Biol Phys. 2004;60:1106–1112
  9. De Ruysscher D, Dehing C, Bremer R-H, et al. Maximal neutropenia during chemotherapy and radiotherapy is significantly associated with the development of acute radiation-induced dysphagia in lung cancer patients. Ann Oncol. 2007;18:909–916
  10. Hirota S, Tsujino K, Endo M, et al. Dosimetric predictors of radiation esophagitis in patients treated for non-small-cell lung cancer with carboplatin/paclitaxel/radiotherapy. Int J Radiat Oncol Biol Phys. 2001;51:291–295
  11. Bradley J, Deasy JO, Bentzen S, et al. Dosimetric correlates for acute esophagitis in patients treated with radiotherapy for lung carcinoma. Int J Radiat Oncol Biol Phys. 2004;58:1106–1113
  12. Wei ZX, Liu HH, Tucker SL, et al. Risk factors for acute esophagitis in non-small-cell lung cancer patients treated with concurrent chemotherapy and three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2006;66:100–107
  13. Kim TH, Cho KH, Pyo HR, et al. Dose-volumetric parameters of acute esophageal toxicity in patients with lung cancer treated with lung cancer treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol. 2005;62:995–1002
  14. Komaki R, Swann RS, Ettinger DS, et al. Phase I study of thoracic radiation dose escalation with concurrent chemotherapy for patients with limited small-cell lung cancer: Report of Radiation Therapy Oncology Group (RTOG) protocol 97-12. Int J Radiat Oncol Biol Phys. 2005;62:342–350
  15. De Ruysscher D, Bremer R-H, Koppe F, et al. Omission of elective node irradiation on basis of CT-scans in patients with limited disease small cell lung cancer: A phase II trial. Radiother Oncol. 2006;80:307
  16. Garces YI, Okuno SH, Schild SE, et al. Phase I North Central Cancer Treatment Group trial-N9923 of escalating doses of twice-daily thoracic radiation therapy with amifostine and with alternating chemotherapy in limited stage small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2007;67:995–1001
  17. Movsas B, Scott C, Langer C, et al. Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfractionated radiation: Radiation Therapy Oncology Group trial 98-01. J Clin Oncol. 2005;23:2145–2154
  18. Laurie AS, Logan D, Markman BR, et al. Practice guideline for the role of combination chemotherapy in the initial management of limited-stage small-cell lung cancer. Lung Cancer. 2004;43:223–240
  19. Hallqvist A, Rylander H, Bjork-Eriksson T, et al. Accelerated hyperfractionated radiotherapy and concomitant chemotherapy in small cell lung cancer limited-disease. Dose response, feasibility and outcome for patients treated in western Sweden, 1998-2004. Acta Oncol. 2007;46:969–974

 Supported with resources and the use of facilities at the Ralph H. Johnson Veterans' Affairs Medical Center, Charleston, South Carolina.

 Presented at the 90th Annual Meeting of the American Radium Society, Laguna Niguel, California, May 3, 2008.

 Conflict of interest: none.

PII: S0360-3016(08)03465-2

doi: 10.1016/j.ijrobp.2008.09.013

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 4 , Pages 1108-1113 , 15 July 2009

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