International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 3 , Pages 723-731 , 1 July 2009

Stereotactic Body Radiotherapy Is Effective Salvage Therapy for Patients With Prior Radiation of Spinal Metastases

  • Arjun Sahgal, M.D.

      Affiliations

    • Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
    • Department of Radiation Oncology, University of Toronto, Sunnybrook Odette Cancer Centre and the Princess Margaret Hospital, Toronto, ON, Canada
    • Corresponding Author InformationReprint requests to: Dr. Arjun Sahgal, Department of Radiation Oncology, University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada. Tel: (416) 946-2131; Fax: (416) 480-6002
  • ,
  • Christopher Ames, M.D.

      Affiliations

    • Department of Neurologic Surgery, University of California San Francisco, San Francisco, CA
  • ,
  • Dean Chou, M.D.

      Affiliations

    • Department of Neurologic Surgery, University of California San Francisco, San Francisco, CA
  • ,
  • Lijun Ma, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
  • ,
  • Kim Huang, M.D.

      Affiliations

    • Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
  • ,
  • Wei Xu, Ph.D.

      Affiliations

    • Department of Epidemiology, University of Toronto, Princess Margaret Hospital, Toronto, ON, Canada
  • ,
  • Cynthia Chin, M.D.

      Affiliations

    • Department of Radiology, University of California San Francisco, San Francisco, CA
  • ,
  • Vivan Weinberg, Ph.D.

      Affiliations

    • UCSF Helen Diller Family Comprehensive Cancer Center Biostatistics Core, University of California San Francisco, San Francisco, CA
  • ,
  • Cynthia Chuang, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
  • ,
  • Phillip Weinstein, M.D.

      Affiliations

    • Department of Neurologic Surgery, University of California San Francisco, San Francisco, CA
  • ,
  • David A. Larson, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of California San Francisco, San Francisco, CA

Received 4 July 2008 ,Revised 13 September 2008 ,Accepted 23 September 2008.

References 

  1. Sahgal A, Larson DA, Chang EL. Stereotactic body radiosurgery for spinal metastases: A critical review. Int J Radiat Oncol Biol Phys. 2008;71:652–665
  2. Timmerman RD, Kavanagh BD, Cho LC, et al. Stereotactic body radiation therapy in multiple organ sites. J Clin Oncol. 2007;25:947–952
  3. Chang EL, Shiu AS, Mendel E, et al. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007;7:151–160
  4. Gerszten PC, Burton SA, Ozhasoglu C, et al. Radiosurgery for spinal metastases: Clinical experience in 500 cases from a single institution. Spine. 2007;32:193–199
  5. Gibbs IC, Kamnerdsupaphon P, Ryu MR, et al. Image-guided robotic radiosurgery for spinal metastases. Radiother Oncol. 2007;82:185–190
  6. Ryu S, Rock J, Rosenblum M, et al. Patterns of failure after single-dose radiosurgery for spinal metastasis. J Neurosurg. 2004;101(Suppl 3):402–405
  7. Sahgal A, Chou D, Ames C, et al. Image-guided robotic stereotactic body radiotherapy for benign spinal tumors: The University of California San Francisco preliminary experience. Technol Cancer Res Treat. 2007;6:595–604
  8. Yamada Y, Bilsky MH, Lovelock DM, et al. High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys. 2008;71:484–490
  9. Gerszten PC, Burton SA, Ozhasoglu C. CyberKnife radiosurgery for spinal neoplasms. Prog Neurol Surg. 2007;20:340–358
  10. Gerszten PC, Burton SA. Clinical Assessment Of Stereotactic IGRT: Spinal Radiosurgery. Med Dosim. 2008;33:107–116
  11. Guckenberger M, Meyer J, Wilbert J, et al. Precision required for dose-escalated treatment of spinal metastases and implications for image-guided radiation therapy (IGRT). Radiother Oncol. 2007;84:56–63
  12. Ho AK, Fu D, Cotrutz C, et al. A study of the accuracy of cyberknife spinal radiosurgery using skeletal structure tracking. Neurosurgery. 2007;60:ONS147–ONS156discussion ONS156
  13. Chuang C, Sahgal A, Lee L, et al. Effects of residual target motion for image-tracked spine radiosurgery. Med Phys. 2007;34:4484–4490
  14. Sherry MM, Greco FA, Johnson DH, et al. Metastatic breast cancer confined to the skeletal system. An indolent disease. Am J Med. 1986;81:381–386
  15. Hortobagyi GN, Smith TL, Legha SS, et al. Multivariate analysis of prognostic factors in metastatic breast cancer. J Clin Oncol. 1983;1:776–786
  16. Porter GJ, Evans AJ, Pinder SE, et al. Patterns of metastatic breast carcinoma: Influence of tumour histological grade. Clin Radiol. 2004;59:1094–1098
  17. Rades D, Veninga T, Stalpers LJ, et al. Outcome after radiotherapy alone for metastatic spinal cord compression in patients with oligometastases. J Clin Oncol. 2007;25:50–56
  18. Ryu S, Jin JY, Jin R, et al. Partial volume tolerance of the spinal cord and complications of single-dose radiosurgery. Cancer. 2007;109:628–636
  19. Chow E, Harris K, Fan G, et al. Palliative radiotherapy trials for bone metastases: A systematic review. J Clin Oncol. 2007;25:1423–1436
  20. Hamilton AJ, Lulu BA, Fosmire H, et al. Preliminary clinical experience with linear accelerator-based spinal stereotactic radiosurgery. Neurosurgery. 1995;36:311–319
  21. Chow E, Wu JS, Hoskin P, et al. International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol. 2002;64:275–280
  22. Gagnon GJ, Henderson FC, Gehan EA, et al. Cyberknife radiosurgery for breast cancer spine metastases: A matched-pair analysis. Cancer. 2007;110:1796–1802
  23. Guerrero M, Li XA. Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy. Phys Med Biol. 2004;49:4825–4835
  24. Dodd RL, Ryu MR, Kamnerdsupaphon P, et al. CyberKnife radiosurgery for benign intradural extramedullary spinal tumors. Neurosurgery. 2006;58:674–685discussion 674–685
  25. Gwak HS, Yoo HJ, Youn SM, et al. Hypofractionated stereotactic radiation therapy for skull base and upper cervical chordoma and chondrosarcoma: Preliminary results. Stereotact Funct Neurosurg. 2005;83:233–243
  26. Gerszten PC, Burton SA, Ozhasoglu C, et al. Radiosurgery for benign intradural spinal tumors. Neurosurgery. 2008;62:887–895discussion 895–886
  27. Sahgal A, Gibbs I, Ryu S, et al. Preliminary Guidelines for Avoidance of Radiation Indicued Myelopathy Sollowing Spine Stereotactic Body Radiosurgery (SBRS). Int J Radiat Oncol Biol Phys. 2008;72:S220

 Conflict of interest: none.

PII: S0360-3016(08)03500-1

doi: 10.1016/j.ijrobp.2008.09.020

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 3 , Pages 723-731 , 1 July 2009