International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 3 , Pages 714-722 , 1 July 2009

Target Definition by C11-Methionine-PET for the Radiotherapy of Brain Metastases

  • Masayuki Matsuo, M.D.

      Affiliations

    • Department of Radiation Oncology, Chubu Medical Centre for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo, Japan
    • Corresponding Author InformationReprint requests to: Masayuki Matsuo, M.D., Department of Radiation Oncology, Kizawa Memorial Hospital, 590 Shimokobi, Minokamo 505–8503, Japan. Fax: (+81) 574-25-2181; Phone: (+81) 574-26-2181
    • ,
  • Kazuhiro Miwa, M.D.

      Affiliations

    • Department of Neurosurgery, Chubu Medical Centre for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo, Japan
    • ,
  • Jun Shinoda, M.D.

      Affiliations

    • Department of Neurosurgery, Chubu Medical Centre for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo, Japan
    • ,
  • Nobuo Kako, M.D.

      Affiliations

    • Department of Radiology, Kizawa Memorial Hospital, Minokamo, Japan
    • ,
  • Hironori Nishibori, M.D.

      Affiliations

    • Department of Radiology, Kizawa Memorial Hospital, Minokamo, Japan
    • ,
  • Kouta Sakurai, M.D.

      Affiliations

    • Department of Radiology, Kizawa Memorial Hospital, Minokamo, Japan
    • ,
  • Hirohito Yano, M.D.

      Affiliations

    • Department of Neurosurgery, Gifu University School of Medicine, Gifu, Japan
    • ,
  • Toru Iwama, M.D.

      Affiliations

    • Department of Neurosurgery, Gifu University School of Medicine, Gifu, Japan
    • ,
  • Masayuki Kanematsu, M.D.

      Affiliations

    • Department of Radiology, Gifu University School of Medicine, Gifu, Japan

Received 2 April 2008 ,Accepted 26 August 2008.

References 

  1. Posner JB. Management of brain metastasis. Rev Neurol. 1992;148:477–487
  2. Breneman JC, Warnick RE, Albright RE, et al. Stereotactic radiosurgery for the treatment of brain metastases. Cancer. 1997;79:551–557
  3. Flickinger JC, Kondziolka D, Lunsford LD, et al. A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys. 1994;28:797–802
  4. Engenhart R, Kimmig BN, Hover K, et al. Long-term follow-up for brain metastases treated by percutaneous single high-dose radiation. Cancer. 1993;71:1353–1361
  5. Feuvret L, Germain I, Cornu P, et al. Traitement premier des metastases cerebrales par irradiation en condition stereotaxique. [First treatment for brain metastases by stereotactic radiosurgery]. Bull Cancer. 1999;86:666–671
  6. Pirzkall A, Debus J, Lohr F, et al. Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastasis. J Clin Oncol. 1998;16:3663–3669
  7. Brigitta G, Baumert , Isabelle Rutten , et al. A pathology-based substrate for target definition in radiosurgery of brain metastases. Int J Radiat Oncol Biol Phys. 2006;66:187–194
  8. Di Chiro G, DeLaPaz RL, Brooks RA, et al. Glucose utilization of cerebral gliomas measured by [18F]fluorodeoxyglucose and positron emission tomography. Neurology. 1982;32:1323–1329
  9. Patronas NJ, Brooks RA, DeLaPaz RL, et al. Glycolytic rate (PET) and contrast enhancement (CT) in human cerebral gliomas. Am J Nucl Res. 1983;4:533–535
  10. Bergstrom M, Collins VP, Ehrin E, et al. Discrepancies in brain tumor extent as shown by computed tomography and positron emission tomography using [68Ga] EDTA [11C] glucose, and [11C] methionine. J Comput Assist Tomogr. 1983;7:1062–1066
  11. Ogawa T, Kanno I, Shishido F, et al. Clinical value of PET with 18F-fluorodeoxyglucose and L-methyl-11C-methionine for diagnosis of recurrent brain tumor and radiation injury. Acta Radiol. 1991;21:198–202
  12. Mosskin M, Ericson K, Hindmarsh T, et al. Positron emission tomography compared with magnetic resonance imaging and computed tomography in supratentorial gliomas using multiple stereotactic biopsies as reference. Acta Radiol. 1989;30:225–232
  13. Miwa K, Shinoda J, Yano H, et al. Discrepancy between lesion distributions on methionine PET and MR images in patients with glioblastoma multiforme: Insight from a PET and MR fusion image study. J Neurol Neurosurg Psychiatry. 2004;75:1457–1462
  14. Braun V, Dempf S, Weller R, et al. Cranial neuronavigation with direct integration of (11)C methionine positron emission tomography (PET) data—Results of a pilot study in 32 surgical cases. Acta Neurochir (Wien). 2002;144:777–782
  15. Kaschten B, Stevenaert A, Sadzot B, et al. Preoperative evaluation of 54 gliomas by PET with fluorine-18-fluorodeoxyglucose and/or carbon-11-methionine. J Nucl Med. 1998;39:778–785
  16. Herholz K, Holzer T, Bauer B, et al. 11C-methionine PET for differential diagnosis of low-grade gliomas. Neurology. 1998;50:1316–1322
  17. Davis PC, Hudgins PA, Peterman SB, et al. Diagnosis of cerebral metastases: Double-dose delayed CT vs contrast-enhanced MR imaging. AJNR. 1991;12:293–300
  18. Breneman JC, Warnick RE, Albright RE, et al. Stereotactic radiosurgery for the treatment of brain metastases. Cancer. 1997;79:551–557
  19. Flickinger JC, Kondziolka D, Lunsford LD, et al. A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys. 1994;28:797–802
  20. Engenhart R, Kimmig BN, Hover K, et al. Long-term follow-up for brain metastases treated by percutaneous single high-dose radiation. Cancer. 1993;71:1353–1361
  21. Feuvret L, Germain I, Cornu P, et al. Traitement premier des metastases cerebrales par irradiation en condition stereotaxique. [First treatment for brain metastases by stereotactic radiosurgery]. Bull Cancer. 1999;86:666–671
  22. Pirzkall A, Debus J, Lohr F, et al. Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastasis. J Clin Oncol. 1998;16:3663–3669
  23. Noel G, Simon JM, Valery CA, et al. Radiosurgery for brain metastasis (Impact of CTV on local control). Radiother Oncol. 2003;68:15–21
  24. Kracht LW, Miletic H, Busch S, et al. Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: Local comparison with stereotactic histopathology. Clin Cancer Res. 2004;10:7163–7170
  25. Mahasittiwat P, Mizoe JE, Hasegawa A, et al. l-[METHYL-(11)C] methionine positron emission tomography for target delineation in malignant gliomas: Impact on results of carbon ion radiotherapy. Int J Radiat Oncol Biol Phys. 2008;70:515–522
  26. Thompson CJ, St James S, Tomic N. Under-sampling in PET scanners as a source of blurring. Nucl Instrum Meth Phys Res A. 2005;545:436–445
  27. Grosu A-L, Lachner R, Wiedenmann N, et al. Validation of a method for automatic image fusion (BrainLAB System) of CT data and 11C-methionine-PET data for stereotactic radiotherapy using a LINAC: First clinical experience. Int J Radiat Oncol Biol Phys. 2003;56:1450–1463

 Parts of this article were presented at 49th Annual Meeting of American Society for Therapeutic Radiation Oncology (ASTRO), October 28–November 1, 2007, Los Angeles, CA.

 Conflicts of interest: none

PII: S0360-3016(08)03506-2

doi: 10.1016/j.ijrobp.2008.08.056

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 3 , Pages 714-722 , 1 July 2009

Article Tools

* Image Usage & Resolution