International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 4 , Pages 1100-1107 , 15 July 2009

Tumor Localization Using Cone-Beam CT Reduces Setup Margins in Conventionally Fractionated Radiotherapy for Lung Tumors

  • Anamaria R. Yeung, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
  • ,
  • Jonathan G. Li, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
  • ,
  • Wenyin Shi, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
  • ,
  • Heather E. Newlin, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
  • ,
  • Alexei Chvetsov, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
  • ,
  • Chihray Liu, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
  • ,
  • Jatinder R. Palta, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
  • ,
  • Kenneth Olivier, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL
    • Corresponding Author InformationReprint requests to: Kenneth Olivier, M.D., Department of Radiation Oncology, Mayo Clinic, Charlton Building, Desk R, 200 First St. S.W., Rochester, MN 55905. Tel: (507) 284-2511.

Received 2 June 2008 ,Revised 15 August 2008 ,Accepted 26 September 2008.

References 

  1. Schallenkamp JM, Herman MG, Kruse JJ, et al. Prostate position relative to pelvic bony anatomy based on intraprostatic gold markers and electronic portal imaging. Int J Radiat Oncol Biol Phys. 2005;63:800–811
  2. Kupelian PA, Lee C, Langen KM, et al. Evaluation of image-guidance strategies in the treatment of localized prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70:1151–1157
  3. De Crevoisier R, Tucker SL, Dong L, et al. Increased risk of biochemical and local failure in patients with distended rectum on the planning CT for prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:965–973
  4. Heemsbergen WD, Hoogeman MS, Witte MG, et al. Increased risk of biochemical and clinical failure for prostate patients with a large rectum at radiotherapy planning: Results from the Dutch trial of 68 Gy versus 78 Gy. Int J Radiat Oncol Biol Phys. 2007;67:1418–1424
  5. Kupelian PA, Willoughby TR, Reddy CA, et al. Impact of image guidance on outcomes after external beam radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70:1146–1150
  6. Ghilezan M, Yan D, Liang J, et al. Online image-guided intensity-modulated radiotherapy for prostate cancer: How much improvement can we expect? A theoretical assessment of clinical benefits and potential dose escalation by improving precision and accuracy of radiation delivery. Int J Radiat Oncol Biol Phys. 2004;60:1602–1610
  7. Cox JD, Azarnia N, Byhardt RW, et al. A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: Possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non–small-cell lung carcinoma: Report of Radiation Therapy Oncology Group 83-11. J Clin Oncol. 1990;8:1543–1555
  8. Rengan R, Rosenzweig KE, Venkatraman E, et al. Improved local control with higher doses of radiation in large-volume stage III non–small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2004;60:741–747
  9. Narayan S, Henning GT, Ten Haken RK, et al. Results following treatment to doses of 92.4 or 102.9 Gy on a phase I dose escalation study for non-small cell lung cancer. Lung Cancer. 2004;44:79–88
  10. Onishi H, Araki T, Shirato H, et al. Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: Clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer. 2004;101:1623–1631
  11. Grills IS, Hugo G, Kestin LL, et al. Image-guided radiotherapy via daily online cone-beam CT substantially reduces margin requirements for stereotactic lung radiotherapy. Int J Radiat Oncol Biol Phys. 2008;70:1045–1056
  12. Purdie TG, Bissonnette JP, Franks K, et al. Cone-beam computed tomography for on-line image guidance of lung stereotactic radiotherapy: Localization, verification, and intrafraction tumor position. Int J Radiat Oncol Biol Phys. 2007;68:243–252
  13. Borgefors G. Hierarchical chamfer matching: A parametric edge matching algorithm. IEEE Trans Pattern Anal Mach Intell. 1988;10:849–865
  14. Hristov DH, Fallone BG. A grey-level image alignment algorithm for registration of portal images and digitally reconstructed radiographs. Med Phys. 1996;23:75–84
  15. van Herk M. Errors and margins in radiotherapy. Semin Radiat Oncol. 2004;14:52–64
  16. van Herk M, Remeijer P, Rasch C, et al. The probability of correct target dosage: Dose–population histograms for deriving treatment margins in radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47:1121–1135
  17. Guckenberger M, Meyer J, Vordermark D, et al. Magnitude and clinical relevance of translational and rotational patient setup errors: A cone-beam CT study. Int J Radiat Oncol Biol Phys. 2006;65:934–942
  18. Borst GR, Sonke JJ, Betgen A, et al. Kilo-voltage cone-beam computed tomography setup measurements for lung cancer patients: First clinical results and comparison with electronic portal-imaging device. Int J Radiat Oncol Biol Phys. 2007;68:555–561
  19. Guckenberger M, Meyer J, Wilbert J, et al. Cone-beam CT based image-guidance for extracranial stereotactic radiotherapy of intrapulmonary tumors. Acta Oncol. 2006;45:897–906
  20. Wang L, Feigenberg S, Chen L, et al. Benefit of three-dimensional image-guided stereotactic localization in the hypofractionated treatment of lung cancer. Int J Radiat Oncol Biol Phys. 2006;66:738–747
  21. Harsolia A, Hugo GD, Kestin LL, et al. Dosimetric advantages of four-dimensional adaptive image-guided radiotherapy for lung tumors using online cone-beam computed tomography. Int J Radiat Oncol Biol Phys. 2008;70:582–589
  22. Brenner DJ, Hall EJ. Computed tomography—An increasing source of radiation exposure. N Engl J Med. 2007;357:2277–2284

 Conflict of interest: the authors' department received a grant from Elekta that pays 20% of A. Chvetsov's salary.

PII: S0360-3016(08)03558-X

doi: 10.1016/j.ijrobp.2008.09.048

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 4 , Pages 1100-1107 , 15 July 2009