International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 5 , Pages 1555-1562 , 1 August 2009

The AMORE Protocol for Advanced-Stage and Recurrent Nonorbital Rhabdomyosarcoma in the Head-and-Neck Region of Children: A Radiation Oncology View

  • Leo E.C.M. Blank, M.D.

      Affiliations

    • Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Kees Koedooder, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Bradley R. Pieters, M.D.

      Affiliations

    • Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Hans N.B. van der Grient

      Affiliations

    • Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Marlou van de Kar

      Affiliations

    • Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Joeri Buwalda, M.D, Ph.D.

      Affiliations

    • Department of ENT, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Alfons J.M. Balm, M.D., Ph.D.

      Affiliations

    • Department of ENT, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Johannes H.M. Merks, M.D., Ph.D.

      Affiliations

    • Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Simon D. Strackee, M.D., Ph.D.

      Affiliations

    • Department of Plastic and Reconstructive Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Nicole J. Freling, M.D., Ph.D.

      Affiliations

    • Department of Diagnostic Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Caro C.E. Koning, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests to: Caro C. E. Koning, M.D., Ph.D., Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Postbox 22660, 1100 DD Amsterdam, The Netherlands. Tel: (+31) +20-566-3750; Fax: (+31) +20-609-1278

Received 10 July 2008 ,Revised 7 October 2008 ,Accepted 8 October 2008.

References 

  1. McDowell HP. Update on childhood rhabdomyosarcoma. Arch Dis Child. 2003;88:354–357
  2. Miller RW, Young JL, Novakovic B. Childhood cancer. Cancer. 1995;75(Suppl.):S395–S405
  3. Young JL, Ries LG, Silverberg E, et al. Cancer incidence, survival, and mortality for children younger than age 15 years. Cancer. 1986;58(Suppl.):S598–S602
  4. Crist WM, Garnsey L, Beltangady MS, et al. Prognosis in children with rhabdomyosarcoma: A report of the Intergroup Rhabdomyosarcoma Studies I and II. Intergroup Rhabdomyosarcoma Committee. J Clin Oncol. 1990;8:443–452
  5. Harmer MH. TNM classification of pediatric tumors. Geneva: International Union Against Cancer; 1982;p. 23–28
  6. Maurer HM. The Intergroup's Rhabdomyosarcoma Study: Objectives and clinical staging classification. J Pediatr Surg. 1975;10:977–978
  7. Pappo AS, Meza JL, Donaldson SS, et al. Treatment of localized nonorbital, nonparameningeal head and neck rhabdomyosarcoma: Lessons learned from Intergroup Rhabdomyosarcoma Studies III and IV. J Clin Oncol. 2003;21:638–645
  8. Raney RB, Tefft M, Newton WA, et al. Improved prognosis with intensive treatment of children with cranial soft tissue sarcomas arising in nonorbital parameningeal sites. A report from the Intergroup Rhabdomyosarcoma Study. Cancer. 1987;59:147–155
  9. Paulino AC. Role of radiation therapy in parameningeal rhabdomyosarcoma. Cancer Invest. 1999;17:223–230
  10. Raney RB, Meza J, Anderson JR, et al. Treatment of children and adolescents with localized parameningeal sarcoma: Experience of the Intergroup Rhabdomyosarcoma Study Group protocols IRS-II through -IV, 1978-1997. Med Pediatr Oncol. 2002;38:22–32
  11. Stevens MC, Rey A, Bouvet N, et al. Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: Third study of the International Society of Paediatric Oncology—SIOP Malignant Mesenchymal Tumor 89. J Clin Oncol. 2005;23:2618–2628
  12. Denys D, Kaste SC, Kun LE, et al. The effects of radiation on craniofacial skeletal growth: A quantitative study. Int J Pediatr Otorhinolaryngol. 1998;45:7–13
  13. Pappo AS, Anderson JR, Crist WM, et al. Survival after relapse in children and adolescents with rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study Group. J Clin Oncol. 1999;17:3487–3493
  14. Raney RB, Crist WM, Maurer HM, et al. Prognosis of children with soft tissue sarcoma who relapse after achieving a complete response. A report from the Intergroup Rhabdomyosarcoma Study I. Cancer. 1983;52:44–50
  15. Buwalda J, Schouwenburg PF, Blank LE, et al. A novel local treatment strategy for advanced stage head and neck rhabdomyosarcomas in children: Results of the AMORE protocol. Eur J Cancer. 2003;39:1594–1602
  16. Buwalda J, Blank LE, Schouwenburg PF, et al. The AMORE protocol as salvage treatment for non-orbital head and neck rhabdomyosarcoma in children. Eur J Surg Oncol. 2004;30:884–892
  17. Buwalda J. AMORE for childhood head and neck rhabdomyosarcoma. Ph.D. Thesis, University of Amsterdam, Amsterdam, The Netherlands, 2004.
  18. Buwalda J, Freling NJ, Blank LE, et al. AMORE protocol in pediatric head and neck rhabdomyosarcoma: Descriptive analysis of failure patterns. Head Neck. 2005;27:390–396
  19. Koedooder K, van Wieringen N, van der Grient HN, et al. Safety aspects of pulsed dose rate brachytherapy: Analysis of errors in 1,300 treatment sessions. Int J Radiat Oncol Biol Phys. 2008;70:953–960
  20. Koscielniak E, Harms D, Henze G, et al. Results of treatment for soft tissue sarcoma in childhood and adolescence: A final report of the German Cooperative Soft Tissue Sarcoma Study CWS-86. J Clin Oncol. 1999;17:3706–3719
  21. Paulino AC, Simon JH, Zhen W, et al. Long-term effects in children treated with radiotherapy for head and neck rhabdomyosarcoma. Int J Radiat Oncol Biol Phys. 2000;48:1489–1495
  22. Raney RB, Asmar L, Vassilopoulou-Sellin R, et al. Late complications of therapy in 213 children with localized, nonorbital soft-tissue sarcoma of the head and neck: A descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS)-II and - III. IRS Group of the Children's Cancer Group and the Pediatric Oncology Group. Med Pediatr Oncol. 1999;33:362–371
  23. Geenen MM, Cardous-Ubbink MC, Kremer LC, et al. Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA. 2007;297:2705–2715
  24. Chen C, Shu HG, Goldwein J, et al. Volumetric considerations in radiotherapy for pediatric parameningeal rhabdomyosarcomas. Int J Radiat Oncol Biol Phys. 2003;55:1294–1299

 Conflict of interest: none.

PII: S0360-3016(08)03667-5

doi: 10.1016/j.ijrobp.2008.10.029

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 5 , Pages 1555-1562 , 1 August 2009

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