International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 3 , Pages 904-912, 1 March 2009

A Systematic Assessment of Radiation Dose Enhancement by 5-Aza-2′-Deoxycytidine and Histone Deacetylase Inhibitors in Head-and-Neck Squamous Cell Carcinoma

  • Harlinde De Schutter, M.D.

      Affiliations

    • Laboratory of Experimental Radiotherapy, Leuvens Kanker Instituut, University Hospitals Leuven, Leuven, Belgium
    • ,
  • Marlies Kimpe, M.Sc.

      Affiliations

    • Laboratory of Experimental Radiotherapy, Leuvens Kanker Instituut, University Hospitals Leuven, Leuven, Belgium
    • ,
  • Sofie Isebaert, M.Sc.

      Affiliations

    • Laboratory of Experimental Radiotherapy, Leuvens Kanker Instituut, University Hospitals Leuven, Leuven, Belgium
    • ,
  • Sandra Nuyts, M.D., Ph.D.

      Affiliations

    • Laboratory of Experimental Radiotherapy, Leuvens Kanker Instituut, University Hospitals Leuven, Leuven, Belgium
    • Department of Radiation Oncology, Leuvens Kanker Instituut, University Hospitals Leuven, Leuven, Belgium
    • Corresponding Author InformationReprint requests to: Sandra Nuyts, M.D., Ph.D., Department of Radiation Oncology, UH Leuven–Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. Tel: (0032) 16-34-7600; Fax: (0032) 16-34-6905

Received 24 June 2008; received in revised form 20 October 2008; accepted 23 October 2008.

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 Presented at the 7th International Conference on Head and Neck Cancer (American Head and Neck Society Meeting), San Francisco, CA, July 19–23, 2008.

 Supported by the Fonds voor Wetenschappelijk Onderzoek–Vlaanderen, the Vlaamse Liga tegen Kanker, and the Klinisch OnderzoeksFonds. LBH589 was provided by Novartis, and MGCD0103 was provided by MethylGene.

 Conflict of interest: none.

PII: S0360-3016(08)03674-2

doi:10.1016/j.ijrobp.2008.10.032

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 3 , Pages 904-912, 1 March 2009

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