International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 1 , Pages 76-81 , 1 September 2009

Breast-Conserving Treatment in the Elderly: Long-Term Results of Adjuvant Hypofractionated and Normofractionated Radiotherapy

  • Youlia M. Kirova, M.D.

      Affiliations

    • Department of Radiation Oncology, Institut Curie, Paris, France
    • Corresponding Author InformationReprint requests to: Youlia M. Kirova, M.D., Department of Radiation Oncology, Institut Curie, 26, Rue d'Ulm, Paris 75005 France. Tel: (331) 4432-4637; Fax: (331) 4432-4616
    • ,
  • Francois Campana, M.D.

      Affiliations

    • Department of Radiation Oncology, Institut Curie, Paris, France
    • ,
  • Alexia Savignoni, M.D.

      Affiliations

    • Department of Statistics, Institut Curie, Paris, France
    • ,
  • Fatima Laki, M.D.

      Affiliations

    • Department of Surgery, Institut Curie, Paris, France
    • ,
  • Marius Muresan, M.D.

      Affiliations

    • Department of Radiation Oncology, Institut Curie, Paris, France
    • ,
  • Remi Dendale, M.D.

      Affiliations

    • Department of Radiation Oncology, Institut Curie, Paris, France
    • ,
  • Marc A. Bollet, M.D.

      Affiliations

    • Department of Radiation Oncology, Institut Curie, Paris, France
    • ,
  • Remy J. Salmon, M.D.

      Affiliations

    • Department of Surgery, Institut Curie, Paris, France
    • ,
  • Alain Fourquet, M.D.

      Affiliations

    • Department of Radiation Oncology, Institut Curie, Paris, France
    • ,
  • Institut Curie Breast Cancer Study Group

Received 6 August 2008 ,Revised 30 October 2008 ,Accepted 4 November 2008.

References 

  1. Wildiers H, Kunkler I, Biganzoli L, et al. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. Lancet Oncol. 2007;8:1101–1115
  2. Maher M, Campana F, Mosseri V, et al. Breast cancer in elderly women: A retrospective analysis of combined treatment with tamoxifen and once-weekly irradiation. Int J Radiat Oncol Biol Phys. 1995;31:783–789
  3. Diab SG, Elledge RM, Clark GM, et al. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst. 2000;92:550–556
  4. Pierga JY, Girre V, Laurence V, et al. Characteristics and outcome of 1755 operable breast cancers in women over 70 years of age. Breast. 2004;13:369–375
  5. Ortholan C, Hannoun-Lévi JM, Ferrero JM, et al. Long-term results of adjuvant hypofractionated radiotherapy for breast cancer in elderly patients. Int J Radiat Oncol Biol Phys. 2005;61:154–162
  6. Cutuli B, Aristei C, Martin C, et al. Breast-conserving therapy for stage I-II breast cancer in elderly women. Int J Radiat Oncol Biol Phys. 2004;60:71–76
  7. Yancik R, Wesley MN, Ries LA, et al. Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. JAMA. 2001;285:885–892
  8. Gazet JC, Markopoulos C, Ford HT, et al. Prospective randomised trial of tamoxifen versus surgery in elderly patients with breast cancer. Lancet. 1988;1:679–681
  9. Hughes KS, Schnaper LA, Berry D, et al. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med. 2004;351:971–977
  10. International Commission on Radiation Units and Measurements. ICRU report 50 and ICRU report 62 (supplement to ICRU report 50): Prescribing, recording and reporting photon beam therapy. Bethesda: ICRU; 1999;
  11. Campana F, Kirova YM, Rosenwald JC, et al. Breast radiotherapy in the lateral decubitus position—A technique to prevent lung and heart irradiation. Int J Radiat Oncol Biol Phys. 2005;61:1348–1354
  12. Kirova Y, Servois V, Campana F, et al. CT-scan based localization of the internal mammary chain and supra clavicular nodes for breast cancer radiation therapy planning. Radiother Oncol. 2006;79:310–315
  13. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  14. Cox DR. Regression models and life tables (with discussion). J Stat Soc B. 1972;34:187–220
  15. Bentzen SM, Agrawal RK, Aird EG, et al. for the START Trialists' Group The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet. 2008;371:1098–1107
  16. Bentzen SM, Agrawal RK, Aird AG, et al. for the START Trialists' Group The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet Oncol. 2008;9:331–341
  17. Whelan T, MacKenzie R, Julian J, et al. Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst. 2002;94:1143–1150
  18. Merchant TE, McCormick B. Prone position breast irradiation. Int J Radiat Oncol Biol Phys. 1994;30:197–203
  19. Buchholz TA, Kuerer HM, Strom EA. Is partial breast irradiation a step forward or backward?. Semin Radiat Oncol. 2005;15:69–75

 Presented as an oral presentation at the 50th American Society for Therapeutic Radiology and Oncology Annual Meeting, September 21–25, 2008, Boston, MA.

 Conflict of interest: none.

PII: S0360-3016(08)03730-9

doi: 10.1016/j.ijrobp.2008.11.005

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 1 , Pages 76-81 , 1 September 2009

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