Effect of Family History on Outcomes in Patients Treated With Definitive Brachytherapy for Clinically Localized Prostate CancerPage 24
C. A. Peters, R. G. Stock, S. R. Blacksburg, and N. N. Stone
In this first study of the effect of a family history of prostate cancer on outcome in patients treated with brachytherapy alone or in combination with other therapy, the authors examined 187 consecutive patients with such a history out of a total patient population of 1,738 men. Freedom from biochemical failure (FFBF) was the primary endpoint. The 5-year FFBF rate in the men with a family history versus that in men without a family history was 97.2% vs. 95.5%, 100% vs. 93.6%, and 92.8% vs. 85.2% in the low-, medium-, and high-risk groups, respectively. Multivariate analysis showed that family history was not a significant factor in determining outcome from treatment in these men.
Concurrent Chemoradiotherapy in Resected Extrahepatic CholangiocarcinomaPage 148
J. W. Nelson, A. P. Ghafoori, C. G. Willett, D. S. Tyler, T. N. Pappas, B. M. Clary, H. I. Hurwitz, J. C. Bendell, M. A. Morse, R. W. Clough, and B. G. Czito
This study reviewed the Duke University experience with the use of radiation therapy either before or after the resection of extrahepatic bile duct tumors. The use of radiation in this setting is rational given that locoregional recurrence is common following surgery and is generally incurable. Our results suggest the addition of radiation therapy to surgery improves locoregional disease control rates and possibly survival rates compared to surgery alone. Additionally, similar to findings for other gastrointestinal malignancies, our study suggests that preoperative radiotherapy results in improved treatment-related outcomes without a corresponding increase in surgical morbidity relative to postoperative therapy. Distant disease failure remains a dominant pattern of relapse, suggesting the need for more effective systemic therapies.
Clinical Experience With Radiation Therapy in the Management of Neurofibromatosis-Associated Central Nervous System TumorsPage 208
S. Wentworth, M. Pinn, J. D. Bourland, A. F. deGuzman, K. Ekstrand, T. L. Ellis, S. S. Glazier, K. P. McMullen, M. Munley, V. W. Stieber, S. B. Tatter, and E. G. Shaw
These authors examined the treatment of central nervous system (CNS) tumors in patients with neurofibromatosis (NF). Patients were treated with stereotactic radiosurgery or external-beam radiation therapy for benign and malignant tumors such as meningiomas and low-grade gliomas. Excellent local control rates and clinical outcomes were found that were similar to those achieved in non-NF patients. This study supports the consideration of radiotherapy in the management of NF patients with CNS tumors.
Clinical Evaluation of Positioning Verification Using Digital Tomosynthesis and Bony Anatomy and Soft Tissues for Prostate Image–Guided RadiotherapyPage 296
S. Yoo, Q. J. Wu, D. Godfrey, H. Yan, L. Ren, S. Das, W. R. Lee, and F.-F. Yin
Digital tomosynthesis (DTS) is a method for reconstructing and visualizing images in 3D from 2D cone-beam X-ray projection data acquired with a limited angle (∼40 degrees). In this study, the authors compared the positioning accuracy of the prostate cancer radiotherapy setup between DTS and CBCT, which involves a much greater imaging dose (360 degrees). DTS achieves accurate bony anatomy-based and soft tissue-based target localization comparable to that for CBCT for prostate radiotherapy, with the advantages of a faster scanning time and a lower imaging dose.
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