International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1252-1259 , 15 March 2009

Analysis of Salivary Flow and Dose–Volume Modeling of Complication Incidence in Patients With Head-and-Neck Cancer Receiving Intensity-Modulated Radiotherapy

  • Simona Marzi, Ph.D.

      Affiliations

    • Laboratorio di Fisica Medica e Sistemi Esperti, Istituto Regina Elena, Rome, Italy
    • Corresponding Author InformationReprint requests to: Simona Marzi, Ph.D., Laboratorio di Fisica Medica e Sistemi Esperti, Istituto Regina Elena, Viale Inigo Campioni 63, 00144 Roma, Italy. Tel: (+39) 652666971; Fax: (+39) 652662740
    • ,
  • Giuseppe Iaccarino, Ph.D.

      Affiliations

    • Laboratorio di Fisica Medica e Sistemi Esperti, Istituto Regina Elena, Rome, Italy
    • ,
  • Katia Pasciuti, Ph.D.

      Affiliations

    • Laboratorio di Fisica Medica e Sistemi Esperti, Istituto Regina Elena, Rome, Italy
    • ,
  • Antonella Soriani, Ph.D.

      Affiliations

    • Laboratorio di Fisica Medica e Sistemi Esperti, Istituto Regina Elena, Rome, Italy
    • ,
  • Marcello Benassi, Ph.D.

      Affiliations

    • Laboratorio di Fisica Medica e Sistemi Esperti, Istituto Regina Elena, Rome, Italy
    • ,
  • Giorgio Arcangeli, M.D.

      Affiliations

    • S.C. Radioterapia, Istituto Regina Elena, Rome, Italy
    • ,
  • Giuseppe Giovinazzo, M.D.

      Affiliations

    • S.C. Radioterapia, Istituto Regina Elena, Rome, Italy
    • ,
  • Michaela Benassi, M.D.

      Affiliations

    • S.C. Radioterapia, Istituto Regina Elena, Rome, Italy
    • ,
  • Laura Marucci, M.D.

      Affiliations

    • S.C. Radioterapia, Istituto Regina Elena, Rome, Italy

Received 5 August 2008 ,Revised 4 November 2008 ,Accepted 8 November 2008.

References 

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  2. Eisbruch A, Ten Haken RK, Kim HM, et al. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys. 1999;45:577–587
  3. Roesink JM, Moerland MA, Battermann JJ, et al. Quantitative dose-volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region. Int J Radiat Oncol Biol Phys. 2001;51:938–946
  4. Parliament MB, Scrimger RA, Anderson SG, et al. Preservation of oral health-related quality of life and salivary flow rates after inverse-planned intensity-modulated radiotherapy (IMRT) for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2004;58:663–673
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  7. Scrimger RA, Stavrev P, Parliament MB, et al. Phenomenologic model describing flow reduction for parotid gland irradiation with intensity-modulated radiotherapy: Evidence of significant recovery effect. Int J Radiat Oncol Biol Phys. 2004;60:178–185
  8. Blanco AI, Chao KSC, El Naqa I, et al. Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:1055–1069
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  14. Braam PM, Roesink JM, Moerland MA, et al. Long-term parotid gland function after radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:659–664
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  16. Eisbruch A, Kim HM, Terrell JE, et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;50:695–704
  17. Eisbruch A, Rhodus N, Rosenthal D, et al. How should we measure and report radiotherapy-induced xerostomia?. Semin Radiat Oncol. 2003;13:226–234
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  19. Al-Nawas B, Al-Nawas K, Kunkel M, et al. Quantifying radioxerostomia: Salivary flow rate, examiner's score, and quality of life questionnaire. Strahlenther Onkol. 2006;6:336–341
  20. Meiroviz A, Murdoch-Kinch CA, Schipper M, et al. Grading xerostomia by physicians or by patients after intensity-modulated radiotherapy of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2006;66:445–453
  21. Semenenko VA, Li XA. Lyman-Kutcher-Burman NTCP model parameters for radiation pneumonitis and xerostomia based on combined analysis of published clinical data. Phys Med Biol. 2008;53:737–755
  22. Schilstra C, Meertens H. Calculation of the uncertainty in complication probability for various dose-response models, applied to the parotid gland. Int J Radiat Oncol Biol Phys. 2001;50:147–158

 Conflict of interest: none.

PII: S0360-3016(08)03799-1

doi: 10.1016/j.ijrobp.2008.11.020

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1252-1259 , 15 March 2009

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