International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1235-1242 , 15 March 2009

Dosimetric Evaluation of Heterogeneity Corrections for RTOG 0236: Stereotactic Body Radiotherapy of Inoperable Stage I-II Non–Small-Cell Lung Cancer

  • Ying Xiao, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Jefferson Medical College, Philadelphia, PA
    • Corresponding Author InformationReprint requests to: Ying Xiao, Ph.D., Department of Radiation Oncology, Jefferson Medical College 111 South 11th St., Philadelphia, PA 19107. Tel: (215) 955-1632; Fax: (215) 955-0412
    • ,
  • Lech Papiez, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
    • ,
  • Rebecca Paulus, B.S.

      Affiliations

    • Radiation Therapy Oncology Group, Philadelphia, PA
    • ,
  • Robert Timmerman, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
    • ,
  • William L. Straube, M.S.

      Affiliations

    • Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO
    • ,
  • Walter R. Bosch, D.Sc.

      Affiliations

    • Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO
    • ,
  • Jeff Michalski, M.D.

      Affiliations

    • Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO
    • ,
  • James M. Galvin, D.Sc.

      Affiliations

    • Department of Radiation Oncology, Jefferson Medical College, Philadelphia, PA

Received 18 August 2008 ,Revised 11 November 2008 ,Accepted 13 November 2008.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43–66
  2. Jemal A, Tiwari RC, Murray T, et al. Cancer statistics, 2004. CA Cancer J Clin. 2004;54:8–29
  3. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106–130
  4. Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin. 2005;55:10–30
  5. Shields TW. Surgical therapy for carcinoma of the lung. Clin Chest Med. 1993;14:121–147
  6. Wilson DO, Weissfeld JL, Fuhrman CR, et al. The Pittsburgh lung screening study (PLuSS): Outcomes within 3 years of a first computed tomography scan. Am J Respir Crit Care Med. 2008;178:956–961
  7. Adebonojo SA, Bowser AN, Moritz DM, et al. Impact of revised stage classification of lung cancer on survival: A military experience. Chest. 1999;115:1507–1513
  8. Mountain CF. The international system for staging lung cancer. Semin Surg Oncol. 2000;18:106–115
  9. Naruke T, Goya T, Tsuchiya R, et al. Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg. 1988;96:440–447
  10. Coy P, Kennelly GM. The role of curative radiotherapy in the treatment of lung cancer. Cancer. 1980;45:698–702
  11. Haffty BG, Goldberg NB, Gerstley J, et al. Results of radical radiation therapy in clinical stage I, technically operable non–small-cell lung cancer. Int J Radiat Oncol Biol Phys. 1988;15:69–73
  12. Armstrong JG, Minsky BD. Radiation therapy for medically inoperable stage I and II non-small cell lung cancer. Cancer Treat Rev. 1989;16:247–255
  13. Dosoretz DE, Katin MJ, Blitzer PH, et al. Radiation therapy in the management of medically inoperable carcinoma of the lung: Results and implications for future treatment strategies. Int J Radiat Oncol Biol Phys. 1992;24:3–9
  14. Dosoretz DE, Galmarini D, Rubenstein JH, et al. Local control in medically inoperable lung cancer: An analysis of its importance in outcome and factors determining the probability of tumor eradication. Int J Radiat Oncol Biol Phys. 1993;27:507–516
  15. Kaskowitz L, Graham MV, Emami B, et al. Radiation therapy alone for stage I non–small-cell lung cancer. Int J Radiat Oncol Biol Phys. 1993;27:517–523
  16. Dosoretz DE, Katin MJ, Blitzer PH, et al. Medically inoperable lung carcinoma: The role of radiation therapy. Semin Radiat Oncol. 1996;6:98–104
  17. Curran WJ, Moldofsky PJ, Solin LJ. Analysis of the influence of elective nodal irradiation on postirradiation pulmonary function. Cancer. 1990;65:2488–2493
  18. Papiez L, Timmerman R. Hypofractionation in radiation therapy and its impact. Med Phys. 2008;35:112–118
  19. Bradley J, Graham MV, Winter K, et al. Toxicity and outcome results of RTOG 9311: A phase I–II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non–small-cell lung carcinoma. Int J Radiat Oncol Biol Phys. 2005;61:318–328
  20. Ding GX, Duggan DM, Lu B, et al. Impact of inhomogeneity corrections on dose coverage in the treatment of lung cancer using stereotactic body radiation therapy. Med Phys. 2007;34:2985–2994
  21. Matsuo Y, Takayama K, Nagata Y, et al. Interinstitutional variations in planning for stereotactic body radiation therapy for lung cancer. Int J Radiat Oncol Biol Phys. 2007;68:416–425
  22. Panettieri V, Wennberg B, Gagliardi G, et al. SBRT of lung tumours: Monte Carlo simulation with PENELOPE of dose distributions including respiratory motion and comparison with different treatment planning systems. Phys Med Biol. 2007;52:4265–4281
  23. Lax I, Panettieri V, Wennberg B, et al. Dose distributions in SBRT of lung tumors: Comparison between two different treatment planning algorithms and Monte-Carlo simulation including breathing motions. Acta Oncol. 2006;45:978–988
  24. Papiez L, Moskvin V, Timmerman R. The physics and dosimetry of stereotactic body radiation therapy. In:  Kavanagh BD,  Timmerman RD editor. Stereotactic body radiation therapy. Philadelphia: Lippincott Williams and Wilkins; 2005;p. 57–85
  25. Timmerman R, Galvin J, Michalski J, et al. Accreditation and quality assurance for radiation therapy oncology group: Multicenter clinical trials using stereotactic body radiation therapy in lung cancer. Acta Oncol. 2006;45:779–786
  26. Carrasco P, Jornet N, Duch MA, et al. Comparison of dose calculation algorithms in phantoms with lung equivalent heterogeneities under conditions of lateral electronic disequilibrium. Med Phys. 2004;31:2899–2911
  27. Vanderstraeten B, Reynaert N, Paelinck L, et al. Accuracy of patient dose calculation for lung IMRT: A comparison of Monte Carlo, convolution/superposition, and pencil beam computations. Med Phys. 2006;33:3149–3158
  28. Chang D, Liu C, Dempsey JF, et al. Predicting changes in dose distribution to tumor and normal tissue when correcting for heterogeneity in radiotherapy for lung cancer. Am J Clin Oncol. 2007;30:57–62
  29. Davidson SE, Ibbott GS, Prado KL, et al. Accuracy of two heterogeneity dose calculation algorithms for IMRT in treatment plans designed using an anthropomorphic thorax phantom. Med Phys. 2007;34:1850–1857
  30. Knoos T, Wieslander E, Cozzi L, et al. Comparison of dose calculation algorithms for treatment planning in external photon beam therapy for clinical situations. Phys Med Biol. 2006;51:5785–5807
  31. Papanikolaou N, Mackie TR, Meger-Wells C, et al. Investigation of the convolution method for polyenergetic spectra. Med Phys. 1993;20:1327–1336
  32. McNutt TR, Mackie TR, Reckwerdt P, et al. Modeling dose distributions from portal dose images using the convolution/superposition method. Med Phys. 1996;23:1381–1392
  33. Starkschall G, Steadham RE, Popple RA, et al. Beam-commissioning methodology for a three-dimensional convolution/superposition photon dose algorithm. J Appl Clin Med Phys. 2000;1:8–27
  34. Ahnesjo A. Collapsed cone convolution of radiant energy for photon dose calculation in heterogeneous media. Med Phys. 1989;16:577–592
  35. Miften M, Wiesmeyer M, Kapur A, et al. Comparison of RTP dose distributions in heterogeneous phantoms with the BEAM Monte Carlo simulation system. J Appl Clin Med Phys. 2001;2:21–31
  36. Miften M, Wiesmeyer M, Monthofer S, et al. Implementation of FFT convolution and multigrid superposition models in the FOCUS RTP system. Phys Med Biol. 2000;45:817–833
  37. Mackie TR, Bielajew AF, Rogers DW, et al. Generation of photon energy deposition kernels using the EGS Monte Carlo code. Phys Med Biol. 1988;33:1–20
  38. Timmerman RD, Michalski J, Fowler J, et al. A phase II trial of stereotactic body radiation therapy (SBRT) in the treatment of patients with medically inoperable stage I/II non-small cell lung cancer, Protocol 0236. Philadelphia: RTOG; 2006;Available from, http://www.rtog.org/members/protocols/0236/0236.pdfAccessed December 30, 2008
  39. ITC/ATC. Available from: http://atc.wustl.edu/. Accessed February 12, 2009.

 Supported by National Cancer Institute Grants U24 CA 81647, U10 CA21661, and U10 CA32115.

 Presented in part as an oral presentation at the American Society for Therapeutic Radiology and Oncology Annual Meeting, 2007.

 Conflict of interest: none.

PII: S0360-3016(08)03800-5

doi: 10.1016/j.ijrobp.2008.11.019

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1235-1242 , 15 March 2009

Article Tools

* Image Usage & Resolution