International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 3 , Pages 672-676 , 1 November 2009

Testosterone Production is Better Preserved After 16 than 20 Gray Irradiation Treatment Against Testicular Carcinoma In Situ Cells

  • Anne K. Bang

      Affiliations

    • University Department of Growth and Reproduction, Rigshospitalet, DK-2100 Copenhagen, Denmark
    • ,
  • Jørgen H. Petersen, Sc., Ph.D.

      Affiliations

    • University Department of Growth and Reproduction, Rigshospitalet, DK-2100 Copenhagen, Denmark
    • Department of Biostatistics, University of Copenhagen, DK-2200 Copenhagen, Denmark
    • ,
  • Peter M. Petersen, M.D., Ph.D.

      Affiliations

    • University Department of Oncology, Rigshospitalet, DK-2100 Copenhagen, Denmark
    • ,
  • Anna-Maria Andersson, M.Sci., Ph.D.

      Affiliations

    • University Department of Growth and Reproduction, Rigshospitalet, DK-2100 Copenhagen, Denmark
    • ,
  • Gedske Daugaard, M.D., Dr.M.Sci.

      Affiliations

    • University Department of Oncology, Rigshospitalet, DK-2100 Copenhagen, Denmark
    • ,
  • Niels Jørgensen, M.D., Ph.D.

      Affiliations

    • University Department of Growth and Reproduction, Rigshospitalet, DK-2100 Copenhagen, Denmark
    • Corresponding Author InformationAddress reprint requests to: Niels Jørgensen M.D., Ph.D., University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, section 5064, DK-2100 Copenhagen, Denmark. Tel: (+45) 35 45 50 85; Fax: (+45) 35 45 60 54

Received 31 August 2008 ,Revised 12 November 2008 ,Accepted 24 November 2008.

References 

  1. Petersen PM, Giwercman A, Daugaard G, et al. Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-in-situ in the testis. J Clin Oncol. 2002;20:1537–1543
  2. Petersen PM, Giwercman A, Hansen SW, et al. Impaired testicular function in patients with carcinoma-in-situ of the testis. J Clin Oncol. 1999;17:173–179
  3. Giwercman A, von der Maase H, Berthelsen JG, et al. Localized irradiation of testes with carcinoma in situ: Effects on Leydig cell function and eradication of malignant germ cells in 20 patients. J Clin Endocrinol Metab. 1991;73:596–603
  4. Schubert CM, Rogers NL, Remsberg KE, et al. Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: The Fels Longitudinal Study. Int J Obesity. 2006;30:251–260
  5. Andersson AM, Jensen TK, Juul A, et al. Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys. J Clin Endorinol Metab. 2007;92:4696–4705
  6. Rossmanith WG, Scherbaum WA, Lauritzen C. Gonadotropin secretion during aging in postmenopausal women. Neuroendocrinol. 1991;54:211–218
  7. Genazzani AD, Petraglai F, Sgarbi L, et al. Difference of LH and FSH secretory characteristics and degree of concordance between postmenopausal and aging woman. Maturitas. 1997;26:133–138
  8. Hansen SW, Berthelsen JG, von der Maase H. Long-term fertility and Leydig cell function in patients treated for germ cell cancer with cisplatin, vinblastin, and bleomycin versus surveillance. J Clin Oncol. 1990;8:1695–1698
  9. Brennemann W, Stoffel-Wagner B, Helmers A, et al. Gonadal function of patients treated with cisplatin based chemotherapy for germ cell cancer. J Urol. 1997;158:844–850
  10. Skakkebæk NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001;16:972–978
  11. Hoei-Hansen C, Holm M, Rajpert-De Meyts , et al. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer. J Pathol. 2003;200:370–374
  12. Holm M, Rajpert-De Meyts E, Andersson A-M, et al. Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio. J Pathol. 2003;199:378–386
  13. Dötsch M, Brauers A, Büttner R, et al. Malignant germ cell tumor of the contralateral testis after radiotherapy for testicular intraepithelial neoplasia. J Urol. 2000;164:452–453
  14. Dieckmann K-P, Lauke H, Michl U, et al. Testicular germ cell cancer despite previous local radiotherapy to the testis. European Urol. 2002;41:643–650
  15. Classen J, Dieckmann K, Bamberg M, et al. Radiotherapy with 16 Gy may fail to eradicate testicular intraepithelial neoplasia: Preliminary communication of a dose reduction trial of the German Testicular Cancer Study Group. Brit J Cancer. 2003;88:828–831

 Niels Jørgensen has received economical support from the Danish Agency for Science, Technology and Innovation (Grant No. 271070678).

 Conflict of interest: none.

PII: S0360-3016(08)03829-7

doi: 10.1016/j.ijrobp.2008.11.057

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 3 , Pages 672-676 , 1 November 2009

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