International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 3 , Pages 711-716 , 1 November 2009

Early Hyperbaric Oxygen Therapy for Reducing Radiotherapy Side Effects: Early Results of a Randomized Trial in Oropharyngeal and Nasopharyngeal Cancer

  • David N. Teguh, M.D.

      Affiliations

    • Department of Radiation Oncology, Rotterdam, The Netherlands
    • ,
  • Peter C. Levendag, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Rotterdam, The Netherlands
    • Corresponding Author InformationReprint requests to: Peter C. Levendag, M.D., Ph.D., Erasmus Medical Center—Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands. Tel: (+31) 10-7041366; Fax: (+31) 10-7041013
    • ,
  • Inge Noever, R.T.T.

      Affiliations

    • Department of Radiation Oncology, Rotterdam, The Netherlands
    • ,
  • Peter Voet, R.T.T.

      Affiliations

    • Department of Radiation Oncology, Rotterdam, The Netherlands
    • ,
  • Henrie van der Est, R.T.T.

      Affiliations

    • Department of Radiation Oncology, Rotterdam, The Netherlands
    • ,
  • Peter van Rooij, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Rotterdam, The Netherlands
    • ,
  • Antoine G. Dumans, M.D., D.D.S.

      Affiliations

    • Department of Maxillofacial Surgery, Rotterdam, The Netherlands
    • ,
  • Maarten F. de Boer, M.D., Ph.D.

      Affiliations

    • Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, The Netherlands
    • ,
  • Michiel P.C. van der Huls, M.D.

      Affiliations

    • Institute for Hyperbaric Medicine, Rotterdam, The Netherlands
    • ,
  • Wouter Sterk, M.D., Ph.D.

      Affiliations

    • Institute for Hyperbaric Medicine, Rotterdam, The Netherlands
    • ,
  • Paul I.M. Schmitz, Ph.D.

      Affiliations

    • Department of Biostatistics of Erasmus Medical Center—Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Received 24 July 2008 ,Revised 24 November 2008 ,Accepted 27 November 2008.

References 

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  2. Eisbruch A, Ship JA, Dawson LA, et al. Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer. World J Surg. 2003;27:832–837
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  6. Teguh DN, Levendag PC, Voet P, et al. Trismus in patients with oropharyngeal cancer: Relationship with dose in structures of mastication apparatus. Head Neck. 2008;30:622–630
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  14. van Merkesteyn R, Bakker DJ. Comment on “Hyperbaric oxygen therapy for radionecrosis of the jaw: A randomized, placebo-controlled, double-blind trial from the ORN96 Study Group.”. J Clin Oncol. 2005;23:4465–4466
  15. Bradfield JJ, Kinsella JB, Mader JT, Bridges EW. Rapid progression of head and neck squamous carcinoma after hyperbaric oxygenation. Otolaryngol Head Neck Surg. 1996;114:793–797
  16. Feldmeier J, Carl U, Hartmann K, Sminia P. Hyperbaric oxygen: Does it promote growth or recurrence of malignancy?. Undersea Hyperb Med. 2003;30:1–18
  17. Schonmeyr BH, Wong AK, Reid VJ, et al. The effect of hyperbaric oxygen treatment on squamous cell cancer growth and tumor hypoxia. Ann Plast Surg. 2008;60:81–88
  18. Marx RE, Johnson RP, Kline SN. Prevention of osteoradionecrosis: A randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assoc. 1985;111:49–54
  19. Gerlach NL, Barkhuysen R, Kaanders JH, et al. The effect of hyperbaric oxygen therapy on quality of life in oral and oropharyngeal cancer patients treated with radiotherapy. Int J Oral Maxillofac Surg. 2008;37:255–259
  20. Clarke RE, Tenorio LM, Hussey JR, et al. Hyperbaric oxygen treatment of chronic refractory radiation proctitis: A randomized and controlled double-blind crossover trial with long-term follow-up. Int J Radiat Oncol Biol Phys. 2008;72:134–143

 Conflict of interest: none.

PII: S0360-3016(08)03830-3

doi: 10.1016/j.ijrobp.2008.11.056

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 3 , Pages 711-716 , 1 November 2009

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