International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1260-1269 , 15 March 2009

A Comprehensive Assessment by Tumor Site of Patient Setup Using Daily MVCT Imaging From More Than 3,800 Helical Tomotherapy Treatments

  • Leah K. Schubert, M.S.

      Affiliations

    • Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI
    • Corresponding Author InformationReprint requests to: Leah K. Schubert, M.S., University of Wisconsin School of Medicine and Public Health, Department of Medical Physics, Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Room 1005, Madison, WI 53705. Tel: (608) 262-2170; Fax: (608) 262-2413
  • ,
  • David C. Westerly, M.S.

      Affiliations

    • Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • ,
  • Wolfgang A. Tomé, Ph.D.

      Affiliations

    • Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI
    • Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • ,
  • Minesh P. Mehta, M.D.

      Affiliations

    • Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • ,
  • Emilie T. Soisson, M.S.

      Affiliations

    • Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • ,
  • Thomas R. Mackie, Ph.D.

      Affiliations

    • Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI
    • Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • ,
  • Mark A. Ritter, M.D., Ph.D.

      Affiliations

    • Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI
    • Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • ,
  • Deepak Khuntia, M.D.

      Affiliations

    • Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • ,
  • Paul M. Harari, M.D.

      Affiliations

    • Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • ,
  • Bhudatt R. Paliwal, Ph.D.

      Affiliations

    • Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI
    • Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI

Received 3 July 2008 ,Revised 6 November 2008 ,Accepted 13 November 2008.

References 

  1. Dawson LA, Jaffray DA. Advances in image-guided radiation therapy. J Clin Oncol. 2007;25:938–946
  2. Mackie TR, Kapatoes J, Ruchala K, et al. Image guidance for precise conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2003;56:89–105
  3. Mackie TR, Balog J, Ruchala K, et al. Tomotherapy. Semin Radiat Oncol. 1999;9:108–117
  4. Welsh JS, Lock M, Harari PM, et al. Clinical implementation of adaptive helical tomotherapy: A unique approach to image-guided intensity modulated radiotherapy. Tech Cancer Res Treat. 2006;5:465–479
  5. Forrest LJ, Mackie TR, Ruchala K, et al. The utility of megavoltage computed tomography images from a helical tomotherapy system for setup verification purposes. Int J Radiat Oncol Biol Phys. 2004;60:1639–1644
  6. Welsh JS, Bradley K, Ruchala KJ, et al. Megavoltage computed tomography imaging: A potential tool to guide and improve the delivery of thoracic radiation therapy. Clin Lung Cancer. 2004;5:303–306
  7. Ling CC, Yorke E, Fuks Z. From IMRT to IGRT: Frontierland or neverland?. Radiother Oncol. 2006;78:119–122
  8. Amols HI, Jaffray DA, Orton CG. Image-guided radiotherapy is being overvalued as a clinical tool in radiation oncology. Med Phys. 2006;33:3583–3586
  9. Mackie TR. History of tomotherapy. Phys Med Biol. 2006;51:R427–R453
  10. Boswell S, Tomé W, Jeraj R, et al. Automatic registration of megavoltage to kilovoltage CT images in helical tomotherapy: An evaluation of the setup verification process for the special case of a rigid head phantom. Med Phys. 2006;33:4395–4404
  11. Meeks SL, Harmon JF, Langen KM, et al. Performance characterization of megavoltage computed tomography imaging on a helical tomotherapy unit. Med Phys. 2005;32:2673–2681
  12. Yan D, Wong J, Vicini F, et al. Adaptive modification of treatment planning to minimize the deleterious effects of treatment setup errors. Int J Radiat Oncol Biol Phys. 1997;38:197–206
  13. Yan D, Lockman D, Martinez A, et al. Computed tomography guided management of interfractional patient variation. Semin Radiat Oncol. 2005;15:168–179
  14. van Herk M. Errors and margins in radiotherapy. Semin Radiat Oncol. 2004;14:52–64
  15. Langen KM, Jones DT. Organ motion and its management. Int J Radiat Oncol Biol Phys. 2001;50:265–278
  16. Booth JT, Zavgorodni SF. Set-up error and organ motion uncertainty: A review. Australas Phys Eng Sci Med. 1999;22:29–47
  17. Smeenk C, Gaede S, Battista JJ. Delineation of moving targets with slow MVCT scans: Implications for adaptive non-gated lung tomotherapy. Phys Med Biol. 2007;52:1119–1134
  18. Hong TS, Tomé WA, Chappell RJ, et al. The impact of daily setup variations on head-and-neck intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2005;61:779–788
  19. Orton NP, Tomé WA. The impact of daily shifts on prostate IMRT dose distributions. Med Phys. 2004;31:2845–2848
  20. Guckenberger M, Meyer J, Vordermark D, et al. Magnitude and clinical relevance of translational and rotational patient setup errors: A cone-beam CT study. Int J Radiat Oncol Biol Phys. 2006;65:934–942

 This work was funded by National Institutes of Health National Cancer Institute Grant PO1 CA088960.

 Conflict of interest: The authors T. R. Mackie and E. T. Soisson have financial interests in TomoTherapy, Inc., and therefore may have a potential conflict of interest. No other authors report potential conflicts of interest.

PII: S0360-3016(08)03832-7

doi: 10.1016/j.ijrobp.2008.11.054

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4 , Pages 1260-1269 , 15 March 2009