« Previous
Next »
International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4
, Pages 1211-1218
, 15 March 2009
Diversity and Complexity of Ceramide Generation After Exposure of Jurkat Leukemia Cells to Irradiation
References
- . Ceramide mediates radiation-induced death of endothelium. Crit Care Med. 2000;28:87–93
- Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med. 1994;180:525–535
- Ceramide induces activation of the mitochondrial/caspases pathway in Jurkat and SCC61 cells sensitive to gamma-radiation but activation of this sequence is defective in radioresistant SQ20B cells. Int J Radiat Biol. 2002;78:821–835
- . Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosis. Oncogene. 2003;22:8645–8652
- . Sphingomyelin hydrolysis during apoptosis. Biochim Biophys Acta. 2002;1585:126–134
- . Acid and neutral sphingomyelinases: Roles and mechanisms of regulation. Biochem Cell Biol. 2004;82:27–44
- . Radiation-induced signal transduction and stress response. Radiat Res. 1998;150:102–108
- Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. J Biol Chem. 1999;274:17908–17917
- p53-dependent ceramide response to genotoxic stress. J Clin Invest. 1998;102:329–339
- Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell. 1996;86:189–199
- Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. 1997;57:4340–4347
- Activation of a nuclear sphingomyelinase in radiation-induced apoptosis. FASEB J. 2001;15:123–133
- Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing. Int J Cancer. 2002;101:589–598
- p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis. Cell Death Differ. 2004;11:853–861
- Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 1998;281:1677–1679
- Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction. Lipids. 1998;33:601–605
- Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem. 2000;275:21508–21513
- Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?. Biochem J. 2004;382:527–533
- . Mitochondrial ceramide and the induction of apoptosis. J Bioenerg Biomembr. 2005;37:143–153
- Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J Biol Chem. 1997;272:11369–11377
- Mitochondrial lipid alterations during Fas- and radiation-induced apoptosis. Biochem Biophys Res Commun. 2001;287:1112–1120
- Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin. Oncogene. 2004;23:3650–3658
- Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 2001;15:2669–2679
- Temporal relationships between ceramide production, caspase activation and mitochondrial dysfunction in cell lines with varying sensitivity to anti-Fas-induced apoptosis. Biochem J. 2001;357:407–416
- Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders. Biochim Biophys Acta. 1994;1226:138–144
- Targeting of exogenous ceramides to mitochondria and other subcellular compartments of HL 60 cells. Biochim Biophys Acta. 2002;1583:305–310
- Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering. Free Radic Biol Med. 2007;43:681–694
- . A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911–917
- Growth hormone activity in mitochondria depends on GH receptor Box1 and involves caveolar pathway targeting. Exp Cell Res. 2006;312:215–232
- . Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003;278:13775–13783
- Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem. 2005;280:26425–26434
- UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal. J Biol Chem. 2005;280:19196–19204
- . Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts. J Biol Chem. 2004;279:36778–36787
- Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains. Blood. 2004;104:1166–1173
- . Ceramide in apoptosis: An overview and current perspectives. Biochim Biophys Acta. 2002;1585:114–125
- Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels. Oncogene. 2004;23:2703–2715
- Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase. Cancer Res. 1999;59:5194–5201
- Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis. J Invest Dermatol. 2005;125:545–553
- . Mitochondrial control of apoptosis: An introduction. Biochem Biophys Res Commun. 2003;304:433–435
- . Mitochondrial regulation of apoptotic cell death. Chem Biol Interact. 2006;163:4–14
- Screening for nitric oxide-dependent protein-protein interactions. Science. 2003;301:657–661
- Ceramide-rich membrane rafts mediate CD40 clustering. J Immunol. 2002;168:298–307
- Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene. 2003;22:5457–5470
- Irradiation of mitochondria initiates apoptosis in a cell free system. Oncogene. 2001;20:167–177
- . Ceramide-enriched membrane domains. Biochim Biophys Acta. 2005;1746:284–294
This work was supported by the French ETOILE project of Hadrontherapy and The Ligue Contre le Cancer (Section de l'Ain).
Conflict of interest: none.
PII: S0360-3016(08)03867-4
doi: 10.1016/j.ijrobp.2008.11.033
© 2009 Elsevier Inc. All rights reserved.
« Previous
Next »
International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 4
, Pages 1211-1218
, 15 March 2009
