International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1291-1292 , 1 April 2009

Elective Nodal Irradiation for Locally Advanced Non–Small-Cell Lung Cancer: It's Called Cancer for a Reason

  • Chris R. Kelsey, M.D.

      Affiliations

    • Department of Radiation Oncology, Duke University Medical Center, Durham, NC
    • Corresponding Author InformationReprint requests to: Chris R. Kelsey, M.D., Duke University Medical Center, Durham, NC 27710. Tel: (919) 668-5213; Fax: (919) 668-7345
    • ,
  • Lawrence B. Marks, M.D.

      Affiliations

    • Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC
    • ,
  • Eli Glatstein, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA

Received 18 November 2008 ,Accepted 10 December 2008.

References 

  1. Schild SE. Elective nodal irradiation (ENI) doesn't appear to provide a clear benefit for patients with unresectable non-small-cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 2008;72:311–312
  2. Rosenzweig KE, Sura S, Jackson A, et al. Involved-field radiation therapy for inoperable non small-cell lung cancer. J Clin Oncol. 2007;25:5557–5561
  3. Senan S, Burgers S, Samson MJ, et al. Can elective nodal irradiation be omitted in stage III non-small-cell lung cancer? Analysis of recurrences in a phase II study of induction chemotherapy and involved-field radiotherapy. Int J Radiat Oncol Biol Phys. 2002;54:999–1006
  4. Al-Sarraf N, Aziz R, Gately K, et al. Pattern and predictors of occult mediastinal lymph node involvement in non-small cell lung cancer patients with negative mediastinal uptake on positron emission tomography. Eur J Cardiothorac Surg. 2008;33:104–109
  5. Kim BT, Lee KS, Shim SS, et al. Stage T1 non-small cell lung cancer: Preoperative mediastinal nodal staging with integrated FDG PET/CT—a prospective study. Radiology. 2006;241:501–509
  6. Videtic GM, Rice TW, Murthy S, et al. Utility of positron emission tomography compared with mediastinoscopy for delineating involved lymph nodes in stage III lung cancer: Insights for radiotherapy planning from a surgical cohort. Int J Radiat Oncol Biol Phys. 2008;72:702–706
  7. Lauer MS, Murthy SC, Blackstone EH, et al. [18F]Fluorodeoxyglucose uptake by positron emission tomography for diagnosis of suspected lung cancer: Impact of verification bias. Arch Intern Med. 2007;167:161–165
  8. Yuan S, Sun X, Li M, et al. A randomized study of involved-field irradiation versus elective nodal irradiation in combination with concurrent chemotherapy for inoperable stage III nonsmall cell lung cancer. Am J Clin Oncol. 2007;30:239–244
  9. Hata E, Hayakawa K, Miyamoto H, et al. Rationale for extended lymphadenectomy for lung cancer. Theoretical Surgery. 1990;5:19–25
  10. Nohl-Oser HC. An investigation of the anatomy of the lymphatic drainage of the lungs as shown by the lymphatic spread of bronchial carcinoma. Ann R Coll Surg Engl. 1972;51:157–176
  11. Kelsey CR, Light KL, Marks LB. Patterns of failure after resection of non-small-cell lung cancer: Implications for postoperative radiation therapy volumes. Int J Radiat Oncol Biol Phys. 2006;65:1097–1105

 Conflict of interest: none.

PII: S0360-3016(08)03913-8

doi: 10.1016/j.ijrobp.2008.12.017

International Journal of Radiation Oncology * Biology * Physics
Volume 73, Issue 5 , Pages 1291-1292 , 1 April 2009

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