International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 5 , Pages 1501-1505 , 1 August 2009

Radioprotective Effect of Moderate Wine Consumption in Patients With Breast Carcinoma

  • Alessio G. Morganti, M.D.

      Affiliations

    • Radiotherapy Unit, Department of Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
  • ,
  • Cinzia Digesù, M.D.

      Affiliations

    • Radiotherapy Unit, Department of Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
  • ,
  • Simona Panunzi, M.S.

      Affiliations

    • National Research Council, Institute of Systems Analysis and Computer Science, BioMatLab, Rome, Italy
  • ,
  • Andrea De Gaetano, M.D.

      Affiliations

    • National Research Council, Institute of Systems Analysis and Computer Science, BioMatLab, Rome, Italy
  • ,
  • Gabriella Macchia, M.D.

      Affiliations

    • Radiotherapy Unit, Department of Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    • Corresponding Author InformationReprint requests to: Gabriella Macchia, M.D., Radiotherapy Unit, Department of Oncology, Catholic University, Largo A. Gemelli 1, 86100 Campobasso, Italy. Tel: (+39) 0874-312-259; Fax: (+39) 0874-312-720
  • ,
  • Francesco Deodato, M.D.

      Affiliations

    • Radiotherapy Unit, Department of Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
  • ,
  • M. Grazia Cece, R.T.

      Affiliations

    • Radiotherapy Unit, Department of Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    • Present address: Department of Radiology, General Hospital “SS. Annunziata,” Cento, Italy
  • ,
  • Massimo Cirocco, R.T.

      Affiliations

    • Radiotherapy Unit, Department of Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    • Present address: Department of Nuclear Medicine, General Hospital, Grosseto, Italy
  • ,
  • Augusto Di Castelnuovo, M.S.

      Affiliations

    • Research Laboratories, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
  • ,
  • Licia Iacoviello, Ph.D.

      Affiliations

    • Research Laboratories, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
  • ,
  • Vincenzo Valentini, M.D.

      Affiliations

    • Department of Radiotherapy, Policlinico Universitario “Agostino Gemelli,” Catholic University, Rome, Italy
  • ,
  • Numa Cellini, M.D.

      Affiliations

    • Department of Radiotherapy, Policlinico Universitario “Agostino Gemelli,” Catholic University, Rome, Italy
  • ,
  • Giovanni de Gaetano, Ph.D.

      Affiliations

    • Research Laboratories, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy

Received 22 July 2008 ,Revised 5 September 2008 ,Accepted 1 October 2008.

References 

  1. Antonadou D, Throuvalas N, Petridis A, et al. Effect of amifostine on toxicities associated with radiochemotherapy in patients with locally advanced non–small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2003;57:402–408
  2. Athanassiou H, Antonadou D, Coliarakis N, et al. Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: Results of a randomized trial. Int J Radiat Oncol Biol Phys. 2003;56:1154–1160
  3. Law A, Kennedy T, Pellitteri P, et al. Efficacy and safety of subcutaneous amifostine in minimizing radiation-induced toxicities in patients receiving combined-modality treatment for squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2007;69:1361–1368
  4. Anné PR, Machtay M, Rosenthal DI, et al. A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2007;67:445–452
  5. Andreassen CN, Grau C, Lindegaard JC. Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy. Semin Radiat Oncol. 2003;13:62–72
  6. Weiss JF, Landauer MR. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology. 2003;189:1–20
  7. VijayalaxmiReiter RJ, Tan DX, et al. Melatonin as a radioprotective agent: A review. Int J Radiat Oncol Biol Phys. 2004;59:639–653
  8. Harapanhalli RS, Yaghmai V, Giuliani D, et al. Antioxidant effects of vitamin C in mice following X-irradiation. Res Commun Mol Pathol Pharmacol. 1996;94:271–287
  9. Kumar KS, Srinivasan V, Toles R, et al. Nutritional approaches to radioprotection: Vitamin E. Mil Med. 2002;167:57–59
  10. Redlich CA, Rockwell S, Chung JS, et al. Vitamin A inhibits radiation-induced pneumonitis in rats. J Nutr. 1998;128:1661–1664
  11. Shimoi K, Masuda S, Shen B, et al. Radioprotective effects of antioxidative plant flavonoids in mice. Mutat Res. 1996;350:153–161
  12. Storm HM, Oh SY, Kimler BF, Norton S. Radioprotection of mice by dietary squalene. Lipids. 1993;28:555–559
  13. Sorenson JR. Cu, Fe, Mn, and Zn chelates offer a medicinal chemistry approach to overcoming radiation injury. Curr Med Chem. 2002;9:639–662
  14. Karbownik M, Reiter RJ. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc Soc Exp Biol Med. 2000;225:9–22
  15. Nishimura Y, Kim HS, Ikota N, et al. Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice. J Radiat Res (Tokyo). 2003;44:53–58
  16. Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002;18:872–879
  17. Turner ND, Braby LA, Ford J, Lupton JR. Opportunities for nutritional amelioration of radiation-induced cellular damage. Nutrition. 2002;18:904–912
  18. Bounous G, Le Bel E, Shuster J, et al. Dietary protection during radiation therapy. Strahlentherapie. 1975;149:476–483
  19. Baumann M, Bentzen SM. Clinical manifestations of normaltissue damage. In:  Steel GG editors. Basic clinical radiobiology,. London: Arnold; 2002;p. 105–119
  20. Gali-Muhtasib HU, Yamout SZ, Sidani MM. Tannins protect against skin tumor promotion induced by ultraviolet-B radiation in hairless mice. Nutr Cancer. 2000;37:73–77
  21. Greenrod W, Stockley CS, Burcham P, et al. Moderate acute intake of de-alcoholized red wine, but not alcohol, is protective against radiation-induced DNA damage ex vivo—Results of a comparative in vivo intervention study in younger men. Mutat Res. 2005;591:290–301
  22. Perez CA, Brady LW. Overview. In:  Perez CA,  Brady LW editor. Principles and practices of radiation oncology. 2nd ed. Philadelphia: Lippincott; 1992;p. 1–63
  23. Di Castelnuovo A, Costanzo S, Bagnardi V, et al. Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Arch Intern Med. 2006;166:2437–2445
  24. Nordmann R. Alcohol and antioxidant systems. Alcohol Alcohol. 1994;29:513–522

 Conflict of interest: none.

PII: S0360-3016(09)00090-X

doi: 10.1016/j.ijrobp.2008.10.089

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 5 , Pages 1501-1505 , 1 August 2009